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김용진(Yong Jin Kim),박성환(Sung Hwan Park),주대현(Dae Hyun Joo),이한일(Han Il Lee),유용운(Young Oon Yoo),박기호(Ki Ho Park),이진우(Jin Woo Lee),김양일(Yang Il Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
The authors experienced a case of diffuse gastric polyposis with focal malignant transformation. A 61-year-old male visited this hospital because of epigastric pain. The gastrofibroscopic examination showed numerous polyps in entero-gastric mucosa mainly in the antrum and confirmed malignant change from one of the largest polyps in the antrum in the preious gastrofibroscopic examination dane six years ago. There was no family history of gastrointestinal polyps and the colon of this patient was intact. The total numbers of polyps was numerous, about 300, or more in the gastrectomized specimen. The size of polyps are variable, from less than 1mm to over 10mm, the largest one being 1,2cm * 0.5cm, but most of them were less than 0.3cm. The polyps were seattered in the fundus, cardia, body and antral portion of the stomach, but located mainly in the antrum, about 80% or more. All of the polyps were sessile. Microscopically, focal dysplastic changes and rnalignant changes were found in the superficial layer of the mucosa, which were located in the antrum. The remsining mucosa showed chronic atrophic gastritis associated with intestinal metaplasia, The hyperplastic gastric polyps comprised of appoximatcly 75% of all gastric epitheiial polyps. A coincident gastric carcinoma was repotted in 1.7%-2% patients with hyperplsatic polyps, Carcinoma lesions could be classified as type IIa early gastric cancer. At operation, there were no enlarged regional lymph nodes, and the other intraaMominal organs were intact grossly. There were no metastatic tumors in 35 dissected regional lymph nodes. The D2, total gastrectamy, Roux-En-Y, was performed, and the patient recovered uneventually (Korean J Gastroenterol 1997; 29:274 - 278)
김강도,주대현,유용운,박성환,박기호,박재복,Kim, Gang-Do,Joo, Dae-Hyun,Yoo, Yong-Oon,Park, Sung-Hwan,Park, Ki-Ho,Park, Jae-Bok 대한소아외과학회 2002 소아외과 Vol.8 No.1
Infantile hypertrophic pyloric stenosis (IHPS) a common childhood disorders characterized by nonbilious projectile vomiting, an olive shaped mass in the right upper quadrant of the abdomen and visible gastric peristaltic wave in the upper abdomen. Its etiology and pathogenesis are not clear but abnormal nerve distribution of the pylorus has been $postulated^{2-6}$. We performed immunocytochemical staning to the pyloric muscle from 10 IHPS and 3 controls patients, utilizing specific monoclonal antibody to NCAM(neural cell adhesion molecule). In IHPS patients, the number of NCAM protein immunoreactive nerve fibers were less than that in normal subjects. Auerbach myenteric plexuse was well developed and interbundle nerve plexuse was present but nerve fibers supplying individual muscle cells in smooth muscle bundles were poorly developed. These results indicate reduction of innervation in smooth muscles in IHPS patients that possibly contributes to the pathogenesis of IHPS.