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첨가제에 따른 염산시부트라민 정제의 특성화 및 방출거동
박종학 ( Jong Hak Park ),구정 ( Jung Ku ),안식일 ( Sik Il Ahn ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이종문 ( John M Rhee ),강길선 ( Gilson Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
In this study, sibutramine HCl, appetite suppressants were prepared into tablet type with additives such as lactose monohydrate, microcrystalline cellulose(MCC), and PVP K-25 to effective oral administration. We used the polyplasdone XL-10 as disintegrant. We compared the in vitro release behavior of sibutramine from the tablets according to additives with commercial drug, Reductil. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter( DSC). FT-IR and DSC results demonstrates that structure of drug was changed and crystallinity of drug was decreased according to additives. The dissolution rate of sibutramine HCl from tablet greatly increased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) in case of adding lactose monohydrate and PVP K-25. This study suggest that various pharmaceutical excipients could improve the sibutramine HCl release behaviors.
염산 트라마돌을 함유하는 PLGA 미립구의 제조 및 방출거동
박종학 ( Jong Hak Park ),엄신 ( Shin Eom ),안식일 ( Sik Il Ahn ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Tramadol HCl(TH)-loaded poly(L-lactide-co-glycolide)(PLGA) microspheres were prepared by O/O solvent evaporation method for sustained release. We investigated the release behavior according to PLGA molecular weight and concentration. TH-loaded PLGA microspheres were characterized on the surface and cross-section morphology by SEM. TH-loaded PLGA microspheres had smooth surfaces and various pores in internal structure. As the PLGA molecular weight and PLGA concentration increased, the release rate of TH decreased. The behaviors of degradation was decreased according to increased PLGA molecular weight. These results showed that the release behaviors can be controlled by various of molecular weight and concentration of PLGA.
수용성 고분자에 따른 실로스타졸 고체분산체의 특성화 및 조절된 방출거동
박종학 ( Jong Hak Park ),김세호 ( Se Ho Kim ),오재민 ( Jae Min Oh ),안식일 ( Sik Il Ahn ),김윤태 ( Yun Tae Kim ),정수현 ( Su Hyun Jung ),최진희 ( Jin Hee Choi ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
The aim of this study was to improve dissolution rate and controlled release of poorly water-soluble drug, cilostazol, using general water soluble polymers. We prepared solid dispersed cilostazol with hydrophilic polymer, Poly-N-Vinylpyrolidone(PVP), Plasdone S630, Hydroxypropylmethylcellulose(HPMC), PEG 6000, Eudragit E100, and surfactant, Poloxamer 407. Characterization of cilostazol solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and infrared spectrometry(FT-IR). SEM and DSC were found that amorphous in solid dispersion. Particle size analyzer was used to investigate size of cilostazol in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2). The release behavior of cilostazol was controlled release with hydrophilic polymers and solid dispersed cilostazol with hydrophilic polymers was sustained release behavior than initial burst release of commercial drug(Pletal(R)). This studies suggest that this solid dispersion system with hydrophilic polymers controlled poorly water-soluble drug, cilostazol, release behaviors.
박종학 ( Jong Hak Park ),김세호 ( Se Ho Kim ),안식일 ( Sik Il Ahn ),최진희 ( Jin Hee Choi ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),이종문 ( John M Rhee ),강길선 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Poorly water-soluble drug, Raloxifene HCl, is a selective estrogen receptor modulator(SERM) and is currently being used for prevention of osteoporosis in postmenopausal women. We prepared solid dispersion with hydrophilic polymer, polyvinylpyrrolidone(PVP), and surfactant, Poloxamer 407, to improve the solubility of drug. Characterization of raloxifene HCl solid dispersion analyzed by scanning electron microscope(SEM) and Fourier transform infrared spectrometry(FT-IR). SEM and FT-IR were found that raloxifene HCl is amorphous and hydrogen bonding between drug and polymer in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8). The dissolution rate of raloxifene HCl was dramatically higher than commercial drug(Evista(R)). This studies suggest that this solid dispersion system improved the bioavailability of poorly water-soluble drug, such as raloxifene HCl.