제2형 당뇨병 환자에서 Vitamin D와 HbA1c 및 Fructosamine과의 관련성

오혜종 ( Hye-jong Oh ),류소연 ( So-yeon Ryu ),박종 ( Jong Park ),한미아 ( Mi-ah Han ),최성우 ( Seong-woo Choi ) 한국보건정보통계학회(구 한국보건통계학회) 2019 보건정보통계학회지 Vol.44 No.1

Objectives: Although previous studies reported an association of serum vitamin D with glycated hemoglobin (HbA1c) and fructosamine, the relationships remain unclear. Therefore, this study aims to identify the relationships of serum vitamin D with HbA1c and fructosamine independent of parathyroid hormone (PTH) in Korean type 2 diabetic patients. Methods: Total 227 adults (male 112 and female 115) who treated for type 2 diabetes in a general hospital participated in this study. The serum vitamin D, HbA1c, fructosamine and fasting blood glucose (FBG) were measured in participants who met the detailed inclusion criteria. The level of serum vitamin D was defined as follows; deficient: <10.0 ng/mL, insufficient: 10.0-19.9 ng/mL, optimal: ≥20.0 ng/m. Results: In the analysis of covariance, after adjusted for other covariates including PTH, the means (standard error, SE) values of HbA1c became lower with higher serum vitamin D level (deficiency: 7.8 [0.2]%, insufficient: 7.5 [0.1]%, optimal: 7.2 [0.1]%, p=0.015). Also, after adjusted for other covariates including PTH, the mean (SE) values of fructosamine became lower with higher serum vitamin D level (deficiency: 357.1 [13.1] μmol/L, insufficient: 344.5 [4.9] μmol/L, optimal: 313.3 [6.4] μmol/L, p=0.001). However, the mean values of FBG were not significantly associated with the serum vitamin D level. Conclusions: There were significant associations of vitamin D with HbA1c and fructosamine independent of PTH, but there was no association of vitamin D with FBG in Korean type 2 diabetic patients.

당뇨병이 없는 비만 성인의 hs-CRP 수준과 FBG, Fructosamine 및 HbA₁c와의 관련성

오혜종 ( Hye Jong Oh ),최철원 ( Cheol Won Choi ) 대한임상검사과학회 2018 대한임상검사과학회지(KJCLS) Vol.50 No.2

본 연구는 국민건강영양조사 자료를 이용하여 당뇨병이 없는 성인 4,734명을 대상으로 비만 성인의 hs-CRP와 혈당조절 지표들과의 관련성에 대해 알아보고자 하였다. 연구결과 BMI가 증가할수록 혈당조절지표인 FBG와 fructosamine 및 HbA₁c가 증가하였으며, hs-CRP는 비만 군에서 가장 높은 수치를 보였고, 인슐린저항성의 지표인 HOMA-IR도 비만 군에서 통계적으로 유의하게 증가하였다. 또한 hs-CRP 수준을 구분하여 혈당조절지표들과의 관련성을 확인한 결과 hs-CRP가 증가할수록 FBG, fructosamine 및 HbA₁c가 증가됨을 확인하였고, 여러 관련 변수를 보정한 후에도 hs-CRP가 증가할수록 FBG, fructosamine 및 HbA₁c가 통계적으로 유의하게 증가하였다. 결과적으로 비만과 hs-CRP, 혈당조절지표는 각각에서 연관성을 보여 당뇨병이 없는 성인 중 높은 BMI에서 증가된 hs-CRP에 의해 당뇨병의 주요한 병인인 인슐린 저항성을 증가시켜 혈당조절지표인 FBG, fructosamine 및 HbA₁c가 통계적으로 유의하게 증가한 것으로 사료된다. 이에 당뇨병이 없는 성인에서도 올바른 식습관 및 규칙적인 운동으로 비만을 예방하여 당뇨병 발생을 감소시키는 노력이 강구되어야 하겠다. Obesity has been reported to be a cluster of risk factors in the pathological ecology, In particular, there is increasing evidence that inflammation-related factors are associated with diabetes. This study examined the relationship between the hs-CRP level and FBG, fructosamine, and HbA₁c in 4,734 non-diabetic adults aged 20 years or older, who were approved by the National Health and Nutrition Survey in 2015. The results showed that the FBG, fructosamine, and HbA₁c levels increased with increasing BMI; the hs-CRP levels were the highest in the obese group, and HOMA-IR, an index of insulin resistance, was also significantly higher in the obese group. The hs-CRP level was the highest in obese adults. The levels of FBG, fructosamine. and HbA₁c, which are involved in blood glucose control, increased with increasing hs-CRP level. The FBG, fructosamine, and HbA1c levels increased significantly with increasing hs-CRP level after adjusting for various related variables. These results suggest that the obesity-induced increase in hs-CRP is a risk factor for diabetes mellitus in non-diabetic adults. Therefore, proper dietary habits and regular exercise should prevent diabetes by preventing obesity in non-diabetic adults.

