Effectiveness and Safety of Hwangchil–Unripe Bokbunja Extract Mixture on Blood Pressure: A Randomized Double-Blind Placebo-Controlled Clinical Trial

신뢰,곽시라,주종천,하기찬,박유경,김선오,박수정 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.3

From 25% to 50% of adults are affected by prehypertension. Prehypertension increases the risk of hypertension and affects the heart and systemic vascular system. Food mixed tree essence of Dendropanax morbifera called Hwangchil in Korean and immature fruit of Rubus coreanus, called Bokbunja (HDR-2), have been studied for safety and effectiveness against prehypertension studies. This study was a randomized double-blind placebo-controlled multicenter clinical trial lasting 19 months from October 2017 to May 2019. The 88 subjects who enrolled in the study were divided into two groups. The treatment group was provided HDR-2 and the other group took a placebo. Both HDR-2 and placebo were in the form of capsules, and the dose was 900 mg per day. Subjects took HDR-2 or placebo capsules once a day for 8 weeks before dinner. The primary observational indicators were systolic blood pressure (SBP) and diastolic blood pressure (DBP), and the secondary observational indicators were mean arterial pressure (MAP), mean pulse pressure, pulse rate, angiotensin-converting enzyme activity, renin activity, aldosterone, and highly sensitive-C reactive protein. The number of measurements was three times: the first visit in the screening week, the second visit in 4 weeks, and the third visit was after 8 weeks. Significant study results showed that the SBP and MAP of the HDR-2 group after 8 weeks were lower than those of the placebo group. Adverse events were not significantly different between the two groups. In conclusion, these results suggest that HDR-2 may be a useful intervention for the management of prehypertension. The protocol was registered in the Korean Clinical Trial Registration system (http://cris.nih.go.kr; registration number: KCT0004300).

제4회 ‘우리동네 캐릭터 축제 피날레’ 참가기

미디어신뢰증진팀 시청자미디어재단 2021 팩트체크 동향리포트 'FACT(팩트)' Vol.- No.2

딥페이크를 이용한 허위정보의 위험과 대응 마련의 필요성

시청자미디어재단 미디어신뢰증진팀 시청자미디어재단 2021 팩트체크 동향리포트 'FACT(팩트)' Vol.- No.2

국내 데이터베이스 검색을 통한 암성통증의 약침치료 임상연구 동향

오승윤,신뢰,주종천,박수정,Oh, Seung-Yun,Shen, Lei,Joo, Jong-Cheon,Park, Soo-Jung 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.2

Objectives: The effectiveness of acupuncture on cancer pain is relatively well established, while there have been few clinical studies on pharmacopuncture on that. This research was aimed to investigate a trend of pharmacopuncture treatment for cancer pain and to propose information for further research. Methods: Clinical studies on pharmacopuncture for cancer pain were collected from 5 Korean medical databases. And the studies were analyzed by classifications of cancer, chief complaints, interventions, treating skills, additional treatments, treatment session, outcome measures, results and adverse effects. Results: The literatures were 8 case reports and 1 randomized controlled trial. Interventions were pharmacopunctures of soyeom, mountain ginseng, Harpagophyti Radix, snake venom, Trionycis Carapax, bee venom, Aconitum Ciliare Decaisne. Treatment skills, procedures, and indications of each pharmacopuncture were different. An adverse effects of bruising, bleeding, mild chilling, sore throat and pain were mentioned on snake venom and bee venom treatment. Conclusions: An appropriate interventions and treatment skills should be selected according to the type of cancer pain. And treatment procedures to ensure safety must be developed.

비알코올성지방간의 유관 인자 임상 연구: 종양표지자, 심박변이도, 사상체질

곽시라,신뢰,박수정,권영미,주종천 사상체질의학회 2019 사상체질의학회지 Vol.31 No.2

Objectives The aim of this study is to investigate the related factors of nonalcoholic fatty liver disease (NAFLD). Methods The subjects were 187 persons diagnosed as fatty liver by abdominal ultrasonography. They were divided into three groups according to the severity of fatty liver: control, mild, moderate or severe. The three groups' general characteristics, laboratory results, liver function indexes, metabolic syndrome indexes, tumor markers, heart rate variability values and Sasang constitution distribution were compared and analyzed. Results Male ratio, height, weight, body mass index, red blood cell count, hemoglobin level and creatinine level were higher in NAFLD groups than in control group. The levels of sodium and amylase were higher in control than in NAFLD. In liver function, the levels of aspartate transaminase, alanine transaminase and gamma-glutamyl transpepsidase of NAFLD were higher. In metabolic syndrome index, systolic blood pressure, diastolic blood pressure, waist circumference, total cholesterol, triglyceride and low density lipoprotein cholesterol levels were higher in NAFLD, while high density lipoprotein cholesterol level was higher in control. The alpha-feto protein level was higher in NAFLD, and the heart rate variability was not different between NAFLD and control groups. In Sasang constitution, Taeeumin ratio of NAFLD was higher than of control. Conclusions The results suggest that nonalcoholic fatty liver is clinically related to liver dysfunction, metabolic syndrome, tumor markers, and Sasang constitution. Further studies are needed to control nonalcoholic fatty liver disease and prevent severe disease such as cirrhosis and cancer caused by fatty liver.

