Molluscum Contagiosum Mimicking Verruca Vulgaris on the Sole

석승휘,윤문수,신정우 대한피부과학회 2023 Annals of Dermatology Vol.35 No.-

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백반증의 발병기전

석승휘,김동현 대한의사협회 2020 대한의사협회지 Vol.63 No.12

Vitiligo is an autoimmune disease in which CD8+ T-cells target and destroy melanocytes, leaving areas of skin without pigment production. Nonsegmental vitiligo, the classical form of the disease, results in symmetrical, bilateral white patches. Vitiligo is a chronic, unpredictable disease, characterized by flares, with depigmentation and periods of disease arrest alternating. This process can be stressful and negatively impact one’s quality of life. Various hypotheses have been offered, including cellular stress causing degeneration of melanocytes, chemical toxicity causing melanocyte death, and neural changes that influence melanocytes or their ability to produce melanin. Recently, the interaction between oxidative stress and autoimmune-mediated melanocyte loss has been proposed as the primary pathogenesis of vitiligo. It is now well accepted that interferon-γ and/or C-X-C motif chemokine ligand 10 axis is functionally required for both progression and maintenance of vitiligo, making this pathway a potential therapeutic target. Most therapeutic interventions in the management of vitiligo have been developed based on this immunopathogenesis. This article aims to review the current understanding of the vitiligo pathogenesis.

치유된 대상포진 부위에 발생한 판상건선: Wolf ’s Isotopic Response

석승휘,신정우,김현정,이희정,윤문수,김동현 대한건선학회 2019 대한건선학회지 Vol.16 No.2

Wolf’s isotopic response (WIR) refers to the occurrence of a new skin disorder at the exact site of another unrelated skin disease that had previously healed. Until recently, controversy has surrounded the definitions of WIR and isomorphic response – also known as the Köebner phenomenon–which describes the development of the same disease at a site with damaged skin. A 37‑year‑old female who had suffered from herpes zoster 5 months ago presented with a rash that had been present for the preceding 4 months, over the healed lesions of herpes zoster, corresponding to the right thoracic dermatomes T9– T10. Physical examination showed multiple erythematous scaly plaques over the right trunk. Histopathologically, it was consistent with psoriasis, and there was no evidence of herpetic cytopathologic changes. The patient received treatment with topical calcipotriol/betamethasone and methotrexate and nearly complete improvement was seen after 2 months.

건선관절염을 동반한 건선 환자에서 adalimumab 치료 중 발생한 급성골수성백혈병 1예

석승휘,안지혜,이선구,이희정,윤문수,김동현 대한건선학회 2018 대한건선학회지 Vol.15 No.2

Adalimumab, a fully human anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody, which has been successfully used in the treatment of several immune-mediated disorders including psoriasis. Hematologic malignancies or lymphoproliferative disorders associated with the use of TNF-α inhibitors in psoriatic patients have been reported. A 62 years-old male patient presented with plaque psoriasis for 20 years’ duration. Although he had received narrowband ultraviolet B phototherapy for 3 years and oral methotrexate for 6 months, none of them were satisfactory. The patient also complained of pain in multiple joints and onycholysis. Psoriatic arthritis was diagnosed based on the Classification criteria for psoriatic arthritis (CASPAR). He started to receive the treatment of subcutaneous injection of adalimumab 40 mg according to the dosing schedule of plaque psoriasis. During loading dose and initial six months, psoriatic skin lesion and arthralgia improved gradually. After 16 injections of adalimumab, the patient complained of myalgia, headache, and fatigue. Blood tests showed marked leukocytosis, anemia and low platelet counts, and the blast count was 45%. The patient was diagnosed with acute myeloid leukemia (AML) by additional bone marrow tests. Herein, we report a case of AML during the treatment with adalimumab to raise the awareness of the rare possibility of hematologic malignancy. Key Words: Adalimumab, Leukemia

Lupus Vulgaris Mimicking Tinea Corporis

석승휘,윤문수,김동현 대한피부과학회 2023 Annals of Dermatology Vol.35 No.-

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비결핵성 항산균과 연관된 유육종증 1예

석승휘 ( Seung Hui Seok ),신정우 ( Jung U Shin ),김현정 ( Hyun Jung Kim ),이희정 ( Hee Jung Lee ),윤문수 ( Moon Soo Yoon ),김동현 ( Dong Hyun Kim ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.7

