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쥐 해마에서 글루타메이트의 시간에 따른 변화가 급성 스트레스 연구에 미치는 영향 : 자기공명분광학을 이용한 연구
연제형(Jehyeong Yeon),윤창수(Chang-Soo Yun),황윤호(Yoonho Hwang),백현만(Hyeon-Man Baek),김동윤(DongYoun Kim),한봉수(Bong Soo Han) 대한전자공학회 2021 대한전자공학회 학술대회 Vol.2021 No.6
It was reported that rodents were significantly influenced by stress from experimental procedure and by isoflurane anesthesia. Therefore, in MRS experiments in the hippocampus of normal mice, the concentrations of Glu and tCho were observed to decrease over time. Glu is a potential stress biomarker and its concentration increases with stress. The purpose of this study is to investigate the effect of the time delay that may occur during 1H-MRS experiments on acute stress studies by comparing the control group and the stress group. 20 C57BL/6N male mice were grouped into the control group and the stress group. The stress group mice were exposed to acute constrain stress, and 1H-MRS data were obtained from the left hippocampus, and the difference in the concentration of metabolites due to stress was compared. We found that the statistical significance of the difference in Glu concentration between the two groups changed if there was a difference of about 17 minutes in the data collection time between the two groups. In conclusion, the results of this study suggest that it is necessary to avoid the difference in the timing of data collection between the control and experimental groups in stress studies.
항결핵성 Naphthyridine 유도체들의 2D QSAR
조창희,이상호,윤창수,김필호,최민성,명평근 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-
Antituberculosis activities of naphthyridine analogues were found to be in the range of pI50=5.02~6.87 with average inhibitor activity of pI50=5.79. The compound with the highest inhibitor activity was compound 28 (Obs.pl50=6.87) and that with the lowest inhibitor activities was compound 3 (Obs.pl50=5.02). And also, the deviation between the highest inhibitor activity and the lowest inhibitor activity was pI50=1.85. 2D-QSAR model (Ⅰand DI) was the best model as determined by Neuro network and PLS analysis. As naphthyridine analogues were smaller in GP0 (GP0>0), lager in GP1 (GP1<0) and MR6 (MR6>0)with logP (logP>0) were smaller and lager vpol (vpol<0), the inhibitory activities against M. TB was increased. Especially the molar refractivity (MR) of substrate molecules was shown more steric effect than polarizability.