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궤양성 대장염 환자에서 혈청 Interleukin-10과 Interleukin-12 측정에 의한 Th1/Th2 반응의 평가
최성규,김태연,김현수,주영은,김세종,유종선,서강석,민상운,유상두 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1
Background/Aims: Previous studies showed that ulcerative colitis (UC) was a T-helper 2 (Th2) response dominant disease while Crohn's disease was a T-helper 1 (Th1) response dominant disease. In this study, we evaluated the Th1 and Th2 reponses by measuring the serum levels of interleukin (IL)-10 and IL-12 in patients with UC and normal controls. Methods: Serum concentrations of IL-10 and IL-12 were measured using an enzyme linked immunosorbent assay in 24 patients (15 with mild to moderatie disease, 9 with severe disease) with UC and 11 healthy controls. Results: The serum concentrations of IL-10 in patients with UC were significantly higher than those of controls (P$lt;0.05), while the concentrations of IL-12 in the patients were significantly lower than those of controls (P$lt;0.05). Additionally, the serum concentrations of IL-10 and IL-12 were not closely related to the severity of the disease. Conclusions: The above results suggest that UC may be resulted from dysregulation of Th1 and Th2 immune response. However, there was no definite correlation between the severity of disease and the level of IL-10 or IL-12.