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새로운 1,2,4-Triazole 유도체의 합성에 관한 연구
김호식,박태주,도이향,이만길,창택가구,Kim, Ho Sik,Park Tae Joo,Doh Yi Hyang,Lee Man Kil,Kurasawa Yoshihisa 대한화학회 1992 대한화학회지 Vol.36 No.5
${\circo}-페닐렌디아민(3)을 출발물질로 하여 4단계를 거쳐 {\alpha}-arylhydrazonoacylazide(7)를 합성하였다. 얻어진 {\alpha}-arylhydrazonoacylazide(7)는 디메틸슬폭시드 용액에서 hydrazone imine형과 diazenyl enamine형으로 존재하는데 이들 사이의 토오토메리 현상을 ^1H-NMR 스펙트럼 데이타에 의하여 측정된 토오토머 비로서 고찰하였다. {\alpha}-arylhydrazonoacylazide(7)를 벤젠용매에서 환류시켜 1-aryl-3-quinoxalinyl-1,2,4-triazol(8)을 합성하였다.$ ${\alpha}-Arylhydrazonoacylazide(7) was synthesized starting from {\circo}-phenylenediamine(3) in four steps. The tautomeric behavior of {\alpha}-arylhydrazonoacylazide(7) between the hydrazone imine and diazenyl enamine forms in the dimethyl sulfoxide solution was investigated on the basis of the tautomer ratio determined by the ^1H-NMR spectral data. The 1-aryl-3-quinoxalinyl-1,2,4-triazol(8) was synthesized from {\alpha}-arylhydrazonoacylazide(7) by refluxing in benzene.$
새로운 1,2-다이아제피노 [3,4-b]퀴녹살린류와 피리다지노 [3,4-b]퀴녹살린류의 합성
김호식(Ho Sik Kim),이성욱(Seong Uk Lee),정극(Geuk Jeong),이만길(Man Kil Lee),Yoshihisa Kurasawa 대한약학회 2000 약학회지 Vol.44 No.4
The 1,3-dipolar cycloaddition reaction of the quinoxaline 4-oxides 2 with 2-chloroacrylonitrile gave the 2,3-dihydro-1H-1,2-diazepino[3,4-b]quinoxalines 3, which were converted into the 2,3,4,6-tetrahydro-1H-1,2-diazepino[3,4-b]quinoxalines 5-7. The reaction of compounds 3 with selenium dioxide in acetic acid/water resulted in ring transformation to give the 1,4-dihydro-4-oxopyridazino[3,4-b]quinoxalines 8.
2-(Pyrazol-1-yl)quinoxaline류 및 2,3-Di(pyrazol-1-yl)quinoxaline류의 합성
김호식(Kim, Ho-Sik),정원영(Jeong, Won-Young),최경옥(Choi, Kyung-Ok),이성욱(Lee, Seong-Uk),곽삼탁(Kwag, Sam-Tag),이만길(Lee, Man-Kil) 대한화학회 2002 대한화학회지 Vol.46 No.1
3,6-Dichloro-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(8)또는 6-chloro-3-hydrazino-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(9)을 치환 아닐린류, 슬파제 및 heteroacyl chloride류와 반응시켜 2-(pyrazol-1-yl)quinoxaline류(10-12)를 합성하였다. 그리고 화합물 9를 alkyl (ethoxymethylene)cyanoacetate류와 반응시켜 분자내 고리화반응에 의하여 2,3-di(pyrazol-1-yl)quinoxaline류(13)를 합성하였다. The reaction of 3,6-dichloro-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(8) or 6-chloro-3-hydrazino-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(9) with substituted anilines, sulfa drugs and heteroacyl chlorides gave 2-(pyrazol-1-yl)quinoxalines(10-12). The reaction of compound 9 with alkyl (ethoxymeth-ylene) cyanoacetates resulted in the intramolecular cyclization to give 2,3-di(pyrazol-1-yl)quinoxalines(13).
Halogeno Benzothiazolyl Sulfonamide 誘導體의 合成과 抗菌作用에 關한 硏究
徐丙天,李萬佶 嶺南大學校附設 基礎科學硏究所 1981 基礎科學硏究 Vol.1 No.-
Four benzothiazolyl sulfonamide derivatives have been newly synthesized by reacting 2-aminobenzothiazole or 2-amino-6-halogenobenzothiazole with acetamidobenzenesulfonylchloride, respectively. The structures of these compounds were determined by the elementary analysis, melting point and IR spectrophotometry. These compounds exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli in concentration of 100㎍/ml, showing stronger activity against Staphylococcus aureus(Gram positive)than that against Escherichia coli (Gram negative). The difference in the antibacterial activity according to the substituted group(chloro, bromo, fluoro) was also noted. The chloro substituted compound exhibited more potent growth-inhibitory activity against above two strains than any other compound.
영도구 내 식수로 이용되는 약수의 화학적 및 생물학적 성분에 관한 연구
김양,김두호,조현구,이만길 고신대학교 영도발전연구소 1999 영도연구 Vol.1 No.-
The industrial development and the populous cities have made environmental pollutions more serious. Especially, the industrial activities result in accumulation of polluted heavy metals in the body of organisms through the food chain, leaving extensive damages. Most of the residents in Youngdo-Gu(District). Pusan use mineral water around Mt. Bongnae as drinking water. It is very important that the chemical components and the level of bioligical pollution in the water should be tested for the health of the residents in Youngdo district as well as the rest of Pusan people who use the water. Thes study conducted 4 tests on the quality of mineral water in 8 spas around Mt. Bongnae at the monsoon (July to September) and at the dry season (May, June, October and November), respectively. It examined the chemical and biological components in the mineral water: the amount of chemical components such as Ammonia-Nitrogen. Nitrite-Nitrogen, Chemical Oxygen Demand, Cadmium(Cd), Cromium(Cr). Manganese(Mn). Lead(Pb), Zinc(Zn), and Copper(Cu) as well as the amount of biological components such as General Bacteria and Escherichia coli group. The mineral water in 4 spas out of the 8 spas tested had a positive response to Escherichia coli group. The water in the S-Ⅱ spa contained Escherichia coli group in the dry season of october and November. with the number of General Bacteria similar to that of the rest places. The mineral water in the BA and SJ spa showed a positive response to Escherichia coli group. The Escherichia coli group was detected in the BS mineral water that many residents used as drinking water. The YH mineral water contained no Escherichia coli group. with relatively more General Bacteria in the dry season of November. However, the level of the number of General Bacteria was below the allowance-value. None of the 4 spas that showed a positive responsee to Escherichia coli group were appropriate for drinking before boiling. All the places tested had no heavy metal. but they had various chemical components and General Bacteria below the allowance-value.