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여성의 주요우울증에 대한 노에스액(육울탕)의 안전성, 유효성 평가 : 무작위배정, 양측눈가림, 위약대조, 평행설계 임상시험 프로토콜
서영경 ( Young Kyung Seo ),이은희 ( Eun Hee Lee ),김환 ( Hwan Kim ),이지윤 ( Ji-yoon Lee ),박채린 ( Chae Rin Park ),최선영 ( Sunyoung Choi ),장은수 ( Eunsu Jang ),권오진 ( Ojin Kwon ),김형준 ( Hyungjun Kim ),정인철 ( In Chul Jung 대한한방신경정신과학회 2018 동의신경정신과학회지 Vol.29 No.1
Objectives: The aim of this trial is to evaluate the efficacy and safety of Yukwool-tang (Liuyu-tang) for the treatment of major depression in women by comparing the Yukwool-tang (Liuyu-tang)-treated group with the placebo-treated group and assessing the association of various biological factors related to depression through various outcome measures. Methods: This study is a single-center, randomized, double-blind, placebo-controlled, parallel-design clinical trial. The subjects to be selected are women between the ages of 19 and 65, and the registered subjects are to be randomly assigned to treatment with Yukwool-tang or the placebo control. The Yukwool-tang group will take 1 bottle of Yukwool-tang (30 mg) for 8 weeks, 3 times a day, before meals. The control group will take the placebo in the same way. The primary outcome to be examined will be the change between the total score after 8 weeks and the total score before the start of the study of the K-HDRS score. Secondary outcomes are assessed by the change in total score after 12 weeks of K-HDRS, K-HDRS remission rate, K-HDRS improvement rate, BDI-K, PITD, KSCL-95, ISI, STAI-K, EQ-5D, VAS, Emotional Stimulation Test, BDNF test, inflammatory cytokine and tumor necrosis factor test, intestinal microbiome test, dietary report and Beck's hopelessness scale. Results: This protocol has been approved by the IRB of Dunsan Korean Medicine Hospital of Daejeon University and is registered in the CRIS, and it is made public in advance to ensure transparency of the research process and conduct ethical clinical trials. Conclusions: Based on this protocol, when the trial is completed, its data can be used to access the validity and safety of Yukwool-tang for major depression in women, and it is also expected to be helpful in the study of the correlation between future treatment of Korean medicine for depression and related biological factors, and quality of life.
치매, 경도인지장애의 한의진료 현황, 진단 및 치료에 대한 한의사의 인식도 조사 연구 - 한방신경정신과 전문의와 일반의의 차이를 중심으로 -
서영경 ( Young Kyung Seo ),유동근 ( Dong Keun You ),김환 ( Hwan Kim ),김시연 ( Siyeon Kim ),이고은 ( Go Eun Lee ),김상호 ( Sang-ho Kim ),강형원 ( Hyung-won Kang ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2017 동의신경정신과학회지 Vol.28 No.3
Objectives: To identify the current status of Korean medical practice pattern, diagnosis and treatment of dementia through recognition survey, and to use it as a preliminary data for various dementia research. Methods: Questionnaires were developed through expert meetings. The disease was defined as dementia and mild cognitive impairment, and areas were designated to practice pattern, diagnosis and treatment. From December 18, 2016-January 18, 2017, 221 respondents, including 36 neuropsychiatrists of Korean Medicine and 185 general physicians (including other medical specialists) were included. Results: 1. In both groups, the most commonly used KCD (Korean standard classification of disease and cause of death) were in the order of Unspecified Alzheimer`s Dementia (F00.9), Mild Cognitive Impairment (F06.7), and Unspecified Dementia (F03). 