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이민화,곽효성,송영준,조용백,신광범 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.2
The study was performed to compare the dissolution, diffusion and absorption characteristics using Sartorius dissolution and absorption simulator and in vivo bioavailability of commercially available rifampicin capsules. Both brands C and F showed similar dissolution patterns and absorption properties through artificial gastric barrier in Sartorius simulator. Diffusion rate constants through the membrane of brands C and F were 3.04×40^(-3) and 2.88×10^(-3)㎝/min, respectively. Rifampicin capsules were administered orally to six fasted healthy volunteers according to cross-over design. The pharmacokinetic parameters between brands C and F, maximum plasma drug concentration (C_(max)), the time to reach C_(max), absorption rate constant and area under the curve (AUC_(0-24hr)), elimination rate constant, and amount of drug excreted in urine were 6.11 and 7.27 ㎍/㎖, 2.71 and 1.52 hr, 0.6371 and 1.6456 hr^(-1), 57.84 and 57.28㎍·hr/㎖, 0.1891 and 0.1734 hr^(-1), 119.98 and 119.93 ㎎, respectively. On the basis of experimental results, it was concluded that the bioavailability of brand C rifampicin capsules was almost the same as that of brand F rifampicin capsules.
김지현(Jihyun Kim),박염홍(Yanhong Piao),신광범(Quangfan Shen),정영철(Young-Chul Chung) 대한신경정신의학회 2018 신경정신의학 Vol.57 No.3
Successful treatment is very high in patients with first episode schizophrenia (FES). On the other hand, the problem is a frequent relapse often caused by non-compliance. The non-compliance rate in patients with FES is 40–60% within 1 year. The causes of non-compliance are diverse, such as poor insight, drug side effects, attitude of caregiver, social stigma, etc. Clinicians should be able to provide appropriate psychosocial intervention and long acting injectable antipsychotics (LAI) to overcome non-compliance. Recently, there is solid and accumulating evidence demonstrating superiority of LAI over oral medication in terms of reducing relapse or rehospitalization. In particular, a substantial portion (approximately 30–50%) of patients and caregivers prefer LAI to oral medication. Shared decision-making is the process that clinicians and patients/caregiver should go through in order to obtain the full benefits from LAI.
이민화(Min Hwa Lee),곽효성(Hyo Sung Kwak),송영준(Young Joon Song),조용백(Yong Baik Cho),신광범(Kwang Bum Shin) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
The ingredients or particle size of active substance can significantly influence the release of the drug to the gastro-intestinal fluids and thereby affect the rate and extent of absorption. Rifampicin is administered with isoniazid or pyrazinamide as combined capsules from time to time to treat for tuberculosis effectively. The influence of isoniazid and pyrazinamide and particle size of rifampicin in rifampicin combined capsules was studied on the bioavailability of rifampicin. Single oral dose of 600㎎ rifampicin as capsules was administered to volunteers in fasting conditions and we studied the diffusion, and absorption rate constant and dissolution using Sartorius absorption and dissolution simulator. Isoniazid and pyrazinamide can affect on the bioavailability of rifampicin in rifampicin combined capsules and the absorption of rifampicin has no relationship with particle size of it. Also we can predict the bioavailability of rifampicin by using the Sartorius absorption and dissolution simulator.