전자제품의 해외 시장 개척과 확대

이은직,Lee, Eun-Jik 한국전자정보통신산업진흥회 1984 電子振興 Vol.4 No.8

뇌하수체 Prolactin 분비 미세 선종의 추적 관찰

이은직(Eun Jig Lee),김경래(Kyung Rae Kim),안광진(Kwang Jin Ahn),정윤석(Yoon Sok Chung),정재희(Jae Hee Jung),김미림(Mi Rim Kim),임승길(Sung Kil Lim),이현철(Hyun Chul Lee),정태섭(Tae Seop Jung),김동익(Dong Ik Kim),이병석(Byung Seok Lee 대한내과학회 1992 대한내과학회지 Vol.43 No.5

N/A N/A

뇌하수체 성선자극호르몬 분비세포 선종

이은직(Eun Jig Lee),이현철(Hyun Chul Lee),안광진(Kwang Jin Ahn),임세중(Se Joong Rim),정윤석(Yoon Sok Jung),이관우(Kwan Woo Lee),임승길(Sung Kil Lim),김경래(Kyung Rae Kim),허갑범(Kap Bum Huh),양우익(Woo Ik Yang),박찬일(Chan Il Park),최 대한내과학회 1991 대한내과학회지 Vol.41 No.6

N/A This retrospective study concerns 73 patients with nonfunctioning pituitary adenoma who were operated on during an 9-year period from 1981 to 1989. Among them, 7 men showed positive immunocytochemistry for FSH and negative for other pituitary hormones. Six of them had elevated serum FSH levels, and LH levels were normal. Testosterone levels were low in six patients tested. Their major symptoms were visual impairment, headache, and impotence, which had developed from two months to 2 years before sugery. Primary hypogonadism could be eliminated on clinical grounds (recent onset of hypogonadism, previous fertility, and posttreatment-improvement). Transsphenoidal adenomectomies were performed in all patients, and radiation-therapies were paralleled in 6 of them. Clinical recovery occurred in all patients. One patient who did not received radiation therapy showed regrowth of tumor mass after 18 months. In remaining 6 patients, we haven't found any evidence of tumor recurrence during follow-up period from 10 months to 6.3 years. We conclude that these 7 men had primary gonadotrope adenoma of the pituitary, and present them with a literature review.

TSH 분비 뇌하수체 선종 환자들의 임상적, 생화학적 특징과 치료

이우경 ( Woo Kyung Lee ),황세나 ( Se Na Hwang ),임정수 ( Jung Soo Lim ),김현민 ( Hyun Min Kim ),이은영 ( Eun Young Lee ),이상국 ( Sang Kook Lee ),김선호 ( Sun Ho Kim ),이은직 ( Eun Jig Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.1

Background/Aims: Thyrotropin (TSH)-secreting pituitary adenoma (TSHoma) is rare and represents 1~2% of all pituitary adenomas. TSHoma should be distinguished from the thyroid hormone resistance syndrome. Patients with TSHoma may be misdiagnosed with primary hyperthyroidism and often receive inappropriate thyroid gland treatment. Methods: We assessed the clinical characteristics of patients with TSHoma who presented to Severance Hospital at the Yonsei University College of Medicine, Seoul, Korea between 2005 and 2009. Results: Of 484 patients who underwent pituitary tumor resection, eight (1.65%; five women and three men) were found to have TSHoma. The mean age was 40.6±8.9 years at diagnosis (range, 28~55 years). The median duration from onset of symptoms to diagnosis was 17 months (range, 4~60 months). Four patients had overt symptoms of hyperthyroidism and two had visual field defect. Six patients had elevated free thyroxine (FT4) levels with elevated or inappropriately normal TSH levels, and two patients had symptoms associated with Hashimoto`s thyroiditis. The serum levels of free α-subunit measured in two patients were elevated. Six of the tumors were macroadenomas (>10 mm) and two were microadenomas. Complete tumor removal was achieved in all patients. Five patients had preoperative anterior pituitary dysfunction; three patients recovered from this after surgery. Three patients were lost to follow up and five patients showed no evidence of recurrence or hyperthyroidism in the follow-up period (mean, 30.8 months, range, 3~57). Conclusions: Early diagnosis and complete removal of the tumor mass may improve the neurological and endocrine deficits. (Korean J Med 2011;80:47-55)

한국인에서의 비전형적 당뇨병

이은직(Eun J . Lee),김도영(Doe Y . Kim),허갑범(Kap B . Huh),김현만(Hyeon M . Kim),임승길(Sung K . Lim),김경래(Kyung R . Kim),이현철(Hyun C . Lee),김덕회(Duk H . Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.6

