수용성 첨가제를 함유하는 에틸렌초산비닐 메트릭스로부터 5-플루오로우라실의 방출

오승열,유영미,김승수,신병철,육순홍,이해방 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.4

In our previous work. we have studied the effect of lactose and sodium alginate (SA) on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) matrix. These hydrophilic additives promoted the rate of 5-FU release and the increase in rate was larger when SA was used. Both additives showed better ability to increase the rate than 5-FU itself. In this paper, we extended our study to another hydrophilic additive, Carbopol 940 (CP). Compared to SA or lactose, CP increased the rate of 5-FU release markedly. Release rate increased as the loading amount and the pH of the release medium increased. After release experiment, matrix volume increased up to 15 times of that before release experiment. depending on the amount of CP dispersed in the matrix and the pH of the release medium. On the other hand, the volume of the matrix containing lactose or SA decreased, The weight changes of the dry matrix before and after release experiment imply that CP is not released out of the matrix, to the contrary of lactose and SA. Scanning electron microscope study clearly showed that large cavities and pores are generated on the surface and the inside of the matrix. These results indicate that the mechanism by which CP increases the release rate is quite different from that of monomeric additives such as lactose or SA.

듀얼 영 벡터 모드를 갖는 2상 RCD-PWM기법에 의한 유도 모터의 스위칭 소음저감

오승열,위석오,정영국 전력전자학회 2004 전력전자학회 논문지 Vol.9 No.6

In this paper, a two-phase DZRCD(Dual Zero Vector Modes RCD) technique is proposed to develope the problem of a conventional two-phase RCD-PWM (Random Centered Distribution PWM) which gives the power spectra of narrow band range in the high modulation index (M). In the proposed DZRCD technique, the zero vector V0 is selected as V0(111) for M 0.8. Also, V0 is selected as V0(000) for the modulation indices < 0.8. For the implementation of the proposed method, a 16-bit micro-controller C167 was used and the experiments were conducted with the 1.5kw induction motor under no load condition. The experimental results show that the voltage / current spectra is spread to a wide band range, and the switching noise of motor is reduced by the proposed method compared to the conventional random operation. 본 연구에서는 높은 변조지수 M 영역에서는 소음 및 고조파 스펙트럼의 광대역화 효과가 저하되는 2상 RCD-PWM(Random Centered Distribution PWM)기법의 문제점을 개선하고자, 듀얼 영 벡터 모드를 갖는 2상 RCD(Dual Zero Vector Modes RCD : DZRCD)기법을 제안하였다. 제안된 2상 DZRCD기법은 변조지수 M=0.8을 기준으로 하여 M이 0.8보다 큰 영역에서는 영 벡터로 V0(111)를 선택하고, 0.8보다 작은 영역에서는 V0(000)를 선택한다. 제안된 방법을 16비트 마이크로 콘트롤러인 C-167기반의 유도 모터 구동 시스템에 적용해 본 결과, M이 0.8이상인 영역에서 모터의 전압 / 전류 및 스위칭 소음 스펙트럼의 광대역화 특성이 종전의 방법과 비하여 우수함을 확인할 수 있었다.

수원 오목천동 유적 -화성 농진청 종전부동산 5지구(3지점) 내 유적-

오승열,장종빈 중부고고학회 2020 중부고고학회 학술대회논문집 Vol.2020 No.2

이온토포레시스를 이용한 Celecoxib 전구약물의 피부투과

오승열 숙명여자대학교 경제연구소 2010 論文集 Vol.25 No.-

적조발생과 기상요소의 상관관계 연구

오승열,윤홍주 해양환경안전학회 2015 해양환경안전학회 학술발표대회 논문집 Vol.2015 No.04

경피약물전달

오승열 한국피부장벽학회 2006 한국피부장벽학회지 Vol.8 No.1

핵폐기물 이전문제와 동북아 국제질서

오승열 북한연구소 1997 北韓 Vol.- No.303

해양기후변화에 의한 한국주변 해역에서 멸치와 꽁치의 어장 변화 연구

오승열,장선웅,윤홍주,Oh, Seung-Yeol,Jang, Sun-Woong,Yoon, Hong-Joo 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.3

