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RISS 인기검색어
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- 저자 : 유항종(Hang Jong Yoo) (검색결과 4 건)
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서상범(Sang Beom Suh),서병조(Byoung Jo Suh),김준희(Joon Hee Kim),유항종(Hang Jong Yoo) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.4
Purpose: Docetaxel (Taxotere<SUP>ⓡ</SUP>) and capecitabine are used in combination to treat advanced gastric cancer. Thymidine phosphorylase (TP) is an essential enzyme for the activation of capecitabine in tumors. This study sought to identify the best combination therapy with capecitabine and using two different schedules for docetaxel, a TP up-regulator, to enhance capecitabine’s efficacy. Methods: The human gastric cancer cell line SNU-484 was cultured and docetaxel (2㎍/㎖) was added to the 24-well plates that contained 5×105 cells/well. The total RNA was isolated and RT-PCR was done to identify the TP expression. Four- or five-week-old BALB/c-nu/nu mice were subcutaneously inoculated with the SNU-484 cells. The nude mice were divided into two groups and they were given capecitabine 539 ㎎/㎡ p.o. from days 1 to 14: Group 1 was given docetaxel 15 ㎎/㎡ i.v. on day 1; Group 2 was given docetaxel 7.5㎎/㎡ on days 1 and 8. Tumor tissues were excised on days 1, 8 and 15 to measure the TP and bcl-2 levels. Results: TP was expressed 2 hours after docetaxel administration. Group 2 had a higher TP concentration in the tumor tissues and a better antitumor effect than did Group 1. There was no difference in the bcl-2 concentration in the two groups. Conclusion: These results suggest that docetaxel stimulates the TP expression in tumor tissues and it enhances the antitumor activity of capecitabine. A weekly docetaxel injection with capecitabine administration can be used to treat gastric cancer more effectively than when docetaxel is injected once per cycle. Capecitabine had no bcl-2 suppressive effect in this study.
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위선암에서 p53 단백의 과발현과 임상 및 병리학적 예후인자와의 상관관계
서병조,유항종,이주호,주미,이혜경,김진복 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2
Objective: Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumor progression. Wild-type p53 negatively regulates the cell cycle; a loss of function by mutation might be expected to result in enhanced proliferating activity and tumor progression. A large number of immunohistochemical studies have confirmed p53 accumulation to be a very common feature of human malignancy. The aim of the present study was to determine whether p53 status in gastric cancer is correlated statistically with various histopathological indicators or not. Methods and Materials: A total of 197 surgically resected gastric adenocarcinomas were examined to determine whether a correlation exited between immunohistochemical expressions of the p53 protein and other histopathological factors. Results: p53 overexpression was observed in 46.2% of the gastric cancers. Overexpression of p53 was correlated with vascular invasion of gastric cancer(p=0.004). In early gastric cancer, the p53 overexpression rate was 42.3%, and of them, a correlation was found between the intestinal type of the Lauren classifcation(p=0.013) and histologically differentiated gastric cancer(p=0.014). Conclusion: p53 overexpression was significantly correlated with vascular invasion of gastric cancer. In cases of early gastric cancer, p53 overexpression was correlated with Lauren classification and differentiation. These results suggest that p53 mutation plays an important role in carcinogenesis in gastric adenocarcinomas. Further study in needed to determine the correlation between p53 overexpression and the prognosis for the gastric cancer patient.
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서병조,김태현,이주호,유항종,김진복 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3
Benign papillary mesothelioma in peritoneum is very rare lesion which is often found incidentally in abdominal surgery. Gross findings are similar to dissemination of intraabdominal malignant lesion, so it is hard to make differential diagnosis between them. Benign papillary mesothelioma is not related with exposure of asbestos which is related with development of malignant mesothelioma. To make differential diagnosis between peritoneal seeding of malignant lesions and benign papillary mesothelioma, it is often necessary to do frozen biopsy during abdominal operation. The patient was 53-year-old man and was transferred to KGCC under the diagnosis of advanced gastric cancer in private clinic. In gastrofiberscopic examination. pylorus was completely obstructed with Borrman Ⅲ gastric cancer. Operation findings revealed complete obstruction of antrum and serosal invasion, enlargement of number 8 lymph node, 0.5㎝ sized multiple nodules in mesentery of small bowel and colon and frozen biopsies of nodules were made and no cancer cell was noted. We did radical subtotal gastrectomy with D2 lymph node dissection. Adjuvant chemotherapy with protocol(Picibanil 1.0K.E, Mitomycin 4㎎, 5-FU 500㎎) was started after 8 days of operation and discharged after 21 days of operation.
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