N/A Of 501 Korean diabetics admitted to Severance Hospital, Yonsei University College of Medicine, non-obese non-insulin-dependent diabetes mellitus (NIDDM) comprised 319 cases (63.7%), obese NIDDM 100 cases (19.9%) and insulin-dependent diabetes mellitus (IDDM) 82 cases (16.4%). And in the IDDM group thus collected, juvenile-onset diabetes (JOD) comprised 17 cases (3.4%), youth-onset underweight diabetes (YOUD) 25 cases (5.0%) and maturity-onset underweight diabetes (MOUD) 40 eases (8.0%). The caloire intakes just before the onset of diabetes in YOUD and MOUD patients were found to be 63.1% and 60.9% and the intakes of protein 55.9% and 79.8% of the recommended dietary allowance, respectively. Among JOD, YOUD and MOUD, there were no significant differences in body weight, and fasting blood glucose and HbA1c levels at the time of admission. The basal and peak serum C-peptide levels in YOUD (1.03±0.61ng/ml, 1.59±1.23ng/ml) were slightly higher than those in JOD (0.64±0.30ng/ml, 1.05±0.54ng/ml), but significantly lower than those in MOUD (1.61±0.73ng/ml, 2.65±1.30ng/ml). Between JOD and YOUD, there was no significant difference in family histories (23.5%, 24.0%) or clinical features. However, MOUD turned out to have significantly lower family history (2.5%), no history of diabetic ketoacidosis and more pulmonary tuberculosis than the former 2 groups. Of 29 young diabetics (JOD and YOUD) who were followed-up at OPD, 14 cases (5 JOD and 9 YOUD) were ketosis-resistant. These data suggest that, in Korea which is located in temperate zone, malnutrition-related diabetes mellitus (MRDM) can be mainly classified into 2 groups: The youth-onset one had the characteristics of IDDM with the history of undernutrition and ketosis-resistance, and the maturity-onset one may belong to NIDDM with the higher susceptibility to pulmonary tuberculosis.

알레르기 질환에서 피부단자시험과 RAST 성적에 관한 연구

이은직(Eun Jig Lee),김준명(June Myeong Kim),이수곤(Soo Gon Lee),박해심(Hae Sim Park),오승헌(Seung Heon Oh),홍천수(Chein Soo Hong) 대한내과학회 1987 대한내과학회지 Vol.32 No.4

N/A The prick skin test and RAST were used commonly in demonstrating the presence of skin sensitizing antibody in the diagnosis of allergic diseases. The agreement rate and correlation between skin test and RAST were studied by using Phadebas RAST kits and Bencard allergen extracts of 37 common allergens. The following results were obtained; 1) Total agreement rate of 37 allergens between skin test and RAST was 62.3% in 1840 samples. 2) The positive rate of RAST was 20,3% in the + positive group of skin test in all allergens 34.4% in %, and 83.19o in %. 3) Correlation coefficient between skin test and RAST was 0.79 in D. pteronyssinus, 0.67 in D. farinae, and 0.55 in house dust. 4) RAST positive rate of positive skin test and RAST negatvie rate of negative skin test were 68.7%, 94.4% in D. pteronyssinus, 57.8%, 91.3% in D. farinae 47.5%, 96.1 % in Artemisia, 42.4%, 84.3% in Ambrosia, and 32.8%, 97.9% in house dust. 5) RAST positive rate of D. pteronyssinus, D. Farinae, house dust, cat epithelium, cockroach, Ambrosia, Artemisia, mold were 31.0%, 35.1%, 16.4%, 21.7%, 53.8 %, 10.0%, 13.3%, 47,1% in patients with asthma, 59.6%, 55.8%, 30.0%, 18.2%, 22.2%, 48.0%, 39.4%, 34.1% in allergic rhinitis, 60.2%, 56.9%, 37.4%, 34.1%, 40.0%, 21.2 %, 23.2%, 20.0% in asthma associated with allergic rhinitis, 6) The positive RAST rate of D. pteronyssinus was 88.1% when RAS1 of D. Farinae was positive, and positive RAST rate of D. farinae 88.8% when RAST of D. pteronyssinus positive.

