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손애랑,최지영,김정아,조세훈,허광화,박성희,정시련,정태천,장영동,손근종,이승호 한국생약학회 2005 생약학회지 Vol.36 No.1
develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus tri-foliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumicacid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated com-pounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse mel-anoma cell lines(IC50, 36.8M) compared with kojic acid(IC50, 150M).Key wordsPoncirus trifoliata, Rutaceae, bis(2-methylheptyl)phthalate, whitening cosmetics, melanogenesis inhibitors