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실험적 뇌혈관연축에 대한 Nimodipine의 효과 : 전자현미경학적 고찰 Electron Microscopic Studies
심상일,신규만 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.8-9
In order to evaluate the effect on nimodipine on the cerebral vasospasm, twelve adult mongrel dogs were stuided in this experiment. This animals were divided into 2 groups ; Intracisternal injection of autogenous blood(Group Ⅰ : no treatment group) and intravenous nimodipine administration after intracisternal injection of autogenous blood(Group Ⅱ : treatment group). Nimodipine was administered 12 hours after intracisternal injection of autogenous blood for 7 days. Dogs were sacrificed at 8th day after intracisternal injection of autogenous blood and the ultrastructual changes were studied. The results were as follows : In Group Ⅰ basilar artery showed endothelial cell swelling with distruption of intercellular junction, subendothelial edema and thickening of the internal elastic lamina with marked edematous change. The pathologic changes of arteries in Group Ⅱ were considered more favorable than that of Group Ⅰ. These results suggest that early intravenous treatment with nimodipine is benifical in the treatment of vasospasm of this models.
심상일,김성학,박동빈,신규만 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.6
From January 1987 to December 1989, Six patients with lipomyelomeningocele were operated. There were 4 females and 2 males. The chief complaints that caused these patients to seek help were cosmetic effect of the mass on back, urinary incontinence, ankle deformity and weak leg. The postoperative results were as follows : Patient treated before developing neurological deficit remained unchanged neurologically. Patient treated after developing neurological deficit were left with neurological sequelae. lipomyelomeningoceles are serious lesion which recommand early prophylactic surgery.
심상도 문화관광연구학회 2002 문화관광연구 Vol.4 No.2
This study attempts to find appropriate and effective measures to establish tourism information center which reflect the trends of the tourism environment, and to improve tourism information services for domestic and overseas tourists. Yangsan is rich in tradition, historical sites, natural attractions, and cultural treasures, such as the Tongdosa Temple, one of the three largest Buddhist temples in Korea, a pile of shells from the Iron Age, ancient tombs dating back to the Shilla Dynasty, the Naewonsa Temple, the traditional Gaya dynasty festival, and Mt. Yeongchuk. The competitiveness of the factories located in Yangsan city industrial complex. Established on February, 2001, "Yangsan Tourist Information Center" serves as a nest for every one in Yangsan as well as a treasure trove of information about the city, with history and traditional charms. Tourist Information Center has amassed a variety of resources about Yangsan.
란크릭 캅셀(플루옥세틴 20mg)에 대한 프로작 캅셀의 생물학적 동등성 시험
심상범,조요나,오한석,류재환,이경태,김남재,서성훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-
Bioequivalence of two flouxetine capsule, ProzacR (Lilly kora Ltd.) and LanclicR (Samsung Pharm. IND. Co.), was evalated according to the guideline of KFDA. Twenty four healthy male volunteers (21-26 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After 60mg of fluoxetine was orally administered, blood was taken at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 32, 48 and 72 hours after administration and just before administration. Plasma was analyzed for fluoxetine and internal standard (clomipramine) by a sensitive and validated HPLC assay. The pharmaco kinetic parameters (AUCt, Cmax and Tmax) wre calculated and ANOVA test was used for the statistical analysis of parameters. Differences in (AUCt, Cmax and Tmax between two capsules were -0.90, 3.46 and -14.08% respectively. All powers (1-β) for AUGt, Cmax and Tmax were more than 0.9. Detectable differences (Δ) and confidence interval were all less than ±20%. All the parameters above met the criteria of KFDA for bioequivalence and indicated that LanclicR capsules are bioequivalent to ProzacR capsules.