면역세포화학 염색법과 전자 현미경검사를 통한 뇌하수체 선종의 특징

이은직(Eun Jig Lee),이현철(Hyun Chul Lee),양우익(Woo Ik Yang),김경래(Kyung Rai Kim),김현만(Hyun Man Kim),안광진(Kwang Jin Ahn),정윤석(Yoon Sok Chung),임승길(Sung Kil Lim),김태승(Tae Seung Kim),박찬일(Chan Il Park),최인준(In Joon choi 대한내과학회 1992 대한내과학회지 Vol.43 No.2

N/A Background: The development of immunocytochemistry and the application of electron microscopy improved the knowledge of the pathology and classification of the pitutiary adenomas. We investigated the characteristics of the pituitary adenomas examined by the immunocytochemistry and electron microscopy. Methods: 44 patients with the pituitary adenomas were investigated, using immunocytochemical techniques in paraffin-embedded tissue, and electron microscopy in fresh tissue. Results: The mean age was 38±13 years, and the ratio of male to female was 1: 2.4 and 18 were prolactinomas, 8 acromegalies, 3 acromegalies with hyperprolactinemia, 3 Cushing`s diaseases, 3 FSH secreting adenomas, 1 TSH secreting adenomas, and 6 nonfunctioning adenomas among 44 patients. The agreement between serum prolactin and prolactin immunocytochemistry was 77.3% if the serum prolaetin level to predict lactotrope adenoma was above 50ng/ml; however, the agreement was 93,2% if the serum prolatin level above 100ng/ml. The serum levels of prolactin and growth hormone in sparsely granulated lactotrope and somatotrope adenomas were 1149.6, 109.5ng/ml, respectively, which were higher than those (129.6, 35.9ng/ml) of densely granulated ones. Immunocytochemical and electron microscopic analysis revealed that thirteen were lactotrope adenomas (12 sparsely granulated, and 1 densely granulated), 9 somatotrope adenomas (6 sparsely granulated and 3 densely granulated), 6 gonadotrope, 4 corticotrope (3 symtomatic and 1 silent), 1 mixed somatotrope and lactotrope, 1 mammosomatotrope, 1 thyrotrope, and 9 null cell (6 nononcocytic, and 3 oncocytic) adenomas. Conclusion: The immunocytochemistry, permitting the visualization of intracellular hormones in the tissue of the pituitary adenoma, made exact histologic diagnosis. So, we have known whether the cause of hyperprolactinemia was lactotrope adenoma or functional hyperprolactinemia due to PIF inhibiton. And it was also possible to diagnose silent corticotrope adenoma and gonadotrope adenoma which had no apparent clinical manifestation. Electron microscopic examination of the pituitary adenoma diagnosed by immunocytchemistry showed ultrastructrural characteristics of the adenoma cells containing each hormones, Accordingly, we could subclassify the pituitary adenoma. However, the identification of the adenomas with somewhat similar ultrastrutural features such as null cell, gonadotrope, and thyrotrope adenoma, may be facilitated by immunocytochemistry. Accordingly, both immunocytochemistry and electron microscopy are necessary for the identification and characterization of the pituitary adenomas.

DME-LPG 혼합연료의 연소효율 측정실험

이현찬(Lee, Hyenchan),백영순(Baek, Youngsoon),최창우(Choi, Changwoo),이은직(Lee, Eunjic) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.06

대표적인 에너지원인 석유는 매장량 및 매장지역이 한정되어 있으며, 환경오염, 연료공급 등의 문제를 안고 있다. 에너지의 대부분을 수입하고 있는 우리나라는 경제성장 및 소득수준 향상으로 에너지 소비량이 증가하면서, 국제유가 상승은 국가 경제에도 큰 악영향을 미치고 있다. 이러한 상황에서 화석연료인 석유를 대체하기 위하여 최근 차세대 대체에너지에 대한 관심이 높아지면서 청정연료인 디메틸에테르(Dimethyl Ether : DME)의 사용방안에 대한 기술개발이 활발히 진행되고 있다. 정부(지식경제부)에서는 DME 보급을 위한 기본계획에서 3단계의 보급계획에 따라 2013년까지 DME를 상용화하겠다는 목표를 발표한바 있다. 그래서 2007년부터 2009년까지 2년간 정부 주관 하에 한국가스공사 등이 1단계 DME 보급을 위한 실증연구를 수행하였다. 1단계 실증연구를 통해 DME-LPG 혼합연료에 대한 품질 및 안전기준을 마련하였으며, DME를 일반 가정 및 상업용으로 시범보급 할 수 있는 특례고시가 2009년 11월에 제정되었다. 현재 제정된 DME-LPG 시범보급 특례고시에 따라 2009년 12월부터 2011년 11월까지 2년간 2단계 시범보급 연구가 진행되고 있다. 2단계 시범보급연구에서는 한국가스공사외 3개 기관이 함께 참여하여 연구를 수행하고 있다. 시범보급에서는 DME-LPG 혼합연료를 일반 가정 및 상업용으로 직접 소비자에게 시범적으로 보급하는 만큼, DME-LPG 혼합연료가 LPG 연료에 비해서 연소효율이 어느 정도 수준인지를 비교하는 것이 매우 중요한 사항이므로 본 실험에서는 가정 및 상업용으로 사용되는 연소기기를 대상으로 LPG 및 DME-LPG 혼합연료에 대해 연소효율을 측정하는 실험을 수행하였다.

