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일회통과 관류실험시 물의 수송: 관류액의 종류와 삼투압의 영향
이정화(Jeong Hwa Lee),이현주(Hyun Joo Lee),용철순(Chul Soon Yong),오두만(Doo Man Oh) 대한약학회 1995 약학회지 Vol.39 No.4
The single-pass perfusion experiments were performed in anesthetized rats to investigate the effects of perfusates and their osmolality on the water transport and to determine the correlation between the extent of water transport and the volume change of perfusate. Phenol red was used as a nonabsorbable marker. In normal rats, when perfused at a flow rate of 0.5ml/min, 2-(N-morpholino) ethanesulfonic acid (MES) and Sorensen''s phosphate buffers showed minimal net water transport as 0.125 and 0.173%/cm of intestinal length, respectively. Hypotonic perfusate of 200mOsm/kg of water and hypertonic perfusate of 400mOsm/kg of water generated significant water transport compared with isotonic perfusate of 300mOsm/kg of water. There was a linear correlation between the extent of water transport and the volume change of perfusate, suggesting that the volume change can be used as a measure of water transport.
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정현정,용철순,최윤수,오두만 ( Hyun Jeong Jeong,Chul Soon Yong,Yoon Soo Choi,Doo Man Oh ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A Amino-β-lactam antibiotics are absorbed by the dipeptide transporter in the small intestine. These uptakes are coupled to a proton influx. The inward proton gradient is partly induced by the Na^+/H^+ exchanger and calcium ion is involved in control of this antiport. Interaction between ampicillin which is one of the amino-β-lactam antibiotics and nifedipine which is one of calcium channel blocking agents was studied in rats in vivo and with rabbit jejunum mounted on the Sweetana/Grass diffusion cells in vitro. Bioavailability of ampicillin was increased significantly when nifedipine was co-administered orally in rats. There were no differences in the distribution phase and the elimination phase when ampicillin was given either alone or with nifedipine intravenously. Conditions for in vitro experiments were determined. The lift rate of O₂/CO₂ gas was controlled to 3 bubbles/sec and ampicillin was stable in the Kreb`s buffer at pH 6.0. Absorption of ampicillin was the greatest when the completely-stripped serosal membrane was used. Transport of ampicillin from mucosal to serosal side in the rabbit jejunum was enhanced by 32% in the presence of nifedipine (p=0.059). Above results suggest that nifedipine might increase the plasma level of ampicillin via the improved absorption in the intestine rather than the reduction in the elimination or/and alteration in the distribution.
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정현정,용철순,최윤수,오두만 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-
Amino-β-lactam antibiotics are absorbed by the dipeptide transporter in the small intestine. These uptakes are coupled to a proton influx. The inward proton gradient is partly induced by the Na^(+)/H^(+) exchanger and cakium ion is involved in control of this antiport. Interaction between ampicillin which is one of the amino-β-lactam antibiotics and nifedipine which is one of calcium channel blocking agents was studied in rats in vivo and with rabbit jejunum mounted on the Sweetana/Grass diffusion cells in vitro. Bioavailability of ampicillin was increased significantly when nifedipine was co-administered orally in rats. There were no differences in the distribution phase and the elimination phase when ampicillin was given either alone or with nifedipine intravenously. Conditions for in vitro experiments were determined. The lift rate of O₂/CO₂ gas was controlled to 3 bubbles/sec and ampicillin was stable in the Kreb's buffer at pH6.0 Absorption of ampicillin was the greatest when the completely-stripped serosal membrane was used. Transport of ampicillin from mucosal to serosal side in the rabbit jejunum was enhanced by 32% in the presence of nifedipine (p=0.059). Above results suggest that nifedipine might increase the plasma level of ampicillin via the improved absorption in the intestine rather than the reduction in the elimination or/and alteration in the distribution.
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흰쥐의 소장에서 음식물이 암피실린의 흡수에 미치는 영향
오두만,이현주,이정화,권용준,양재하 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4
The purpose of this study is to verify the interaction between food and ampicillin which is one of the aminopenicillins known to be absorbed by a specified dipeptide transporter in the small intestine. The absorption of ampicillin was measured in the presence of the high carbohydrate food, high fat food, and high protein food, and compared with that in the presence of the control normal food. In situ single-pass perfusion method was chosen in these experiments using two jejunal segments in the rat. Reduction in the absorption of ampicillin was not shown, when both high carbohydrate food and high fat food were co-perfused with ampicillin. When the high protein food was co-perfused with ampicillin, the difference of C_(out)/C_(in) of ampicillin ratio was 0.084 ± 0.082. showing a trend of reduced absorption without a significance. Further, glyclysarcosine (Gly-Sar) which is a stable dipeptide in the small intestine was used in order to see the direct competitive inhibition with ampicillin on the dipeptide transporter. The difference of C_(out)/C_(in) ratio was 0.078 ± 0.020 in the presence of 10 mM Gly-Sar, showing a significant inhibition of ampicillin absorption (p<0.02). It suggests that dietary di- and tripeptides, the digestive products of protein food, might have influence on the absorption of ampicilln, and that ampicillin could be given at the fasting state for better absorption.
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일회통과 관류실험시 물의 수송 : 관류액의 종류와 삼투압의 영향 Effects of Some Perfusates and Their Osmolality
이정화,이현주,용철순,오두만 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The single pass perfusion experiments were performed in anesthetized rata to investigate the effects of perfusates and their osmolality on the water transport and to determine the correlation between the extent of water transport and the volume change of perfusate. Phenol red was used as a nonabsorbable marker. In normal rats, when perfused at a flow rate of 0.5 ml/min 2-(N-morpholino) ethanesulfonic acid (MES) aid Sorensen's phosphate hullers showed minimal net water transport as 0.125 and 0.173 %/cm of intestinal length, respecetively. Hypotonic perfusate of 200 mOsm㎏ of water and hypertonic perfusate of 400 mOsm/㎏ of water generated significant water transport compared with isotonic perfusate of 300 mOsn/㎏ of water. There was a linear correlation between the attent of water transport and the volume change of perfusate, suggesting that the volume change can be used as a measure of water transport.
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