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감초추출액이 멜라닌세포의 증식과 멜라닌화에 미치는 영향
임덕우,이진우,이무형 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-
Background: Licorice has been widely used for its anti-inflammatory action. Recently many studies have revealed that licorice has an inhibitory effect on melanin formation by inhibiting tyrosinase, TRP-1(Tyrosinase-related protein 1) and TRP-2(Dopachrome tautomerase) activity. Most studies have reported that licorice extract inhibits melanogenesis in malignant melanoma cell but there are few reports of the effect of licorice on proliferation and melanization in normal human melanocytes. Furthermore, anti-melanogenetic effect of licorice is different according to the cultivated places. Objective: This study was done to investigate the effects of crude extract(CLE) and oil-soluble extract(OLE) of licorice which is cultivated in China and circulates in Korea on the proliferation and melanization of normal cultured human melanocytes. Methods: CLE(100, 500, 1000㎍/mL) and OLE(1, 10, 100㎍/mL) were added into culture medium respectively. Three days after adding CLE, melanocytes were counted by using hemocytometer, and melanocyte proliferation was measured by MTT and SRB assay. And melanin contents were examined by using spectrophotometer. Melanocytes were counted and melanin contents were measured 2 days and 7 days after adding OLE. Results: In CLE-added groups, the number of melanocytes was significantly lower in experimental groups (500㎍/mL and 1000 ㎍/mL) than in control group(p<0.05). On MTT assay, the proliferation of melanocytes was inhibited significantly in experimental groups(500㎍/mL and 1000㎍/mL) (p<0.05). On SRB assay, the proliferation of melanocytes was inhibited significantly in all experimental groups(p<0.05). This anti-proliferative effect was supposed to be related with the cytotoxic effect of CLE. Melanin contents increased significantly in CLE-added experimental group(500㎍/mL and 1000㎍/mL) than control group(p<0.05). It is considered that the increased melanin contents were caused by strong anti-proliferative effect. Two days after adding OLE, the number of melanocytes had no change in 1㎍/mL-added group, which decreased significantly in 10㎍/mL-added group, All cells were detached from the bottom of culture plate in 100 ㎍/ml-added group. The number had no change in 1㎍/mL-added group, while all cells were detached in 10㎍/mL and 100㎍/mL-added groups 7 days after adding OLE. This means that the concentrations of 10㎍/mL and 100㎍/mL of OLE have cytotoxic effect on melanocyte. Melanin contents decreased significantly on the 2nd day(p<0.05), and decreased slightly on the 7th day in 1㎍/mL OLE-added group. Conclusion: Oil-soluble extract of licorice which is cultivated in China and circulates in Korea has anti-melanogenic effect. Therefore, this material can be used to treat hyperpigmented disorders including melasma.
임덕우(Tuk Woo Lim),박정훈(Jung Hun Park),김현진(Hyun Jin Kim),이무형(Mu Hyoung Lee) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.7
N/A Background : Syringoma is a relatively common benign appendageal tumor derived from the intraepidermal eccrine ducts. It occurs predominantly in women at puberty or later in life. The lesions usually are multiple and may be present in great numbers. Histopathologically, numerous small ducts are embedded in a fibrous stroma and their walls are lined by two rows of epithelial cells. Objective : The aim of this study is to investigate clinical and histopathologic features of syringoma in Koreans. Methods : Total 32 patients were included in this study. Data complied were sex, age, onset of disease, symptoms, family history, localization, distribution, and some histopathologic findings including acanthosis, basal hyperpigmentation, proliferation of fibrous stroma, vacuolization of cells, keratin-filled cyst, and characteristic tad-pole appearance. Results 1. It was observed predominantly in females as the sex ratio of 31:1. The mean age at diagnosis was 37.5-years-old. 2. The age of onset was in the 2nd decade in 9 patients, 3rd decade in 10 patients, 4th decade in 7 patients, 5th decade in 5 patients, and 7th decade in 1 patient. 3. Only two patients complained of mild itching. 4. Family history was noted in 14 patients. 5. It occurred most frequently in the upper and lower eyelids(28 cases), and followed by forehead(5 cases), genitalia(3 cases), temple(2 cases), cheek(1 case), and neck(1 case). 6. The distribution was bilateral except two patients. 7. The color of lesion showed skin-colored(23 cases), yellowish(6 cases), and brownish (3 cases). 8. Twelve cases of acanthosis, 11 cases of basal hyperpigmentation, 26 cases of proliferation of fibrous stroma, 13 cases showing vacuolization of inner cell layer of ducts, 8 cases showing keratin-filled cysts and 15 cases showing characteristic tad-pole appearance were observed. Conclusion : According to our study, syringoma predominantly occurs in eyelids of women as bilateral asymptomatic skin-colored papules and histopathologic findings frequently shows keratin-filled cysts.