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경도 및 중등도 여드름 환자에서 Nadifloxacin 1% Cream 도포 후 피부 장벽 기능의 변화 및 효과에 대한 연구
설정은 ( Jung Eun Seol ),홍순권 ( Soon Kwon Hong ),서종근 ( Jong Keun Seo ),이드보라 ( Deborah Lee ),성호석 ( Ho Suk Sung ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.6
Background: Nadifloxacin is a synthetic fluoroquinolone with a broad spectrum. It has been suggested to not only have antibacterial, but also anti-inflammatory actions. In addition, it is effective against antibiotic-resistant Propionibacterium acne. Upon review of the literature, however, no studies have been performed concerning the efficacy and safety in terms of irritation potential and skin barrier changes after applying nadifloxacin. Objective: This study intended to evaluate the skin irritation and changes of the skin barrier function associated with the administration of nadifloxacin 1% cream for the treatment of acne vulgaris. Furthermore, the efficacy and safety of nadifloxacin 1% cream were also assessed. Methods: The changes in the lesion counts, Korean Acne Grading System (KAGS) and adverse events were recorded. The biophysical profiles of the skin, including transepidermal water loss (TEWL), skin surface hydration and redness were measured by Tewameter®, Corneometer® and Mexameter® for 3 weeks. Results: At the end of the therapy, 69% of inflammatory lesions (p<0.0001) and 27% of noninflammatory lesions (p=0.26) resulting from acne were decreased from the baseline. Adverse events were reported in two patients, but they were transient and tolerable. The skin barrier function showed no changes during the treatment periods. Conclusion: Nadifloxacin 1% cream is effective for the treatment of acne vulgaris without the changes of skin barrier function.
설정은 ( Jung Eun Seol ),이원경 ( Wonkyung Lee ),김도형 ( Do Hyeong Kim ),정세원 ( Se Won Jung ),성호석 ( Ho Suk Sung ),김효진 ( Hyojin Kim ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.10
Pemphigoid gestationis, also known as herpes gestationis, is a rare blistering disease associated with pregnancy, caused by autoantibody to the basement membrane component. It occurs in the second or third trimester of pregnancy or directly after delivery, as erythematous, urticarial papules, and plaques on the whole body, which aggravate to vesicles and bullae with severe pruritus. Histopathologically, subepidermal blisters and eosinophilic spongiosis are shown, and linear deposition of C3 in the dermoepidermal junction is seen on direct immunofluorescence assay. We present the case of 35-year-old woman who was diagnosed with pemphigoid gestationis, with the involvement of the uncommon site of the face.
설정은 ( Jung Eun Seol ),김효진 ( Hyojin Kim ),박인호 ( Inho Park ),서종근 ( Jong Keun Seo ),성호석 ( Hosuk Sung ),이숙경 ( Sook Kyung Lee ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.12
Proliferating trichilemmal tumor (PTT) is an uncommon neoplasm originated from the outer root sheath of a hair follicle. Malignant transformation occurs occasionally in proliferating trichilemmal tumors, which can be manifested by sudden rapid growths. Histologically, the malignant proliferating trichilemmal tumors (MPTTs) have shown severe nuclear atypia, marked cellular pleomorphism with atypical mitoses, dyskeratotic cells and infiltrating margins. Squamous cell carcinoma (SCC) should be differentiated with MPTT which indicates characteristic trichilemmal keratinization. Large tumor is considered as a risk factor of metastasis in SCC, but the relationship between tumor size and metastasis in the MPTT is not yet clarified. In this report, two patients have large erythematous nodules with focal ulceration and necrosis on their scalps and were diagnosed as MPTT. Despite the large sizes of the tumors, there were no evidences of metastases. Herein, we report 2 cases of the large MPTT which are presented without metastasis. (Korean J Dermatol 2013;51(12):983∼986)
하악전돌증환자에서 악교정수술후 저작근의 부피 및 교합력의 변화
설정은(Jung-Eun Seol),이명환(Myung-Hwan Lee),김창수(Chang-Soo Kim),홍종락(Jongrak Hong) 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.3
Purpose: The purpose of our study was to evaluate the volume of pre- and post operative masseter muscle and bite force in mandibular prognathic patients treated with SSRO with the use of the 3D CT imaging technique and occlusal force meter. Materials and methods: The study group consisted of 12 patients with mandibular prognathism (5 males and 7 females) who underwent mandibular setback surgery (BSSRO) in the Department of Oral and Maxillofacial Surgery, Samsung medical center. Bite force was measured at pre op, post op 3, 6 and 12 months by occlusal force meter(GM10, Nagano Keiki, Japan) The preoperative CT examination of subjects was performed between one month prior to operation and one year after to operation. And muscle volume was measured. Result: As compared to preoperative measurements at 1 year postoperatively the masseter & internal pterygoid muscle volume were diminished(p<0.05) The bite force steadily recovered, so at postoperatively 6 months reached the preoperative level. And at 1 year after operation, the maximum bite force was significantly greater than preoperative levels. No significant correlation was presented between masseter muscle and bite force (p>0.05), internal pterygoid muscle and bite force (p>0.05). Conclusion: In this study, the results showed that volume and bite force of the masticatory muscles decresed significantly immediate after orthognathic surgery for mandibular set-back. However, reduction of maximum bite force disappears within 6 months after surgery.