당뇨병성 백서에서 Vanadate 투여후 혈당의 변화와 근육세포내 포도당운반체 활성도 및 유전자의 조절

이현철(Hyun Chul Lee),남문석(Moon Suk Nam),이은직(Eun Jig Lee),임승길(Seung Kil Lim),김경래(Kyung Rae Kim),허갑범(Kap Bum Huh),정윤석(Yoon Sok Chung),이관우(Kwan Woo Lee),조용욱(Yong Wook Cho) 대한내과학회 1995 대한내과학회지 Vol.48 No.3

N/A Objectives: Vanadate is known to mimic several effect of insulin including the stimulation of glucose uptake and oxidation, glycogen synthesis as well as the anti-lipolytic effect. But mechanisms for these effects of vanadate are still not completely understood. The aim of this study was to elucidate the effects of vanadate on intrinsic activity of the glucose transporter and the regulation of the glucose transporter mRNA. Methods: Using age and weight-matched male Sprague-Dawley rats (average weight 250 g), the experimental groups were divided into nondiabetic rats (n= 6), streptozotocin (STZ)-induced diabetic rats (n=6), metavanadate and pervanadate treated diabetic rats (n =12). We measured weight, blood glucose, glucose transporter activity, and glucose transporter 4 (GLUT4) mRNA change. Results: 1) STZ-induced diabetic rats became catabolic and they lost their weight, but after 3 to 4 weeks of treatment with metavanadate or pervanadate, body weights were increased. Blood glucose levels in metavanadate or pervanadate treated rats were significantly lower than STZ-induced diabetic rats after 1 week treatment. 2) There was no significant toxicity in vanadates treated rats, compared with STZ-induced diabetic rats and there was no abnormal change in kidney and liver of rats under light microscope 8 weeks after vanadates treatment. 3) The glucose transporter activity of diabetic rats was significantly decreased, compared with that of normal control rats, and increased after vanadates treatment. 4) The glucose transporter mRNA of diabetic rats was markedly decreased, compared with that of normal control rats, and increased after vanadates treatment. Conclusion: In STZ-induced diabetic rats, vanadates treatment may improve insulin sensitivity through in- creased expression of GLUT4 gene.

갑상선질환에서 혈청 Lipoprotein ( a )

조재식(Jae Sik Cho),이은직(Eun Jig Lee),김경래(Kyung Rae Kim),이경미(Kyeong Mi Lee),남문석(Moon Suk Nam),조재화(Jae Hwa Cho),신은택(Eun Tack Shin),임승길(Sung Kil Lim),이현철(Hyun Chul Lee),허갑법(Kap Bum Huh),김정호(Jeong Ho Kim),송경 대한내과학회 1994 대한내과학회지 Vol.47 No.1

N/A Background: Thyroid hormone closely relates with lipid metabolism and especially Hypothyroidism associates with hypercholesterolemia which accelerates atherosclerosis. The purpose of this study was to determine the relationship between thyroid disease and Lp (a). Methods: We evaluated 14 patients with hypothyroidism, 24 patients with hyperthyroidism and 50 normal subjects. Serum Lp (a) was measured by ELISA (IM- MUNOZYM GMBH, Germany), thyroid hormones were measured by ELISA and other lipid profiles by conventional methods. Results: Serum Lp(a) concentrations (median) of hypothyroidism (29.3 mg/dl) were significantly higher than those of hyperthyroidism (4 mg/dl and controls (10 mg/dl)(p<0.05), Total cholesterol and LDL-cholesterol of hypothyroidism (199.0±75.7 mg/dl, 134.6±57.5 mg/dl) were patients had higher total cholesterol (136.1±31.2 mg/dl) and LDL-cholesterol (66.7±31.4 mg/dl) than controls (p<0.05). Serum Lp (a) concentration had negative correlation with the levels of serum T₃, T₄, FT₄ and positive correlation with TSH (p<0.05). Conclusion: These results suggest that thyroid hormones have an influence on Lp (a) concentration.