본 연구는 한국 주변 해역을 중심으로 해양기후변화에 따른 어획량 변동을 연구하는데 목적을 두었다. 조사 대상 지역은 북위 $31^{\circ}{\sim}38^{\circ}$, 동경 $124^{\circ}{\sim}132^{\circ}$의 한반도 주변해역이며 사용한 자료는 국립수산과학원의 수온, 염분, 용존산소의 2000~2009년까지의 자료와 위성자료를 각각 사용하였다. GIS를 활용하여 공간변동특성을 분석하였다. 연구기간동안 남해의 경우 수온은 평균 $1.45^{\circ}C$ 상승하였고, 동해의 경우는 평균 $0.83^{\circ}C$ 상승한 것으로 나타났다. 수온상승과 멸치 및 꽁치의 어획량을 비교하여 보면 멸치는 7~9월과 12~3월 사이에 많은 양이 어획되며 4~6월에는 상대적으로 어획양이 적었다. 연별로는 2000년 이후 멸치의 어획량이 상승하였다. 꽁치는 5월과 6월에 가장 많은 양이 어획되며 8월과 9월에는 극소량이 어획되는 것으로 나타났다. 결과적으로 수온 상승으로 인하여 난류성인 멸치의 어획량은 증가하고 한류성인 꽁치는 어획량이 점차 감소하였다. The variations of catch of anchovy and saury due to oceanic climate change in the Korean Seas were studied. This study area was $31^{\circ}{\sim}38^{\circ}$ N and $124^{\circ}{\sim}132^{\circ}$ E. And data (seawater temperature, salinity, dissolved oxygen) is used from NFRDI (National Fisheries Research and Development Institute) and SST (Sea Surface temperature) obtained to satellite images (NOAA/AVHRR) during 2000 to 2009. The spatial characteristics are analyzed by GIS (Geographic Information System). The results showed that the average of seawater temperature in the depth of 20m increased $1.45^{\circ}C$ in the South Sea and $0.83^{\circ}C$ in the East Sea, respectively. The maximal catch of anchovy was highest in summer (July~September) and winter (December~March), respectively, in compared with spring (April~June). Catch of anchovy has increased since 2000. The maximal catch of saury was highest in spring (May~June), in compared with spring (August~September). The increment of seawater temperature contributed to increase the catch of anchovy, but catch of saury was decrease in the same times.

The Effect of Oleic Acid and Propylene Glycol on the Electrical Properties of Skin

오승열,Oh, Seaung-Youl,Guy, Richard H. 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4

The effects of oleic acid, propylene glycol and 5% (w/w) oleic acid in propylene glycol on the electrical properties of hairless mouse skin were studied and the results were compared. The complex electrical impedance was measured as a function of frequency, and resistance and capacitance were determined from the Nyquist plot. Immediately after the treatment with oleic acid, resistance was 145% of the pretreatment value. However it decreased with time and, after 20 hours, it was about 25% of its pretreatment value. Capacitance increased; immediately after the treatment, it was about 125% of pretreatment value and it seemed to increase slowly with time. When the skin was treated with propylene glycol, resistance decreased about 5O% and capacitance increased about 65%. Similar results were observed when the skin was treated with 5% (w/w) oleic acid in propylene glycol, except that the magnitude of resistance drop was much larger. Oleic acid acted synergistically with propylene glycol. Together with the flux data in the literature, the results obtained in this work indicate that electrical resistance is closely related to the permeability of drug molecules through the skin. The results are discussed in terms of the mechanism of action of these penetration enhancers. Overall, this work provided further mechanistic insight into the role of SC lipids in skin resistance and capacitance.

이온토포레시스를 이용한 프로스타글란딘 E1의 경피흡수

오승열,신동숙 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.2

We have studied the transdermal flux of prostaglandin E₁(PGE₁) from a hydrogel patch through hairless mouse skin, to test the possibility of developing a transdermal delivery system. Karaya gum patch containing PGE₁, was prepared by casting method. PGE₁ was stable in the patch for 10 weeks. The effect of current application, enhancer (propylene glycol monolaurate : PGML), adhesive and patch thickness on the flux was studied using side-by-side diffusion cell. Passive flux of PGE₁ was negligible. Cathodal delivery increased the flux about 20 fold. As the concentrations of PGML increased, flux increased. When 5% PGML was used as the enhancer, maximum flux by cathodal iontophoresis was 55 ㎍/㎠·hr. It increased about 2 folds to 100 ㎍/㎠·hr, when the amount of PGML used was 9%. Large increase in flux and the decrease in time to reach maximum flux were observed when the skin was pretreated with neat PGML (maximum flux obtained was about 200 ㎍/㎠·hr). Use of adhesive decreased the flux significantly. To the contrary of our expectation, increase in current density decreased the flux. These flux data together with the stability data indicate that, though the onset of sufficient delivery occur after 1-2 hours of application, therapeutic amount of PGE₁ can be delivered through skin using iontophoresis and penetration enhancer.