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RISS 인기검색어
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- 저자 : 오상유 ( Sang Yu Oh ) (검색결과 4 건)
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천식 의심 환자에서 기관지 확장제 반응 및 만니톨 기도과민성과 호기산화질소의 연관성
오상유 ( Sang-yu Oh ),이민형 ( Min-hyung Lee ),오다은 ( Da-eun Oh ),최길순 ( Gil-soon Choi ),김석현 ( Seok-hyeon Kim ),박영찬 ( Young-chan Park ),김희규 ( Hee-kyoo Kim ) 대한내과학회 2017 대한내과학회지 Vol.92 No.5
Background/Aims: Exhaled nitric oxide (NO) has been extensively investigated as a marker of airway inflammation in asthma, and fractional exhaled nitric oxide (FeNO) is recognized as a useful tool for its evaluation. The aim of this study was to investigate the relationships between FeNO levels and bronchodilator response (BDR), and between FeNO and mannitol-induced airway hyperresponsiveness (AHR), in patients with suspected asthma. Methods: Clinical variables were collected from patients aged ≥ 13 years with suspected bronchial asthma and measured levels of FeNO. These levels were compared with patient values for forced expiratory volume in the first second (FEV1) and forced expiratory flow at 25 and 75% of the pulmonary volume (FEF<sub>25-75%</sub>) in bronchodilator response tests under control conditions, and during bronchial provocation with mannitol. Correlations and receiver operating characteristic (ROC) curves between FeNO levels and each test were assessed. Results: A total of 259 patients were included in the analysis. The mean ages of the two test groups were 41.1 and 47.8 years, respectively. FeNO levels were strongly correlated with bronchodilator response (%) and with the mannitol dose producing a 15% fall in FEV1 (PD15). On the other hand, FeNO levels were only weakly correlated with FEF<sub>25-75%.</sub> The optimal cut-off values for FeNO to predict a positive BDR and AHR were 38.5 and 29.5 parts per billion, respectively. Conclusions: This study suggests that FEV1 and FEF<sub>25-75%</sub> airway responses correlate with FeNO levels in patients with suspected bronchial asthma. FeNO levels may help to predict positive responses to BDR and AHR. (Korean J Med 2017;92:458-466)
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폐내압증가시(肺內壓增加時)의 동맥혈압(動脈血壓) 및 심박변동(心搏變動)에 관(關)하여
김규수(Kim, Kyu-Soo),오상유(Oh, Sang-Yu),최병옥(Choi, Byung-Ok),이중길(Lee, Joong-Kil) 대한생리학회 1969 대한생리학회지 Vol.3 No.2
Effects of graded increase of positive lung inflation upon heart rates and arterial blood pressure were observed in the anesthetized dogs to analyze the mechanical and neural regulatory factor in response to the positive inflation of the lung. The results obtained were summarized as followings: 1) When the low grade of positive lung inflation was employed under the mild to moderate anesthesia, central venous pressure was linearly increased while heart rate was decreased. After bilateral vagotomy, central venous pressure was obviously increased while heart rate was constant. 2) When the high degree of positive lung inflation was employed, changes of central venous pressure and heart rate were not significant. 3) The low grade of intrapulmonary pressure increase caused reflex tachycardia in phase 2 and overshooting in phase 4 in response to the systemic arterial blood pressure change. 4) On the other hand, the high degree of intrapulmonary pressure increase caused paradoxical bradycardia in phase 2 and lack of overshooting in phase 4 in response to the systemic arterial blood pressure change. 5) It may be noted that the experimental model employed in the present study is a useful tool to evaluate and analyze the neural and mechanical regulatory factor in response to the graded increase of the positive lung inflation.
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만성 살리실산염 중독에 의한 가성 고염소혈증 및 대사장애
김효종 ( Hyo Jong Kim ),오유정 ( You Jeong Oh ),이정석 ( Jeong Seok Lee ),오상유 ( Sang Yu Oh ),이종윤 ( Jong Yoon Lee ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4
Despite the increasing use of alternative analgesic agents, salicylate overdose remains a not-uncommon problem. Severe poisoning is life threatening, so prompt treatment and supportive measures are required to reduce mortality. Generally, salicylate intoxication results in the development of high-anion-gap metabolic acidosis. However, outside of Korea, normal-anion-gap or negative-anion-gap metabolic acidosis with hyperchloremia is rarely reported. We report herein the case of an 83-year-old female patient with chronic aspirin intake who presented with hyperchloremia and a negative anion gap. The patient’s symptoms improved with conservative treatment and hemodialysis; notably, her chloride levels decreased as her blood salicylate concentrations decreased. Salicylate may cause hyperchloremia, demonstrating the importance of careful documentation of patient medication histories. (Korean J Med 2015;89:457-460)
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一酸化炭素中毒 家兎의 肝, 腎組織 및 赤血球의 酸素 消費量에 대하여
申基棟,李圭源,吳相由,李東一,申鉉鑽 최신의학사 1972 最新醫學 Vol.15 No.2
In an attempt to observe a possible effect of CO intoxication on the oxygen consumption rates (Q02) of liver, kidney and red blood cell, the rabbit was exposed to either 0.2% CO gas for six hours or 0.1 CO gas for two hours daily for five days. The Q02 of the liver, kidney and red blood cell was measured by the Warburg's standard manometric method, and a comparison was made with the control. The results obtained are summarized as follows: 1. The Q02 of the liver, kidney and red blood cell in the normal rabbit was 1.82±0.3111 02/hr. /mg. D. W., 4.67±0.57 pl 02/hr. /mg. D. W. and 4.40 ? 10'9 pl 02/hr. /RBC, respectively. 2. In the group where the rabbit was exposed to 0.1% CO gas for two hours daily for five days, the QO2 of the liver, kidney and red blood cell was 1.41±0.24, 4.62±0.54 and 4.12.10-9, respectively. 3. The QOz of the liver, kidney and red blood cell in the 0.2% CO exposed group was 1. 75±0. 24, 4.70±0.72 and 4.10. 10'9; respectively. 4. From the above, it may be concluded that CO gas as used in this study do not produce a significant change in Q02 of the some organs from the control.
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