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알레르기질환 및 아토피피부염에서 가려움증의 병인 및 치료적 접근
원종현 ( Chong Hyun Won ),홍승필 ( Seung Phil Hong ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.3
Pruritus, briefly defined as an unpleasant sensation provoking the desire to scratch, is a major characteristic and one of the most debilitating symptoms in allergic diseases and atopic dermatitis. Although recent observations have clearly improved our knowledge of the pathophysiology of pruritus, it is still too complex involving neurophysiological and neuroimmunological aspects. In this review, we summarize the current information regarding the role of mediators and receptors related to trigger or inhibit pruritus, and the management of pruritus in allergic and atopic disease. (Korean J Asthma Allergy Clin Immunol 2010;30:184-192)
인체 모낭에서 TGF-β 발현에 대한 면역조직화학적 연구
원종현 ( Chong Hyun Won ),주영현 ( Young Hyun Joo ),이동훈 ( Dong Hun Lee ),안지수 ( Jee Soo An ),김범준 ( Beom Joon Kim ),권오상 ( Oh Sang Kwon ),조광현 ( Kwang Hyun Cho ),김규한 ( Kyu Han Kim ),은희철 ( Hee Chul Eun ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.4
Background: Although it is well known that transforming growth factor beta (TGF-β) may induce catagen change of hair follicles and inhibit hair growth, it is still unclear which subtype of TGF-β and its specified receptor might be expressed in human hair follicles of androgenetic alopecia (AGA) patients. Objective: To delineate precise expression of TGF-β subtype in human hair follicles of androgenetic alopecia patients. Methods: Immunohistochemical studies were performed on paraffin sections of human hair follicles by applying type 1, 2, and 3 TGF-β antibodies and type I and II receptor antibodies. We ascertained the expression of TGF-β subtype in hair follicles of androgenetic alopecia patients. We also compared the expression pattern of each type of TGF-β receptor. We evaluated the change of TGF-β expression of hair follicles in the catagen phase. Results: TGF-β1 was well-expressed in the outer area of the inner root sheath (IRS) or dermal connective sheath area. TGF-β2 was commonly expressed in the inner 1/2 of the outer root sheath (ORS). TGF-β3 was expressed in the hair cortex, IRS, and cuticle in normal hair follicles obtained from both the vertex and occipital area. On the contrary, in specimens from AGA, the enhanced expression of type 2 TGF-β or type II receptor was observed in the vertex area (bald) compared to the occipital area (non bald). When the expression patterns of TGF-β 1, 2, and 3 were compared between anagen and catagen phases, TGF-β2 and 3 were positively expressed in the epithelial strands and secondary hair germs in the catagen phase. The immunoreactivities of TGF-β 1 and 2 were intensified in the ORS areas of the catagen phase. Conclusion: The expression of type 1, 2 TGF-β and type I and II receptors in follicular epithelial cells might be related to catagen induction and development of androgenetic alopecia of human hair in vivo. (Korean J Dermatol 2007;45(4):321~326)
Educational Lecture 2-1 (EL 2-1) : Surgical anatomy of head and neck area
원종현 ( Chong Hyun Won ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Dermatological surgeons must have an in-depth understanding of the regional head and neck anatomy to achieve good surgical outcomes and avoid complications related to procedures. Ideal cosmetic procedures such as botulinum toxin and filler injections and surgical procedures (skin biopsy, excision, etc) are possible based on in-depth knowledge of head and neck anatomy. The anatomy of the head and neck is complex. There are cosmetic boundaries, which should be preserved as much as possible and remove additional tissue to place incisions at the junction of cosmetic unit during facial surgery to minimize the distortion of face. There are several danger zones in the head and neck area where the nerves or arteries travel more superficially. It is important to recognize the danger zones to minimize the risks of arterial bleeding (the frontal branch of temporal artery at the temple, the facial artery as it crosses the mandibular rim, the angular artery as it courses near the nose) and nerve transaction (the temporal branch of the facial nerve, the spinal accessory nerve in the posterior triangle of the neck, the marginal mandibular nerve as it courses in the neck below the mandible) , and preserve the cosmetic units of the face during surgery. The surgical risk of injury to nerves or other relevant anatomic structures should be discussed with the patient preoperatively, and informed written consent should be obtained. In addition, we should be aware of where to perform nerve blocks (supraorbital, infraorbital, and mental nerve foramina). This lecture will discuss how to identify the anatomical danger zones in the head and neck area and how to apply knowledge of head and neck anatomy in dermatologic surgical procedures.
원종현 ( Chong Hyun Won ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
1. HF development는 complex interactions between epithelial and mesenchymal cells에 의함 2. HF development에 중요한 유전자들이 Hair cycle과 모발 형성 및 성장에서도 중요함 3. Molecular regulation of HF morphogenesis (8 distinct stage) 1) stage 1 Hair germ/mesenchymal condensation; EDA, EDAR,BMP/ Wnt 5a, Lef-1, Ptc1, Gli1, noggin, versican 2) stage 2 Hair peg; Shh / mesenchymal condensation (basal cell nevus syndrome . patched gene deficiency) 3) stage 5 Differentiating outer sheath; CK5, CK 14 Differentiating inner sheath; CK1, CK10, Loricrin, Involucrin, transglutaminase Differentiating hair shaft; Hair keratins, Lef-1, Hoxc13, Foxn1, Msx-2, Notch, Jagged 1/2 Dermal papilla; BMP-2, BMP-4, noggin, KGF, HGF, SCF, versican, Alkaline phosphatase 4) stage 8 Sebaceous gland; TCF3, BMPR-IA Bulge; CK15, CK 19, BMP 6, Cremlin Melanogenic area; SCF, c-kit Dermal papilla; BMP-2, BMP-4, noggin, KGF, HGF, SCF, versican, Alkaline phosphatase 4. Cell lineage development에서 transcriptional factor의 변화로 분화의 방향 정해짐 Wnt, LEF 1 상승; Hair cell / Shh, Myc 상승, Wnt 감소; sebocyte로 발달 Transgenic mice model; intact WNT singnaling -> hair / inhibition of WNT signaling -> less hair Blocking Shh signaling / activating Shh signaling -> size, number of sebaceous glands 결정
원종현 ( Chong Hyun Won ),윤재일 ( Jai Il Youn ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.11
Background: Chronic actinic dermatitis (CAD) has been defined using three criteria: clinical photobiological and histological aspects. CAD is a rare disease with only a few clinical analyses reported in Korea. Objective: The purpose of this study was to investigate the clinical characteristics of CAD including epidemiology, clinical presentations and results of phototests in Korean patients. Methods: A retrospective analysis was conducted according to patients` medical records at Seoul National University Hospital. Results: Twelve patients were enrolled in this study. Most were elderly men with skin lesions on the sun-exposed areas. The mean age was 55. 4 years. Ten patients were male and the other 2 were female. The mean duration of the disease was 12.7 years. Phototests showed that 6 patients showed decreased minimal erythema dose (MED) to UVA and 2 patients decreased MED to UVB. The remaining 4 patients decreased to both UVA and UVB. Conclusion: The most common abnormal phototest results were decreased MED to UVA. More patients showed normal MED to UVB in this study compared with other studies. Our study analyzed the clinical and photobiological characteristics of CAD in Korean patients. (Korean J Dermatol 2007;45(11):1144∼1148)