가을철 유행하는 급성열성질환의 혼합감염 양상

오혜종(Hye-Jong Oh),윤현(Hyun Yoon),최성우(Seong-Woo Choi) 한국콘텐츠학회 2012 한국콘텐츠학회논문지 Vol.12 No.12

본 연구는 가을철 급성열성질환인 쯔쯔가무시병의 단독감염과 신증후군 출혈열과의 혼합감염 시 임상증상 및 혈액검사의 양상을 보고자 전라남도 일개종합병원에서 최근 5년간 쯔쯔가무시병 혈청학적 확진검사에서 항체역가가 1:80이상인 양성 환자 221명을 분석하였다. 쯔쯔가무시병 단독감염 환자는 183명이며, 신증후군 출혈열과의 혼합감염 환자는 38명이었다. 연령별 환자발생은 70세 이상에서 가장 많이 발생하였으며, 성별 분포는 남성이 70명(31.7%), 여성이 151명(66.8%)으로 여성에서 다소 높았다. 발생 시기는 10월과 11월에 전체 발생율의 70% 이상을 차지하였다. 대상자의 임상증상은 발열(p=0.028)과, 가려움증(p=0.000), 근육통(p=0.000)에서 단독감염보다 혼합감염 시 유의하게 높았으며, 혈액검사 상 AST(p=0.000), ALT (p=0.000), 혈액요소질소(p=0.002), 총 빌리루빈(p=0.000)수치가 단독감염보다 혼합감염 시 유의하게 높았다. In this study, for behavior clinical signs and blood tests when autumn sudden fevered disease, Tsutsugamushi Disease is Single infected with mixing hemorrhagic fever with renal syndrom.221 positive patients, who have antibody titer more than 1:80 in serologic examination of Tsutsugamushi Disease in a general hospital, Jeollanam-do province, were adopted as a Analysis. in respect of frequency. Single infection patients of Tsutsugamushi Disease were 183 and mixed infection patients with Hemorrhagic Fever with Renal Syndrome were 38. In respect of age, patients over the 70s were mostly infected. In respect of sex, male patients were 70(31.7%) and female patients were 151(66.8%) Women were more infected than men. In respect of outbreak time, the more than 70% disease occurrence of all was charged in October and November and it also occurred in spring. In the clinical signs, fever(p=0.028), urtication(p=0.000) and muscle pain(p=0.000) of mixed infection was more higher than single infection. And in the blood tests, AST(p=0.000), ALT(p=0.000), blood urea nitrogen(p=0.002), total bilirubin(p=0.000) value of mixed infection was more higher than single infection.

비당뇨 교대근무자의 hs-CRP 수준과 혈당 관련 지표와의 관련성

오혜종(HyeJong Oh),박철(Chul Park) 한국보건기초의학회 2022 한국보건기초의학회지 Vol.15 No.1

This study analyzed the relationship between hs-CRP level and blood sugar-related indicators in 2,280 non-diabetic shift workers using data from the National Health and Nutrition Examination Survey. As a result of the study, FBG and HbA1c, which are blood sugar-related indicators, increased as BMI increased, and hs-CRP showed the highest level in the obese group. In addition, as a result of identifying the level of hs-CRP and confirming the relevance to blood glucose-related indicators, It was confirmed that as hs-CRP increased, FBG and HbA1c increased. Even after adjusting for related variables, as hs-CRP increased, FBG and HbA1c increased statistically significantly. As a result, obesity, hs-CRP, and blood sugar?related indicators were correlated, respectively. Among shift workers without diabetes, hs-CRP increased due to an inflammatory response due to obesity increased insulin resistance, a major cause of diabetes, so that FBG, a blood sugar-related indicator, and FBG, a blood sugar-related indicator, increased. It is considered that HbA1c increased statistically significantly. Therefore, even for shift workers without diabetes, efforts should be made to reduce inflammation and diabetes through early management to prevent obesity through proper eating and regular exercise.