화농성 땀샘염에서 경구 항생제와 경구 레티노이드의 치료 효과에 대한 비교
설정은 ( Jung Eun Seol ),박소희 ( So Hee Park ),정소영 ( So Young Jung ),황성환 ( Sung Hwan Hwang ),왕한영 ( Han Young Wang ),김효진 ( Hyojin Kim ),서종근 ( Jong Keun Seo ),박인호 ( In Ho Park ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.10
Background: Hidradenitis suppurativa is a chronic inflammatory skin disease showing recurrent painful nodules and abscesses. Many treatment modalities, such as topical antibiotics, systemic antibiotics, retinoids, immunomodulators, biologics, and surgical treatment are used to treat the disease, but there is no single effective treatment for hidradenitis suppurativa. Objective: We conducted this study to compare the clinical outcomes of treatment with systemic antibiotics and systemic retinoids. Methods: We analyzed the clinical features, treatment modalities, and clinical outcomes of patients with hidradenitis suppurativa and compared the clinical outcomes of treatment modalities. Results: A total of 77 patients were enrolled. Male patients were predominant, and the mean age was 28.1 years. Buttock (42.0%) was the most commonly affected site and 63 patients (81.8%) had lesions at Hurley stage I. Forty-eight patients (62.3%) were treated with systemic antibiotics and 29 (37.7%) with systemic retinoid. Seventy-one patients (92.2%) showed improvement after a mean treatment duration of 8.3 weeks, and 69 (89.6%) experienced recurrence after improvement. Systemic antibiotics showed a relatively high improvement rate, short mean treatment duration, and low recurrence rate compared with systemic retinoids, but the differences were not statistically significant. Among systemic antibiotics, both tetracycline and macrolide showed good therapeutic effects for HS, but the differences were also not statistically significant. Conclusion: In this study, systemic antibiotics were associated with superior treatment outcomes compared to systemic retinoids, though without statistical significance. In the case of mild lesions, treatment with systemic retinoids appears to show comparable effectiveness to systemic antibiotics. (Korean J Dermatol 2017;55(10):651∼656)
심현수 ( Hyun Soo Sim ),설정은 ( Jung Eun Seol ),전지승 ( Ji Sung Chun ),최준희 ( Jun Hee Choi ),서종근 ( Jong Keun Seo ),이드보라 ( Deborah Lee ),성호석 ( Ho Suk Sung ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.12
A 68-year-old woman presented with erythematous indurated plaques on both her eyebrows. The skin lesions appeared 3 months after she was tattooed on both eyebrows. On histopathologic examination, a granulomatous infiltration was observed in the dermis with no evidence of any fungal, mycobacterial organisms. She was treated with intralesional injection of triamcinolon acetonide, but there was no improvement. After she started to take allopurinol for 5 months, the skin lesion improved without side effects. To the best of our knowledge, this is the first case of foreign body granuloma that was successfully treated with allopurinol in the Korean dermatologic literature. (Korean J Dermatol 2010;48(12):1108∼1110)