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항균제 내성 대장균의 생태적 분포 Ⅲ. : Rifampicin, nalidixic acid, oxolinic acid와 sulfa 제제에 관하여
이광호,차창룡,국윤호,최명식,김익상,장우현,이승훈,신정식 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1
We studied the differences in the MIC distribution of E. coli isolates, from a doctorless remote arwqwang Won. Do province+WD), a leprosarium (So Rock Do=SRD) and Seoul National University Gospital (SNUH> against rifampicin. nalidixic acid, oxolinic acid &a sulfa drags including co-trinoxawle. . So the widespread and prolonged- use of antimicrobial agents is presumed to facilitate the increase of drng-resistapt strains among the normal flora of the residents in a comunity that .the isolates from SNUH- were further divided into two groups, SNUH in-patient (IP) and SNUH out-patient(OP) and the isolates f p m SRD into DDS (isolates. from.leprosy patients.who are taking DDS only) and R f (isolates from leprosy patients who are taking rifampicin-.and DQS) grougs. Nnmber of, E. coli isolates studied were 93 st;ains from SNUH patients (SNUH-IP, 46; SNUF-OP, 43, 150 strains from SRD patients (SRD-DDS, 102; SRD-Rf,' 48) and 119 strains from 'KWD residents. DisLribntion of E. mli- strains a.mording to thir respective MTC's shows that E. coli possesses not only an intrinsic component in resistance (or susceptibility) to the drugs (rif-ampicin, 2-32 pg/ml; nafii%Xic a,cid, 1-16 pg/d; oxolinic acid, * 0.13-2 pg/ml; DDS, 32-1024 pg/ml; sulfadiazine, 2-256 pg/d, sulfamera&& 4-256 pg/ml; sulfadimethoxine, .16~1024 pg/ml; sdfamonornethoxine, ~-12~,pg&d; sulfamethoxazde, 2-128 pg/m&. trimetk0p-Irim, 0.06-2 pg/fnl; co-trimoxwole, 0,. 25-4 pg/ml) but also distinct MIC values of acquired resistance quite different from the intrinsic ones. The .carriage rate of rifampicin resistant strains in the SRD-Rf patients was the higheest among the study:groups while t m e , of SNUH patients and of the KWD residents were equally negligible, as expectediy. Drug-resistant E. coli strains against nalidixic acid and oxolinic acid were uncommon i n the SNUH, SRD and KWD isolates. However, resistance to sulfa drugs were prevalent in the SNUH, SRD and KWD isolates in the decreasing order. Taken together, these results strongly suggest that drug resistznce in Korea is a localized problem in some community under a high selection pressure of antimicrobial agents rather than a nation-wide one. Trimethoprim resistance gave rise to the high-level resistance 'to co-trimoxazde while the sulfamethoxazole resistance t o the low level resistance against the co-trimoxazole.