65세 이상 관절염 여성노인의 체질량지수와 우울과의 관련성

오혜종(Hye-Jong Oh),류소연(So-Yeon Ryu) 한국엔터테인먼트산업학회 2015 한국엔터테인먼트산업학회논문지 Vol.9 No.1

본 연구는 2009년 지역사회건강조사 자료를 이용하여 65세 이상 관절염 여성노인 9,746명을 대상으로 체질량지수와 우울과의 관련성을 검토하고자 실시하였다. 연구결과 체질량지수에 따른 우울점수는 저체중군에서 36.2±8.9점, 정상군은 34.6±7.8점, 비만군은 34.7±7.8점으로 저체중군에서 우울점수가 유의하게 높아 관절염을 가지고 있는 저체중 여성노인이 우울정도가 가장 높은 것으로 나타났다. 또한 다중 회귀분석 결과에서도 저체중군이 정상군에 비해 우울점수가 유의하게 높았으며, 비만군은 정상군과 차이가 없었다. 결론적으로 관절염 여성노인에서 저체중이 우울에 영향을 주는 요인이었으며, 관절염을 가지고 있는 여성노인은 적절한 체중유지를 함으로써 우울을 예방하고 우울을 감소시킬 수 있을 것으로 기대된다. The purpose of this study was to identify the relationship between body mass index (BMI) and depression score in 9,746 elderly women over 65 years old with arthritis. Data from the 2009 Community Health Survey were analyzed for this study. As a result, the Mean depression score according to BMI level was found 36.2±8.9 in the under weight group, 34.6±7.8 in the normal weight group, and 34.7±7.8 in the obesity group, which showed that the highest depression score was found in the under weight group. The Multiple regression analysis showed the significant difference in the under weight group compared with normal weight group. However there was no significant difference between the obesity group and the normal weight group. These results suggest that under weight was a risk factor for depression level in elderly women with arthritis. Therefore, maintaining healthy weight should be considered to preventing the weight loss depression and to decrease in elderly women with arthritis.

Evaluation of Diseases Affecting Hindlimb Lameness in Domestic Small Breed Dogs

김동욱,황야원,유승원,오혜종,김근형 한국임상수의학회 2020 한국임상수의학회지 Vol.37 No.6

Lameness is a variation of normal gait in an animal, and it means that one or more limbs cannot be used correctly to allow the animal to walk. In the usual context, the incidence of hindlimb lameness in dogs is most likely the result of trauma, joint diseases, and/or congenital diseases. Generally speaking, the factors influencing hindlimb lameness include the animal’s specific breed, size, weight, and whether it engages in frequent or strenuous activities. Many studies have investigated the incidence of lameness of large breed dogs, as compared to small breed dogs. Considering that many domestic dogs are small breeds, the lameness of small breed dogs with a high population in Korea was evaluated. The major causes of hindlimb lameness were found to be joint, musculoskeletal, and neurological abnormalities and the most were identified as joint diseases. Among the joint diseases, it was noted that a patellar luxation was the most common, of which the grade 3 medial patellar luxation was the highest rated type of joint disease noted.

맥압과 t-score의 관련성

윤현(Hyun Yun),오혜종(Hye-Jong Oh),최철원(Cheol-Won Choi) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회논문지 Vol.7 No.1

