4령기 Chironomus riparius를 이용한 은나노물질과 NOM 간의 생태독성 연구

이시원(Si-Won Lee),최진희(Jin-Hee Choi) 환경독성보건학회 2013 한국독성학회 심포지움 및 학술발표회 Vol.2013 No.5

대학생의 지연동기, 불안.우울, 자기구실 만들기, 지연행동의 구조적 관계 분석

이시원(Si-won Lee),이지연(Jee-yon Lee) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.12

목적 본 연구에서는 대학생들의 지연동기가 불안⋅우울, 자기구실 만들기를 거처 지연행동에 이르는 경로를 분석하였다. 방법 이를 위해 연구 목적에 대해 설명하고 자발적으로 동의한 대학교 재학 중인 남녀 대학생 362명을 대상으로 2021년 2월 15일부터 2021년 2월 28일까지 지연동기, 불안⋅우울, 자기구실 만들기, 지연행동 관련 변인에 대한 설문자료를 수집 후 구조방정식을 활용해 이들의 관계를 파악하고자 하였다. 결과 이에 대한 연구결과는 다음과 같다. 첫째, 지연동기, 자기구실 만들기, 불안⋅우울, 지연행동은 정적상관을 보인다. 둘째, 지연동기, 불안⋅우울, 자기구실 만들기 간의 관계에서는 불안⋅우울의 부분 매개효과를 확인하였다. 셋째, 지연동기, 불안⋅우울, 지연행동의 관계에서 불안⋅우울의 부분 매개효과를 확인하였다. 결론 본 연구를 토대로 지연동기에 따른 지연행동자의 모습과 지연동기에 따른 자기구실 만들기를 좀 더 깊게 이해하는 것을 돕고, 상담 및 임상 장면의 지연행동 문제에 개입하고 이해하는 데 적용할 수 있는 자료로 활용될 것이다. Objectives The purposes of this study was to examine relationship between motivation of procrastination and procrastination of undergraduates. And would like to examine the mediation effects of self-handicapping, anxiety and depression. Methods The data were collected from 362 undergraduates who voluntarily agreed to explain the purpose of the study from February 15, 2021 to February 28, 2021, and were analyzed through structural equation modeling. Results The main research finding were as follow: First, motivation of procrastination, self-handicapping, anxiety, depression and procrastination showed positive correlation. Second, the motivation of procrastination has a direct effect on the self-handicapping, and it has been shown th affect self-handicapping through anxiety and depression. Third, motivation of procrastination directly affects procrastination and affects procrastination through anxiety and depression. Conclusions It will be used as a data that can be applied to better understand the appearance of procrastination according to motivation of procrastination and to intervene and understand procrastination problems in counseling and clinical scenes.

서울시 소규모 재건축 사례 분석 - 빈집 및 소규모 재건축에 관한 특별법 개정 후의 공동주택 사례 중심으로 -

이시원(Lee, Si-Won),류지원(Ryu, Jiwon),주범(Chu, Beom) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.2

Currently, the ratio of housing types of citizens nationwide, excluding apartments and residences other than houses, is 47.3%. And as the times go by, many old complexes that are more than 20 to 30 years old appear throughout the city. Even houses over 40 years old can be easily seen. These buildings, which have structural and safety problems, need to be reconstructed and redeveloped. In addition, buildings without structural problems need to be remodeled according to the degree of deterioration in appearance and changes in the way of life of residents. Among the various architectural improvement plans for old complexes, cases of small-scale reconstruction applied were compared and analyzed.

원자현미경 (AFM)을 이용한 환경오염물질에 노출된 HeLa 세포의 표면변화 연구

이시원(Si-won Lee),이수일(Soo il Lee),최진희(Jinhee Choi) 환경독성보건학회 2008 환경독성보건학회지 Vol.23 No.1

The toxicity of environmental pollutants was measured between a image of the surface topography in HeLa cells using atomic force microscopy for the possibility of toxic effect measurement and environmental monitoring. A image of the surface topography by AFM were estimated as toxic endpoints. The surface topography by AFM was observed a change of the cell surface in the environmental pollutants, but the standard of the measurement requires for the dose-effect degree. The overall results indicate that the possibility of measurement using AFM were confirmed a dose-effect degree related toxic effects, but it requres correlation between more various biomarker and AFM's measurements if the possibility of the toxic effect measurement was established.