Sarcoidosis is a multisystem granulomatous disease of unknown etiology. A range of factors including tuberculous infection, beryllium exposure, and cold climate have been implicated in the pathogenesis of the condition. A 45-year-old woman presented with a 4-month history of an asymptomatic eyelid swelling and multiple erythematous papules on the neck. Histological examination of the neck, orbital soft tissue, and lacrimal gland was consistent with sarcoidosis. Ziehl-Neelsen stains and polymerase chain reactions (PCRs) for tuberculosis on the skin biopsy specimens were negative. However, the orbital soft tissue specimen was positive for non-tuberculous mycobacteria (NTM) PCR. The patient was finally diagnosed with sarcoidosis associated with NTM. Treatment with systemic steroid and hydroxychloroquine was started, resulting in an improvement of skin lesions. We herein report a case of sarcoidosis associated with NTM infection with review of the literature, as only little is known regarding the role of mycobacteria in sarcoidosis. (Korean J Dermatol 2020;58(7):483∼486)

고관절용 인공관절 시스템의 안정성 평가

석승휘(Sung Fie Seok),박수(Soo Park) 대한기계학회 2012 大韓機械學會論文集A Vol.36 No.9

인공관절은 관절부의 뼈가 파괴되거나 관절 손상을 입어 관절로서의 기능을 할 수 없게 된 경우에 사용된다. 고관절용 인공관절 시스템의 일차안정성을 평가하기 위해서는 인공관절이 삽입된 직후 인공관절에 반복하중을 가하여 대퇴골과 인공관절 사이의 상대변위를 측정하게 된다. 이때, 정확한 안정성을 평가하기 위해서는 인공관절이 대퇴골을 파고드는 변위와 대퇴골에서 인공관절이 회전한 각의 변화량을 정확히 측정하여야 한다. 본 연구에서는 고관절용 인공관절 시스템의 일차안정성을 평가하기위해 새로운 상대 변위측정 방식을 제안하고 이를 이용하여 수술 방법의 차이 및 대퇴골 자체 강성의 차이에 따른 일차 안정성을 사체에서 얻은 대퇴골 실험을 통해 비교 평가하였다. Artificial joints are used when joints lose their function because of either the destruction or damage of the composing bones of the joints. To evaluate the primary stability of a femur-implant system, the relative displacement caused by a repeated load is measured immediately after the insertion of the artificial joint. For more accurate stability evaluation, the accurate measurement of the penetration displacement of the artificial joint to the bone and the rotation angle of the artificial joint is essential. In this study, to evaluate the primary stability of the femur-implant system, we propose a new relative displacement measurement method. By using this new method, we comparatively evaluate the primary stability for various surgical methods and the varying stiffness of the cadaver femur-implant itself.

혈중 총 면역글로불린 E가 증가된 건선 환자의 임상적 특징: 후향적 단일기관 연구

석승휘 ( Seung Hui Seok ),임태빈 ( Tae Bin Im ),신정우 ( Jung U Shin ),이희정 ( Hee Jung Lee ),윤문수 ( Moon Soo Yoon ),김동현 ( Dong Hyun Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2

Background: Psoriasis is a chronic T17 cell-driven immune-mediated inflammatory disease. However, patients with psoriasis may have elevated total serum immunoglobulin E (IgE) levels, which is a hallmark of Th2 inflammation. In previous case reports, psoriasis patients with elevated total serum IgE levels did not respond well to treatment or had exacerbated eczema lesions. Objective: We sought to investigate the clinical characteristics of psoriasis patients with elevated total serum IgE levels. Methods: This is a retrospective chart review of 130 patients with psoriasis who were tested for total serum IgE levels from November 1, 2009, to October 31, 2019. We compared the demographics, clinical characteristics, disease severity, and treatment regimen for each elevated IgE group (>214 U/mL) and normal IgE group (≤214 U/mL). Results: Among 130 patients with psoriasis, 41 (31.5%) had elevated total serum IgE levels. Elevated total serum IgE levels were positively associated with the severity of disease; psoriasis lesions including those on the scalp, hands, feet, and flexures, which are difficult to treat, were observed to be significantly higher in patients with elevated total serum IgE levels. There was no correlation between age, sex, disease duration, or presence of pruritus and total serum IgE levels. Conclusion: This study identified the clinical characteristics of psoriasis patients with elevated total serum IgE levels in Korea. (Korean J Dermatol 2021;59(2):94∼99)

힙조인트용 임플란트의 안정성평가 기법

석승휘(Sungfie Seok),박수(Soo Park) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.2

COVID-19와 건선

장윤경,석승휘,김동현 대한건선학회 2020 대한건선학회지 Vol.17 No.1

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) virus, has been spreading worldwide since December 2019. Most of COVID-19 patients exhibit mild-to-moderate symptoms and recover without sequelae, however some patients progress to acute respiratory distress syndrome or multiple organ failure, associated with high mortality. Psoriasis is chronic inflammatory disease represented by innate and adaptive immune dysregulation, which is targeted by immunomodulatory therapies. There is uncertainty concerning the outcome of COVID-19 infection in psoriasis patients who are receiving conventional immunosuppressive medications or biologic therapies. In this review, we will discuss about what dermatologists need to aware of and what we can help patients as dermatologists.