본 연구는 일부 종합검진 수검자들을 대상으로 맥압과 t-score의 관련성을 검토하고자 2010년 1월부터 2011년 12월까지 G시의 일개 종합병원 건강검진센터에서 종합건강검진을 받았던 20세 이상의 지역주민 2,065명(남자 1287, 여자 778)을 분석대상으로 하였다. 연구결과에서 t-score에 양의 상관관계를 보이는 변수는 BMI(p<0.05), 체중(p<0.01)이었고, 음의 상관관계를 보이는 경우는 연령(p<0.01), 성별(p<0.01), 신장(p<0.01), HDL-C(p<0.05), FBS(p<0.01), SBP(p<0.01), PP(p<0.01), DBP(p<0.05)이었다. 연령, 성별, 신장,체중, TG, HDL-C, FBS, SBP, DBP, PP의 독립변수를 사용한 다중선형회귀분석결과에서 t-score에 영향을 주는 변수는 연령(p<0.001), FBS(p<0.001), 성별(p<0.01), PP(p<0.01), 체중(p<0.01)이었다. 결론적으로 PP의 증가는 t-score의 감소에 원인이었다. The purpose of this study was to investigate the association of osteoporosis and pulse pressure in health checkup examines. Study subjects were 2,065 adults of 20 years and over (1,287 males, 778 females), the health package check-up at the general hospital G from January, 2010 to December, 2012. t-score showed a significant positive correlation with BMI(p<0.05) and Weight (p<0.01), negative correlation with Age(p<0.01), Sex(p<0.01), Height(p<0.01), HDL-C(p<0.05), FBS(p<0.01), SBP(p<0.01), PP(p<0.01) and DBP(p<0.05). When a multiple linear regression analysis was performed, It was considered as the Age, Sex, Height, Weight, BMI, TC, TG, HDL-C, LDL-C, FBS, SBP, DBP and PP as independent parameters, t-score maintained a significant association only with Age(p<0.001), FBS(p<0.001), Sex(p<0.01), PP(p<0.01), Weight(p<0.01). In conclusion, Our results suggest that increase of PP might contribute to lower t-score.

천일염과 녹차를 발효시켰을 때 Catechin류의 추출량 변화

윤현(Hyun Yun),오혜종(Hye-Jong Oh),최성우(Sung-Woo Choi) 한국콘텐츠학회 2012 한국콘텐츠학회논문지 Vol.12 No.11

녹차를 천일염과 혼합하여 발효시킨 후 항균활성을 가지고 있고 셀룰라제가 없는 균종을 첨가하여 발효시킨 실험에서 녹차만을 발효시켰을 경우보다 천일염을 첨가하여 발효시킨 모든 시료에서 카테킨류인 EGC, EC, EGCG, ECG의 추출량이 증가하였고, 발효 일에 따른 분석에서는 EGC(epigallocatechin), ECG(epicatechin gallate), EC(epicatechin), EGCG(epigallocatechin gallate)모두에서 2일째와 3일째 높은 추출량이 검출되었다. 또한 발효균을 첨가하여 발효시켰을 경우 Paenibacillus spp에서는 모든 카테킨류(EGC, EC, EGCG, ECG)의 추출량이 증가하였고, Bacillus amyloliquefaciens에서는 EGC와 EC는 감소하고 EGCG와 ECG는 증가하였으며, Bacillus pumilus, Bacillus subtilis는 모든 카테킨류(EGC, EC, EGCG, ECG)에서 감소하였다. 위와 같은 실험의 결과에서 녹차에 천일염과 Paenibacillus spp를 함께 3일 동안 발효시킨 결과에서 가장 많은 카테킨류가 추출되었다. In an experiment in which fermentation was done by adding fungal species that have antibiosis but do not have cellulase, the extraction amount of EGC, EC, EGCG, and ECG increased in all samples that fermented by adding sun-dried salt compared to those that fermented only with green tea after fermenting green tea by mixing it with sun-dried salt. In the analysis conducted according to the days of fermentation, the high extraction amounts of EGC(epigallocatechin), ECG(epicatechin gallate), EC(epicatechin), and EGCG(epigallocatechin gallate) were detected on the second and third day. Furthermore, when fermentation was done by adding ferment bacillus, all types of catechin(EGC, EC, EGCG, ECG) extraction increased in Paenibacillus spp but in Bacillus amyloliquefaciens, EGC and EC decreased while EGCG and ECG increased; whereas in Bacillus pumilus and Bacillus subtilis all types of catechin(EGC, EC, EGCG, ECG) decreased. The results of the above experiment reveal that the largest amount of catechin was extracted from the result which conducted fermentation for three days together with sun-dried salt and Paenibacillus spp in the green tea.

