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난소종양에서 유세포 측정기를 이용한 DNA의 함량과 돌연변이형 p53유전자 산물의 분석
이찬(C Lee),이규완(KW Lee),김인선(HS Kim) 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.11
The incidence of ovarian carcinoma has been reported to increase in Korea. The majority of these cases occured in the over 45-age group. Because symptoms were initially vague, usually resulted in late presentation and diagnosis is often made in more advanced stages. Although progress in the efficacy of therapeutic modality has been achived in the last decade, prognosis is still poor. At the point of therapeutic view, assessment of a variety of prognostic factors is important and assessment of prognostic factors which can be measured objectively and have better reproducibility should preferably used. It is essential to identify prognostic factors of greater reliablity than that are currenty available . A role for flow cytometry as a means of quatitative analysis of cytology is emerging as a tool for diagnosis of cancer, specific histopathological diagnosis, prognosis and treatment . Aneuploidy of tumor DNA is considered to occur through marked enhancement of chromosomal instability. As in the case of with other common human cancers, accumulation of multiple genetic alterations must be present in ovarian cancer, playing important roles in carcinogenesis and tumor progression. Characterized genetic alterations ranged from proto-oncogene amplification tumor chromosomal deletions. Of those deletion of chromosome 17p seems to be one of the most frequency involved pointing to p53 as a potential matational target. Recently mutations of the p53 gene have been detected in many types of human cancer including ovarian cancer. Many evidences have suggested that p53 acts as tumor suppressor gene in wild-type form where as mutant form had tumorigenic activity. This study was designed to analyze DNA content using flow cytometry in fresh ovarian tumors and to evaluate mutant p53 expression by direct fluorescent method in trypsinized, method fixed , fresh cell suspensions and by immunohistochemical staining . In the present study over-expression of p53 were examined from surgical specimens of ovarian cancer in order to clarify the p53 gene abnormality. Clinicopathological parameters and tumor DNA ploidy pattern were examined in relation to p53 gene mutation in order to understand the role of p53 mutation in ovarian carcinogenesis. The obtained results are summaryzed as follows; 1. Expression of mutant from p53 protein was showed in 12 cases of 22 (54.5%) ovarian cancers. 2. There was no correlation between expression of mutant from of p53 protein and clinicopathological factors such as histologic type, tumor grade and FIGO stage. 3. DNA aneuploidy was found in 11cases of 20(50.0%) ovarian cancers(p0.05). In this study , there is no correlation between expression of mutant p53 protein and stage, or histological type or histological grade in ovarian cancer. There was significant relationship between p53 expression and aneuploidy in ovarian cancer. It is suggested that the mutant of the p53 gene is associated with genesis and progresision of ovarian cancer.
접촉 역학적 접근에 의한 점탄성/탄성, 점탄성/점탄성 재료간의 접합 에너지 측정
이찬(C. Lee),엄윤용(Y.Y. Earmme) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4
The nanoimprint lithography technology makes higher density of semiconductor device and larger<br/> capacity of storage media. In this technology the induced damage while detaching polymer pattern from mold<br/> should be minimized. In order to analyze the problem, the basic knowledge of adhesion between the polymer<br/> and the mold is required. In this study a contact experiment of polyisobutylene specimen with spherical steel<br/> tip and polyisobutylene bead tip was conducted using nano indenter. During the contact experiment with<br/> various loading rate under load control the contact behavior of viscoelastic material was measured, i.e., the<br/> load and displacement between the tip and the specimen were measured. The data was analyzed by HBK<br/> model to obtain the stress intensity factor of contact edge and the contact radius as a function of time. Also the<br/> adhesion energies between steel/polyisobutylene and polyisobutylene/polyisobutylene were obtained<br/> employing the analysis of the crack of viscoelastic material by Schapery.
이은혜(EH Lee),이찬(C Lee),이병희(BH Lee),이유미(YM Lee),이정노(JN Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.7
Uterine arteriovenous malformations [AVMs] are rare cause of massive vaginal bleeding. In the past, hysterectomy had been the only method of diagnosis and treatment. With advent of many imaging modalities, noninvasive diagnosis of AVMs is possible and the transcatheter embolization has been accepted as a treatment of choice. We describe a case of uterine AVM presented with intractable vaginal bleeding and successful transcatheter embolization with coils and glue.
한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발
김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.