옻나무-두충추출혼합물(ILF-RE)의 간기능 개선에 대한 유효성 및안전성을 평가하기 위한 무작위배정 이중눈가림 인체적용시험

윤영,백향임,진희연,정다영,신뢰,주종천,박수정 대한본초학회 2020 大韓本草學會誌 Vol.35 No.1

Objectives:The purpose of this study is to determine whether Rhus verniciflua Stokes with Latin name Lacca Sinica Exsiccata, and Eucommia ulmoides Oliver with Latin name Eucommiae Cortex Extract Combination (ILF-RE) improves laboratory test results in participants with liver function disorder. Methods:This study was conducted at Woosuk university Korean medicine hospital where participants with high serum alanine transaminase (ALT) levels from 45 to 135 U/L were enrolled. Subjects received ILF-RE 3.6 g (1.2 g/day as ILF-RE) or placebo 3.6 g for 12 weeks. It was confirmed that urushiol was not detected in ILF-RE. The primary outcomes were the decrement degree of serum ALT and gamma-glutamyl transferase (GGT) levels between two groups. The secondary outcomes were the decrement degree of serum aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LD), total bilirubin, total cholesterol, triglyceride (TG) and fatty liver index (FLI) levels between two groups. Adverse events, skin prick tests, laboratory tests, and vital signs were observed and analyzed to confirm the safety of ILF-RE. Results:In the ILF-RE group, the liver function index ALT, GGT, lipid metabolism index TG, and fatty liver index FLI were significantly decreased compared to the placebo group. There was no significant difference in ILF-RE group in terms of adverse events, severe adverse events, skin prick test, laboratory test, and vital signs compared with placebo group. Conclusions:ILF-RE was found to be effective in improving liver function. In addition, no clinically significant adverse events or body changes were observed during this study.

곤곡의 극목에 대한 몇 가지 문제

오신뢰 한국공연문화학회 (구,한국고전희곡학회) 2001 공연문화연구 Vol.3 No.-

곤곡극목발미 (昆曲劇目發微)

오신뢰 한국공연문화학회 (구,한국고전희곡학회) 2001 공연문화연구 Vol.3 No.-

중국의 입지요인이 유형별 환경친화적 에너지 자원 개발에 미치는 영향

고신뢰,유염봉 한국국제상학회 2024 國際商學 Vol.39 No.1

전 세계의 지속 가능한 발전 상황과 글로벌 에너지 전환의 영향을 받아 에너지 구조에 변화가 일어난다. 중국은 '탄소 피크'와 '탄소 중립' 목표를 설정하고 새로운 에너지를 적극적으로 개발한다. 일정한 진전을 이루었지만, 이로 인해 총 전력 생산량과 시간적, 공간적 불균형이라는 모순이 커지고 있다. 따라서 에너지 개발의 입지적 요인과 전력 수요에 미치는 영향에 대한 분석이 시급하고 필요하다. 본 연구는 에너지 개발 입지가 전력 수요에 미치는 영향 요인을 분석하여 효율적인 에너지 개발 전략을 수립하는 것을 목표로 한다. 이 연구는 중국 31개 성, 시, 자치구의 에너지 개발 데이터를 활용하여 경제적, 자연적, 인문적, 정책적 요인 등의 차원을 고려한다. 회귀모델 및 VAR 모형을 사용하여 이러한 요인들이 풍력, 태양광, 수력, 화력 등 네 가지 유형의 발전원과 그리드 용량에 미치는 영향을 분석하였다. 그 결과 네 가지 발전원의 발전량 및 그리드 용량과 경제적 요인 사이에는 정의 영향이 있는 것으로 나타나 천연자원 요인과는 양의 영향이 있다. 인문적 요인의 경우 땅값은 풍력 및 태양광과 정의 영향을 미치고, 수력 및 화력과는 부의 영향이 있는 것으로 나타난다. 총인구는 수력 및 화력 발전과 약한 정의 영향을, 풍력 및 태양광 발전과 상대적으로 약한 부의 영향을 보이다. 또한 정책 요인과는 정의 영향이 존재한다. 이 연구의 기여는 이론적 관점과 실무적 관점으로 요약할 수 있다. Purpose : The purpose of this study is to analyze the influencing factors of energy development locations on electricity demand to better formulate strategies for efficient energy development. Research design, data and methodology : This research used GMM econometric model is employed to analyze the impact of these factors on the generation and grid capacity of four types of power sources: wind, solar, hydro, and thermal from 31 provinces, municipalities, and autonomous regions nationwide. Results : The results indicate a linear positive correlation between the generation and grid capacity of the four power sources and economic factors, resource factors, and policy factors. Conclusions : This paper contributes to balanced energy development policies, broadens research perspectives, enhances public understanding, and serves as a valuable reference. Its findings carry significant theoretical and practical implications for scholars, researchers, and policymakers alike.

地方应用型本科高校大学物理课程教学改革与实践

甘新磊(Xinlei Gan),彭雪峰(Xuefeng Peng),韩引霞(Yinxia Han) YIXIN 출판사 2024 教育教学研究论丛 Vol.2 No.4

针对地方应用型本科院校传统大学物理课程教学中存在的四大痛点问题,以学生的发展为中心,基于建构主义教学理论,提出了案例形象化、问题原始化等十大教学策略,并结合慕课及对分课堂各自优点,研究探索了基于“慕课+对分”的“四维度十策略”混合式教学模式。教学实践表明,这种教学模式可以有效的提升学生的学习兴趣和综合能力,课堂教学效果得到明显改进。 Aiming at the four major pain points existing in the traditional college physics teaching in local application-oriented universities, this paper puts forward ten teaching strategies, including case visualization and problem originalization, focusing on the development of students and based on the constructivism teaching theory. The research explored the mixed teaching mode of “four dimensions and ten strategies” based on “MOOCs + PAD”. The teaching practice shows that this teaching mode can effectively enhance students’ learning interest and comprehensive ability, and the classroom teaching effect has been significantly improved.