http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
인간 지방유래 줄기세포가 T-세포중재 면역반응에 미치는 영향
조혜경 ( Hye Kyung Cho ),김혜수 ( Hye Soo Kim ),이일우 ( Il Woo Lee ) 한국조직공학과 재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
Mesenchymal stem cells derived from adult bone marrow or adipose tissue are known to be less immunogenic and besides immunosuppressive. But the detail of immunologic effect of adipose-derived stem cells(ADSCs) is not revealed yet. This study is aimed to investigate the effect of ADSCs on lymphocytes proliferation and the production of cytokines in vitro. The ADSCs extracted from omental or subcutaneous fat were expanded during third to fifth passages. The phenotype of the ADSCs was identified by the conventional cell surface markers using flow cytometry: positive for CD29 and CD44, but negative for CD34, CD45, CD117 and HLA-DR. The ADSCs were able to differentiate into the osteoblast or adipocytes with induction media. Third-party ADSCs added to the mixed lymphocyte reactions(MLR) induced overall suppressive effect on lymphocytes proliferation, but in part stimulated, whereas the suppressive effect of ADSCs on the nonspecific lymphocyte proliferation provoked by phytohemagglutinin-A(PHA-A) was totally profound. The stimulated index(SI = [(responder cell + stimulator cell + ADSC)/responder cell + stimulator cell] × 100) was 11.69% to 156.5% in MLR and 0.99% to 14.44% in PHA-A assay. The changes of cytokines production were analyzed from the supernatant collected during the lymphocyte proliferation reactions using ELISA. The production of TNF- α, IL-2, IFN- γ was increased during the MLR and PHA-A stimulation. Adding ADSCs, only the level of TNF- α was decreased in MLR, whereas all of three cytokines was decreased in PHA-A stimulation. The level of Th1 cytokines such as IL-2 and IFN- γ in MLR was significantly increased during co-culture with ADSCs regardless of suppressive or stimulated response. The changes of Th2 reaction such as IL-4, IL-5, IL-13 were minimal and statistically insignificant. The effects of ADSCs on immunologic or nonspecific lymphocyte stimulation are different in extent and cytokine regulation. Further studies will be needed before the clinical application of ADSCs to regenerative medicine.
이일우,Lee, Il-U 한국방위산업진흥회 1993 國防과 技術 Vol.- No.174
93년 5월호에 1편이 게재된 이후 3개월만에 필자를 달리하여 러시아의 항공 방산업체의 대외전략에 관하여 살펴봅니다 냉전종식과 체제붕괴에 따른 정책 혼란으로, 변환기를 맞고 있는 러시아의 항공산업을 돌아보고, 우리의 방위산업을 점검해 볼 수 있는 좋은 기회가 되리라 생각합니다 계속해서 93년 9월호에 3편(총 3편)이 게재됩니다
이일우,Lee, Il-U 한국방위산업진흥회 1993 國防과 技術 Vol.- No.175
러시아의 항공산업 역사는 복잡다양할 뿐만아니라, 국방산업과 연관되어 비밀리에 발전되어 상세히 알려지지 않았으나, 페레스트로이카 정책 추진 이후 서방의 주요 에어쇼 참가등을 통해 많이 공개되었습니다 현재 러시아의 정치, 사회적 변화가 극심한 관계로 항공산업조직의 정확한 추정은 곤란하지만, 이 글에서는 최근 2-3년간 주요기관들의 변화, 동향을 살펴봄으로써 자본주의 결제체제로의 전환전략 및 가능성을 살펴봅니다