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호흡기 상피세포에서 Vasoactive Intestinal Peptide에 의한 MUC2/5AC 생성
김용대,장근영,신재흔,곽동석,이형중,송시연,송계원 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.7
Background and Objectives:Vasointestinal peptide (VIP) is an important neurotransmitter involved in the regulation of mucus n MUC2/5AC genes expresion and mucin secretion in human airway epithelial cells. Materials and Method:The mRNA levels of MUC2/5AC genes and mucin secretion were determined by RT-PCR and the imunoblot method in cultured human airway NCI-H292 epithelial cells. Results:VIP (10-6- 10-10 M) induced MUC2/5AC gene expression and mucin secretion in a reverse MUC2/5AC was 10-10 M of VIP. Acti-nomycin D inhibited the VIP-mediated MUC2/5AC gene expression and mucin secretion, but cycloheximide did not. Budesonide attenuated the VIP-mediated MUC2/5AC genes expression and mucin secretion. RU-486, a glucocorticoid receptor antagonist, restored the inhibitory efect of budesonide. Conclusion:These results sugest that VIP regulates MUC2/5AC gene expression MUC2/5AC genes expression and mucin secretion through the glucocorticoid receptor.
김용대,곽동석,이형중,신재흔,배창훈,송시연 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.1
Sinonasal Undifferentiated Carcinoma (SNUC) is a very rare, highly aggressive malignant tumor of the nasal cavity and paranasal sinuses. SNUC tends to present with advanced-stage disease, often with intracranial invasion. It requires an aggressive multimodality therapy that includes surgical resection. A cure rate of less than 20% is generally reported in the literature, with most patients dying within 1 year of onset of the disease. Three patients diagnosed as SNUC were treated at the Yeungnam University Medical Center between the years 2000 and 2003 were analyzed retrospectively. All patients presented with the disease very advanced. The three cases were given chemotherapy or chemotherapy with radiotherapy. Two patients died of the disease, surviving only 6 and 11 months following treatment, respectively. We did a follow-up on just the one remaining case with incomplete controlled disease for 27 months. The overall prognosis of SNUC is very poor. We consider that more intensive multimodality therapies are recommended for all patients with SNUC.
호흡기 상피세포에서 IL-1b에 의해 유발되는 MUC2/MUC5AC 유전자 발현 및 점액분비에 있어서 Budesonide의 억제작용
김용대,조중석,장근영,신재흔,송시연,윤석근 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.9
Background and Objectives:Mucus hypersecretion is a hallmark of many respiratory inflammatory diseases such as asthma, bronchitis and sinusitis. While the current therapeutic pharmacological approaches to reducing mucus hypersecretion are limited, clinical studies have suggested that glucocorticoids reduce mucus secretion in patients with airway disease. However, the effect of glucocorticoids on mucus hypersecretion is not clear. Recently, we observed that IL-1β induces MUC2 gene expression and mucin secretion in a previous experiment. This study was designed to investigate the effects of budesonide on the IL-1β-mediated MUC2/5AC genes expression and mucin secretion. Materials and Method:We observed the steady state mRNA level of MUC2/5AC genes using RT-PCR and mucin protein using immunoassay method in cultured human airway NCI-H292 epithelial cells. Results:Budesonide attenuated IL-1β-mediated MUC2/5AC gene expression as well as mucin secretion. The attenuated effect of budesonide was in a dose-dependent pattern. This attenuated effect of budesonide was blocked by glucocorticoid receptor antagonist, RU-486. Conclusion:This result suggests that budesonide suppresses the IL-1β-mediated MUC2/5AC genes expression and mucin secretion via blockage of glucocorticoid receptor. (Korean J Otolaryngol 2002;45:873-7)