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신중곤,정현섭,제이슨 용하 김,김영효,한창수,김지온,김혜돈,김영훈,정면우,한순영,신형두 대한의학회 2013 Journal of Korean medical science Vol.28 No.8
Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent for cancer. In order to determine the genetic distribution of DPYD, we directly sequenced 288 subjects from five ethnic groups (96 Koreans, 48 Japanese, 48 Han Chinese,48 African Americans, and 48 European Americans). As a result, 56 polymorphisms were observed, including 6 core polymorphisms and 18 novel polymorphisms. Allele frequencies were nearly the same across the Asian populations, Korean, Han Chinese and Japanese,whereas several SNPs showed different genetic distributions between Asians and other ethnic populations (African American and European American). Additional in silico analysis was performed to predict the function of novel SNPs. One nonsynonymous SNP (+199381A > G, Asn151Asp) was predicted to change its polarity of amino acid (Asn,neutral to Asp, negative). These findings would be valuable for further research, including pharmacogenetic and drug responses studies.
Detectability Test of H2 Lyman-Werner Band Emission for Far-Ultraviolet Imaging Spectrograph, FIMS
선광일,경욱 민,광선 유,대희 이,수종 박,승한 오,용선 박,용하 김,욱원 남,한원용,인수 육,장현 박,종호 신,호진,Eric J. Korpela,Jerry Edelstein,Kaori Nishikida 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.42
Molecular hydrogen (H2) is excited by far-ultraviolet (far-UV) photons and emits uorescent emission in the far-UV bands and in the near- and the mid-infrared bands. Observations of H2 in these photodissociation regions (PDRs) are important in tracing star-forming molecular clouds and in understanding the interaction between newly born stars and molecular clouds. We use the typical PDR model of Sternberg to estimate the observing time (or integration time) required to detect PDRs with the Far-ultraviolet IMaging spectrograph (FIMS) onboard KAISTSAT-4, the rst Korean scientic satellite. The observing time is calculated using a formula based on a rigorous hypothesis testing for the detection limit, in contract to the often-used signal-to-noise ratio. The estimated observing time is also compared with the expected exposure time from one-year all-sky survey.