노후도로 재정비 사례를 통한 입체적 도심 구축계획 - 지상 도로 지하화를 중점으로 -

이시원(Lee, Si-Won),유지원(Ryu, Jiwon),주범(Chu, Beom) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.1

As the population increases, so does traffic. This is expected to lead to a sharp increase in the number of roads on the ground. To this end, the government will remove and remodel old roads in the past and turn them into underground, thereby creating parks and green spaces for citizens to restore the disconnection of the city center and improve the quality of urban infrastructure. Furthermore, by undergrounding the roads, the city becomes three-dimensional, and it is expected to create a walking space and a public space.

국립대학 법인화 정책의 형성과정에 대한 연구 -일본의 국립대학 법인화 정책 사례를 중심으로-

이시원 ( Si Won Lee ),명성준 ( Sung Jin Myung ) 한국정책학회 2010 韓國政策學會報 Vol.19 No.3

곰팡이 균의 생성 과정을 활용한 바이오 패턴 디자인

이시원 ( Si-won Lee ) 한국디자인트렌드학회 2017 한국디자인포럼 Vol.56 No.-

연구배경 생명체의 이미지에 대한 과학의 관심은 과학기술의 발전과 더불어 예술의 경계 확장에 지속적으로 영향을 미치고 있다. 만약 육안으로 확인 불가능한 대상까지 예술가가 볼 수 있다면, 창조적 발상의 토대를 넓힐 수 있는 방식이 될 수 있을 것이다. 그러므로 과학실험실 도구의 활용은 예술가에게 미적 도구로서의 가치가 있고, 과학적인 실험 방법은 예술가의 창작 과정에서 새로운 방법으로 시도될 수 있다. 연구방법 현대미술에서 나타난 과학적인 사고와 배경에 대해 조사한다. 특히 생명체를 가지고 표현한 작가와 작품을 중심으로 알아본다. 연구자의 작업을 위한 실험실에서의 계획과 실천을 구상하고, 실험 후에 얻어진 과학적인 사실과 지식으로 패턴을 만들기 위해 특징을 찾는다. 실험실의 광학현미경으로 직접 보았던 이미지 자료에서 형태를 구분하여 직접적인 모티브로 시용하여 패턴을 만든다. 연구결과 과학적인 실험방식은 예술가에게 미적으로 뜻하지 않은 결과를 얻는 새로운 방법이 될 수 있었다. 불쾌한 존재로 여겼었던 곰팡이는 실험에서 알게 된 생성과 소멸의 생명 순환으로 나타나 `생명력`으로 의미를 갖게 되었고, 그 생명력의 생식과 번식은 패턴으로 만들어 표현하기에 적합하였다. 결론 과학적인 관찰 방법을 통해 눈으로 볼 수 없었던 살아 있는 생명체를 관찰하고 그 생명력을 추상적인 바이오 패턴으로 표현할 수 있었다. 예술의 경계와 영역이 확장되고 있는 현재, 본 연구가 섬유 예술 분야에서 향후 다양하고 새로운 창작 방법이 될 수 있기를 기대해 본다. Background Interest of science on the image of life continuously influences in the expansion of boundary of art including the development of scientific technology. If artists can see objects that cannot be identified by naked eyes, it would be a way of expanding the base of creative thinking. Therefore, use of science lab tools is valuable to artists as aesthetic instruments and the scientific experiment method could be tried as a new method in the process of artists` creation. Methods It researches the scientific thinking and background appeared in the modern art. Especially, it focuses on artists and their works which expressed with life. It designs the plan and practice in the lab for researchers` work and looks characteristics to make a pattern with the scientific facts and knowledge achieved after the experiment. From the image materials seen with the optical microscope of the lab, it sorts out their types and makes a pattern using the material as a direct motive. Result The scientific experiment method could be a new way of getting unexpected aesthetic results for artists. The mold which was regarded as unpleasant became to have a meaning of `life` appearing as a life cycle of creation and extinction known in the lab and the reproduction and breed of the life was suitable to make and express as a pattern. Conclusion It could observe living creatures that cannot be seen by eyes through the method of scientific observation and express it as an abstract bio pattern. At present that the boundary and area of art are expanding, it is expected that this study would be a variety and new ways of creation in the art field in the future.