2. The most commonly used pattern identification were zang-fu and qi-blood-yin-yang in both groups. 3. Diagnostic evaluation tools were mainly conducted by MMSE, radiologic examination, K-DRS, GDS and CDR in both groups. 4. Both groups reported using acupuncture and herbal medicine mainly. 5. In both groups, the acupuncture method was used extensively in the order of Body, Scalp, and Sa-Am. 6. Neuropsychiatrists used a variety of herbal medicines such as Wonjiseokchangpo-san (Yuanzhushichangpu-san), Yukmijihwang-tang (Liuweidihuang-tang), Palmijihwang-won (Baweidihuang-won), Sunghyangjungki-san (Xingxiang Zhengqi-san) and Ondam-tanggami (Wendan-tangjiawei). General physicians used a variety of herbal medicines such as Ondam-tanggami (Wendan-tangjiawei), Bojungikgi-tang (Buzhongyiqi-tang), Yukmijihwang-tang (Liuweidihuang-tang). 7. Neuropsychiatrists used a variety of Korean herbal preparation products (benefit and non-benefit) such as Ekgan-sangajinpibanha (Yigan-sanjiachenpibanxia), Yukmijihwang-tang (Liuweidihuang-tang), Jodeung-san (houteng-san), Palmijihwang-won (Baweidihuang-won). General physicians used a variety of Korean herbal preparation products such as Bojungikgi-tang (Buzhongyiqi-tang), Banhabaegchulcheonma-tang (banxiabaizhutianma-tang), Yukmijihwang-tang (Liuweidihuang-tang), Ekgan-sangajinpibanha (Yigan-sanjiachenpibanxia), Palmijihwang-won (Baweidihuang-won). Conclusions: By confirming awareness of Korean medical doctors treating dementia in clinical fields and understanding differences between neuropsychiatrists of Korean medicine and general physicians, it can be used to understand guideline users` needs and confirm clinical questions during development of future clinical practice guidelines for dementia.
이미영 ( Mi Young Lee ),김은정 ( Eun Jung Kim ),이희경 ( Hee Kyung Lee ),서영경 ( Young Kyung Seo ),이민선 ( Min Sun Lee ),고재숙 ( Jae Sook Koh ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.1
본 연구는 30대 43명(I군), 40대 75명(II군), 50대 34명(III군) 등 총 152명의 한국 여성을 대상으로 본 연구에서 수립한 육안평가 기준과 기기를 이용하여 눈가(crow's feet)주름을 정량화 하였다. 육안평가 기준은 Modified Daniell's Criteria를 미세 변화를 관찰할 수 있도록 10단계로 세분화하여 이용하였고, 기기평가는 Transparency Profilometry 기법을 이용한 Skin Visiometer SV 600 (Courage + Kahzaka)을 적용하였다. 각 방법의 측정값으로 1) 연령군별 주름의 정도를 비교하였고, 2) 연령군별로 좌우측간의 주름의 정도를 비교해 보았으며, 3) 본 연구에 적용한 육안평가 점수와 기기평가의 5개 주름 파라미터인 R1, R2, R3, R4, R5간의 상관성을 알아보았다. 육안평가 결과 연령이 증가할수록 육안평가 점수는 증가하였고, 각 연령군간에 통계적으로 유의한 차이가 관찰되었으나(P < 0.05), 모든 연령군에서 좌측과 우측의 육안평가 점수는 유의한 차이는 없었다. 기기평가 결과 연령이 증가할수록 5가지 주름 파라미터 모두 증가하는 경향을 보였고, 이중 연령군간 유의한 차를 보인 파라미터는 R1, R4, R5 였으며 (P < 0.05), R1과 R4는 I군과 III군 사이에 R5는 I군과 III군, II군과 III군 사이에서 유의한 차이를 나타내었다. 기기평가의 5가지 주름 파라미터 모두 좌우측간에 통계적으로 유의한 차이는 보이지 않았다(p < 0.05). 본 연구에 적용한 육안 평가 점수에 따라서 A군(0∼3 grade), B군(4∼6 grade), C군(7∼9 grade)으로 분류하여 기기평가 상의 5개 파라미터와의 상관성을 본 결과 R4와 R5가 A군다 C군 사이에 통계적으로 유의한 차이를 나타내었다(p < 0.05). 결과적으로 본 연구에서는 연령이 증가할수록 육안평가 점수와 5개의 주름 파라미터는 증가하였으나 좌우측간에 차이는 나타나지 않음을 알 수 있었다. 