Evaluation of Airborne Bacteria and Fungi in Surgical Areas at the Animal Hospital

정성수,강윤태,Yawon Hwang,유승원,장혜진,오혜종,강지훈,장동우,나기정,김근형 한국임상수의학회 2017 한국임상수의학회지 Vol.34 No.2

Studies on the concentration of airborne microorganisms in human medicine as a part of a study on the nosocomial infections have been conducted properly, but in veterinary medicine, there has been rarely performed in Korea to the best of study’s knowledge. The purpose of this study was to evaluate the distribution of airborne microorganisms and to identify their species in different places in the animal hospital to alert the necessity of thorough cleanliness management. This study evaluated the concentrations of airborne bacteria and fungi in hospital areas, such as patient waiting room, internal medicine ward, surgical ward and radiological diagnostic ward. The concentration of bacteria and fungi was significantly lower (p < 0.05) in two operating rooms and higher in the patient waiting room. The dominant species of bacteria were Micrococcus spp., Staphylococcus spp., and fungi were Penicillium spp., Dermatophyte mold. Animal hospitals need to perform proper procedures for disinfection, sterilization, and environmental cleaning as well as appropriate employee training and monitoring in order to the maximum prevention of the risk of nosocomial and surgical infections

한국 성인에서 대사증후군 및 Metabolic syndrome score와 맥압의 관련성

박선영(Park, Sun-Young),윤현(Yun, Hyun),오혜종(Oh, Hye-Jong) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.9

본 연구는 국가자료인 2012년도 국민건강영양조사 자료를 이용하여 20세 이상 성인(n=5,889)에서 대사증후군 및 Metabolic syndrom score(MSS)와 맥압(Pulse pressure, PP)의 관련성을 평가하고자 실시하였다. 연구결과에서 맥압에 대한 관련변수를 보정하였을 때, 맥압에 대한 평균값이 MSS 0은 41.30±0.34 mmHg, MSS 1은 42.16±0.31 mmHg, MSS 2는 44.73±0.34 mmHg, MSS 3은 46.46±0.42 mmHg, MSS 4는 48.62±0.58 mmHg, MSS 5는 53.50±1.05 mmHg으로 MSS가 증가 할수록 증가하였고(p<0.001), Non-Metabolic syndrome군(42.77±0.19 mmHg)에 비하여 Metabolic syndrome군(47.25±0.34 mmHg)에서 유의하게 증가하였다(p<0.001). 또한 관련변수를 보정한 후 Hyper-PP(>61 mmHg)의 Odd Ratio(OR)값은 MSS 0에 비하여 MSS 1은 4.49(95% confidence interval[CI], 2.68-7.57), MSS 2는 8.01(95% CI, 4.77-13.47), MSS 3은 11.37(95% CI, 6.67-19.35), MSS 4는 19.69(95% CI, 11.20-34.60), MSS 5는 34.07(95% CI, 17.44-66.52)로 MSS가 증가할수록 Hyper-PP 의 OR값도 증가하였고, Non-Metabolic syndrome군에 비하여 Metabolic syndrome군[2.83(95% CI, 2.29-3.49)]에서 유의하게 증가하였다. 결론적으로 대사증후군과 MSS의 증가는 맥압을 증가시킨다. The aim of this study was to assess the association of metabolic syndrome, metabolic syndrome score (MSS) and pulse pressure (PP) in Korean adults. The study subjects were Korean adults 20 years or older (n=5,889) who participated in the Korea National Health and Nutrition Examination Survey 2012. After adjusting for factors, such as year and gender and BMI, the mean PP increased with increasing MSS (MSS 0, 41.30±0.34 mmHg and MSS 1, 42.16±0.31 mmHg and MSS 2, 44.73±0.34 mmHg and MSS, 3 46.46±0.42 mmHg and MSS 4, 48.62±0.58 mmHg and MSS 5, 53.50±1.05 mmHg), and the mean PP for metabolic syndrome(47.25±0.34 mmHg) increased in comparison to Non-Metabolic syndrome (42.77±0.19 mmHg). When logistic regression analysis was performed, the odds ratio (OR) of Hyper-PP (61> PP) for MSS 0 was 4.49 in MSS 1 (95% confidence interval[CI], 2.68-7.57) and 8.01 in MSS 2 (95% CI, 4.77-13.47) and 11.37 in MSS 3 (95% CI, 6.67-19.35) and 19.69 in MSS 4 (95% CI, 11.20-34.60) and 34.07 in MSS 5 (95% CI, 17.44-66.52), metabolic syndrome was associated with an increased Hyper-PP(OR 4.6, 95% CI, 2.0-10.4). Conclusion. These results suggest that an increase in MSS or metabolic syndrome might increase the pulse pressure.