박과류 관련 종자전염 검역바이러스 3종의 PCR 진단시스템 개발

이시원 ( Si Won Lee ),민병대 ( Byung Dae Min ),이진영 ( Jin Young Lee ),신용길 ( Yong Gil Shin ),이수헌 ( Su Heon Lee ),정원화 ( Weon Hwa Jheong ) 한국미생물생명공학회(구 한국산업미생물학회) 2015 한국미생물·생명공학회지 Vol.43 No.1

박과는 스쿼시, 호박, 애호박, 조롱박, 오이 및 수박 등 100여 속이 넘는 속이 포함된 식물과이며, 종자의 수입량이 매우 많은 작물이다. 이들이 우리나라로 수입될 때, 규제바이러스인 Squash mosaic virus (SqMV), Cucumber green mottle mosaic virus (CGMMV) 및Kyuri green mottle mosaic virus (KGMMV)에 대하여 검역을 수행한다. 본 연구에서는 SqMV, CGMMV 및 KGMMV를 신속·높은 감도로 검출할 수 있는 특이적 RT-PCR 및 nested PCR 프라이머 조합과 유전자변형-양성대조구 플라스미드를 개발하였다. 또한 본 연구에서 개발한 진단시스템을 2010년부터 2014년 상반기까지 현장적용하여, SqMV 47건, CGMMV 67건 및 KGMMV 17건을 검출하였다. The Cucurbitaceae are a plant family that consist of over a hundred genera, the most important of which are squash, pumpkin, zucchini, some gourds, cucumber and watermelon. These are among the top imported seeds in Korea. At the time of their import, the Squash mosaic virus (SqMV), the Cucumber green mottle mosaic virus (CGMMV) and the Kyuri green mottle mosaic virus (KGMMV) are designated as regulated viruses for quarantine in Korea. This study was conducted to develop specific primer sets for easy and rapid detection of SqMV, CGMMV and KGMMV. RT-PCR with the nested PCR primer sets and modified positive control plasmids were capable of highly sensitive detection and verification of such viruses. In addition, developed diagnostic PCR systems applied to quarantine sites detected 47 cases of SqMV, 67 cases of CGMMV and 17 cases of KGMMV between 2010 and the first half of 2014.

소아 아토피 피부염에서 Cyclosporin의 치료효과

이시원(Si Won Lee),이용석(Yong Suk Lee),이승철(Seung Chul Lee) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.4

N/A Background:Atopic dermatitis is a chronic skin disease, most common in childhood. Severe atopic dermatitis may require the regular use of topical corticosteroids or systemic corticosteroids. These treatments are prone to several adverse side effects. Many studies have reported that short-term use of cyclosporin is a quite effective prescription for severe atopic dermatitis of adults. Unfortunately, there have been very few studies on the use of cyclosporin for children. Objective:The purpose of this study was to examine the effect of cyclosporin in treating severe atopic dermatitis of children. Mehtods:Thirteen children who had severe atopic dermatitis were treated with cyclosporin(Neoral , Norvatis). The dose of cyclosporin was 3mg/kg/day. The disease activity has been monitored on a weekly basis, based on changes in 6 parameters of sign; erythema, exudation, excoriation, dryness, cracking, and lichenification. We employed a measurement system in which six different sites(head and neck, hands, elbows, feet, legs, and trunk)were scored on 4 different scales; 0(none), 1(mild), 2(moderate), and 3(severe). In addition to parameters mentioned above, itching and sleep-disturbance were also monitored. These were assessed by patients or their parents in the same manner. Results:After 4 weeks of cyclosporin treatment, the significant reductions in mean severity scores and mean sysmptom scores were observed. The mean severity scores of 13 patients decreased from 42.0±13.3 to 14.0±13.1(p<0.01). The mean symptom scores of itching and sleep-disturbance decreased from 2.2±1.0, 2.1±1.0 to 0.8±1.0, 0.8±1.0(p<0.01), respectively. There were 6 events of adverse side effects throughout the study. Upper respiratory tract infection was the most frequent complication from 3 patients. Conclusion:In view of these findings, we conclude that cyclosporin is effective in the treatment of severe atopic dermatitis of children without serious complications. (Korean J Dermatol 2000;38(4):466~471)

의료기관 일반 공급부의 재난 상황에 대비한 동선 계획 연구 - K 종합병원을 중심으로

이시원(Lee, Si-Won),오윤택(Oh, Yun-Taek),김영애(Kim, Young-Ae),이현진(Lee, Hyun-Jin) 한국생태환경건축학회 2022 한국생태환경건축학회 학술발표대회 논문집 Vol.22 No.2