특히, 본 연구에서 적용한 육안평가 기준은 기기평가의 주름 파라미터 중 피부 주름의 평균 깊이와 피붜칠기를 나타내주는 R4와 R5를 더 정확히 반영함을 알 수 있었고, 미세한 주름의 변화를 읽을 수 있음을 알 수 있었다. In this study, we evaluated the crow's feet of 152 Korean women by using visual assessment established by our research group and mechanical assessment, Skin Visiometer SV 600. The volunteers were divided into 3 groups according to age; the group I of 30's was 43, the group II of 40's was 75, the group III of 50's was 34. The wrinkle score by visual assessment showed tendency to increase according to age and was statistically significant different among those three age groups (P < 0.05). But there was no significant difference between the left and the right of crow's feet. The 5 wrinkle parameters (R1, R2, R3, R4, R5) of mechanical assessment varied as age and the R1, R4, and R5 showed statistically significant difference among three age groups (P < 0.05). However there was no significant difference between the left and the right of crow's feet. The volunteers were divided into 3 groups according to wrinkle score; (0-3 grade for group A, 4-6 grade for group B, 7-9 grade for group C). Only R4 and R5 showed significant difference between group A and group C (P < 0.05). It was suggested that visual scoring criteria applied in this study was related to R4 and R5 and was useful in investigating in fine wrinkles.
신경성 식욕부진증에 대한 한약치료, 인지행동치료 및 인간중심상담치료 병행 1예 보고
허미숙 ( Misuk Her ),김환 ( Hwan Kim ),서영경 ( Young-kyung Seo ),양창섭 ( Changsop Yang ),이미영 ( Mi-young Lee ),장익순 ( Ik-soon Jang ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2017 동의신경정신과학회지 Vol.28 No.3
Objectives: To evaluate the effects of concurrent therapy with cognitive behavior therapy and person-centered counseling in addition to general Korean herbal medicine treatment for a patient with anorexia nervosa. Methods: A patient diagnosed with anorexia nervosa was treated with Korean herbal medicine treatment, cognitive behavior therapy, and person-centered treatment. The results were evaluated through a feeding interview, self-checklist, beck depression inventory (BDI) and InBody test. Results: After the treatment period, the treatment effects such as improvement of dietary restriction and elimination behavior, weight gain, and reduced depression were confirmed. Conclusions: This study suggests that concurrent therapy together with cognitive behavior therapy, person-centered counseling, and general Korean herbal medicine treatment is effective on patients with anorexia nervosa.
서영경,이성국 韓國學校保健學會 1992 韓國學校保健學會誌 Vol.5 No.1
The purpose of this study was to find family characteristics, habit of dietary intake, physical exercise, and mothers' concern related to obesity through questionaires among 5th grade children of 5 emementary schools in Taegu city from May 29th to June 8th, 1989. The data used in this study were collected from 245 obese children and 327 normal children by Body Mass Index with their body weight and height, and measurement of Triceps Skinfold Thickness. The findings were as follows : 1. This survey revealed that Triceps Skinfold Thickness was 11.0 mm in the obese group and 7.5 mm in normal group. Their parents body weight and BMI of the obese group were higher than those of the normal group. 2. Ending of weaning of the obese group had a faster tendency than that of the normal group. 3. It showed that the children of obese group had a hearty appetite during the evening meal and children of the normal group did so in lunch time. 4. The normal group was willing to take exercise but the obese group was not so. 5. Mothers of the obese group showed deeper concern at quantity of dietary intake and physical exercise than mothers of the normal group for their children's health.