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성정석,고은비,신한승 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.1
This study was conducted to evaluate the cytoprotective activity of roasted coffee residues (RCRs)extract on mouse embryonic fibroblast (MEF) cells. RCRs originated from Colombia and Honduras are relatively nontoxic to cell growth and even stimulate cell proliferation. Colombian RCRs showed most efficient protective effects on MEF cells against oxidative damage induced by H2O2compared among the extracts prepared under the same roasting time. The most significant radical scavenging activity was measured in RCR with roasting time of 8.5min. Phenolic and nonphenolic compounds in RCRs were chlorogenic acid, caffeine, caffeic acid, nicotinic acid,trigonelline, and 5-(hydroxymethyl)furfuralolehyde. Effect of Colombian RCRs on apoptosis occurred by oxidative damage was evaluated by morphological and flow cytometric analysis. Apoptotic cell accumulation was decreased by cotreatment of MEF cells with Colombian RCRs. These results suggested that antioxidant potency of RCRs suppresses the cytotoxicity which is induced by H2O2 and has a protective effect on MEF cell against oxidative stress.
Recent Advances of Biodegradable Polymers for Medical Applications
성정석,성용결 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
The recent advances of biodegradable polymers for medical applications have been reviewed on the basis of biodegradability, functionality, and biocompatibility. These include the functional biodegradable polymers synthesized in our research laboratory and some injectable biodegradable polymers developed for biomedical applications. The biodegradable polymers synthesized from Krebs cycle acid derivatives, injectable biodegradable block copolymers, biodegradable polymers for RNA interference and DNA matrix-based biopolymeric systems for tissue engineering have been also discussed briefly.
Development of Biological Functions for Polymeric Materials Utilized in Biomedical Application
성정석,Yong Kiel Sung 한국생체재료학회 2010 생체재료학회지 Vol.14 No.4
The development of biological functions for biomaterials utilized in medical application has been presented on the basis of biocompatibility and biodegradability. It has been founded that the biological functions of biomedical polymers are closely correlated to the role of cell functions in the living body. The present paper includes the biodegradable functional polymers synthesized from Krebs cycle acid derivatives and the other polymers such as biological DNA and RNA matrix systems developed for tissue engineering and biomedical applications. The biodegradable copolymer systems containing biological functions are also proposed as more useful biomaterials for biomedical application on the basis of biological adaptability.
고건,성정석,지승철,김민,장원희,강규영,김대영,이시형,신한승 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.1
Sesamol is a phenol derivative of sesame oil and a potent anti-oxidant, anti-inflammatory, anti-hepatotoxic, and anti-aging compound. We investigated the effects of sesamol on the molecular mechanisms of adipogenesis in 3T3-L1 preadipocytes. The intracellular lipid accumulation accompanied by increased extracellular release of free glycerol was decreased during differentiation on treating 3T3- L1 with sesamol. Sesamol treatment on 3T3-L1 inhibited adipogenic differentiation by down-regulating adipogenesis-related factors (C/EBPα, PPARγ, and SREBP-1). Lipid accumulation was repressed by decreasing fatty acid synthase and by up-regulating lipolysis-response genes (HSL and LPL). The molecular mechanisms of sesamol-induced inhibition in adipogenesis were mediated by increased levels of phosphorylated adenosine monophosphate-activated protein kinase and its substrate acetyl- CoA carboxylase. Sesamol treatment, in turn, modulated the different members of the mitogenactivated protein kinase family by suppressing phosphorylation of ERK 1/2 and JNK and by increasing the phosphorylation of p38. In summary, sesamol inhibits adipogenic differentiation by reducing phosphorylation levels of ERK 1/2 and JNK while inducing lipolysis by activating p38 and AMPK. Our results demonstrate that the molecular mechanisms of in vitro anti-obesity effects of sesamol are due to the combined effects of preventing both lipid accumulation and adipogenesis.
성지훈,성정석,신한승 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.6
This study was conducted to evaluate the cytoprotective activity of lotus (Nelumbo nucifera Gaertner)seed extract (LSE) on mouse embryonic fibroblast (MEF)cells. The DPPH free radical scavenging activities of LSE increased in a concentration dependent manner. The cells,damaged by oxidative stress, decreased their viability following increasing concentration of H_2O_2, but the cotreatment of ethyl acetate fraction of LSE and H_2O_2resulted in an increase in cell growth, by about 25%,compared to the cells treated with H_2O_2. The ethyl acetate fraction of LSE inhibited the cytotoxicity induced by H_2O_2in a concentration dependent manner. The treatment of the n-butanol fraction of LSE on MEF cell was also examined by analyzing the DNA content and apoptotic rate, using flow cytometry. The oxidative damage to the cells, measured by apoptotic and necrotic cell accumulation, was similar with the addition of the ethyl acetate fraction of LSE to H_2O_2. These results suggest that LSE inhibited the cytotoxicity which is induced by H_2O_2, and has a protective effect on MEF cell against oxidative stress.
Recent Trends on the Stent Research for Blood Arteries by Bibliometric Analysis
안세정,성정석,Brad Choi,Hackjoo Kim,성용길 한국생체재료학회 2014 생체재료학회지 Vol.18 No.4
The research trends on stent for blood arteries are reviewed by bibliometric analysis using 7,790 journal articles published from 1986 to 2013 of the Web of Science database. The bibliometric indicators are applied to analyze the journal article data, which are simple number of publications for selecting key players, citation indicators for measuring qualitative research performance, collaboration indicators for figuring out the degree of international collaboration and keyword mapping for identifying the research trends. The studies of stent for blood arteries are investigated on the basis of the analysis by countries, institutions and topic changing. The leading countries and institutions published many high-quality journal articles with strong international collaboration. In this report, the current status and future of research trends are clearly revealed from the periodic topic changing analysis. The keywords such as ‘drug eluting stent’, ‘stent coated with new polymers’ and ‘drug delivery systems’ have come into the recent stent-related research, which means lots of efforts are under way to overcome the present limitations of the research.
생체적합성과 생분해성을 갖는 폴리에스테르 중합체의 합성과 특성에 관한 연구(II) : Poly(1, 4-butanediol succinate)의 결정화 및 생분해성
송대경,성정석 대한의용생체공학회 1995 의공학회지 Vol.16 No.1
Biodegradable poly (I ,4-butanediol succinate) (PBS) was synthesized from 1,4-butanediol and succinic anhydride. The glass transition temperature of poly (I, 4-butanediol succinate) was revealed at $73^{\circ}C$. The crystallization and cold crystallization of the polymers were investigated as a function of holding time in melt state, cooling rate. reheating, and molecular weight. Chain scission and/or cmsslinking did not occur in the melt state at var.ious holding times. Slower scanning rate can allow more times for nucleation, rearrangement, and packing of the polymer chain, so the onset temperature of crystallization from the melt was increased. PBS crystallized from the melt was found to have spherulitic structure. The degradation behavior of PBS was studied under basic conditions and with microorganisms using the modified ASTM method. In the basic solution. PBS lost up to 85% of its mass within two days. Based upon visual observation, the crystalline structure of films composed of larger molecular weight polymers retained their crystallinity longer than similar structures in low molecular weight samples.