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- 저자 : 서미영(Mi Young Suh) (검색결과 20 건)
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Effects of Dietary n-3 Fats on Hepatic Glucose-6-Phosphate Dehydrogenase and Malic Enzyme in Rat
서미영,김혜명,나혜경,조성희,Suh, Mi-Young,Kim, Hae-Myung,Na, Hae-Kyung,ChoLee, Sung-Hee Korean Society for Biochemistry and Molecular Biol 1990 한국생화학회지 Vol.23 No.3
To examine the effects of dietary n-3 fats on activities of hepatic glucose-6-phosphate dehydrogenase(G6PDH) and malic enzyme(ME), mackerel oil(MO) and perilla oil(PO) were fed to two groups of Sprague-Dawley rats of both sexes weighing 65-75 gm at the levels of 10%(w/w) in synthetic diets. Two other groups of rats were given soybean oil(SO) and beef tallow(BT) at the same level as dietary fats. After three weeks of feeding, male and female rats on same diet were mated and the effects of dietary fats were studied in their offsprings during early growth. Sex difference was also evaluated. Activities of G6PDH and ME increased steadily during growth of rats fed MO, SO and PO in the ascending order, while rapidly in BT group. After twelve weeks of feeding, the two enzyme activities were lowest in MO group, which was followed by SO, PO groups and highest in BT group. As dietary fat varied, differences in enzyme activities were more distinctive in male than in female. Fatty acid compositions of liver triglyceride and phospholipid showed that levels of $C_{20:5}$, $C_{22:6}$(n-3) increased in MO group, those of $C_{18:2}$, $C_{20:4}$(n-6), in SO group, $C_{18:3}$, $C_{20:5}$(n-3) in PO group, and $C_{16:0}$, $C_{18:0}$ did in BT group. However, increases in $C_{20-22}$(n-3) of MO group were much higher than those in $C_{18-20}$)(n-3) of PO group. It is suggested that the changes in tissue fatty acid pools modulate the activities of G6PDH and ME via several possible mechanisms. 식이 n-3 지방이 간장의 glucose-6-phosphate dehydrogenase(G6PDH)와 malic enzyme(EM) 활성에 미치는 영향을 조사하기 위하여 65-75 mg의 Sprague-Dawley종의 암, 수 흰쥐에게 고등어유와 들깨유를 조제식이의 10%(w/w)로 주어 사육하고, 비교군으로 대두유와 쇠기름을 준 두 군을 사용하였다. 3주 식이 후, 암, 수 쥐를 교배시키고, 태어난 새끼 쥐들의 초기 성장기간 동안 두 효소의 활성을 측정하고, 암, 수의 차이도 조사하였다. 젖을 먹는 동안 G6PDH와 ME 활성은 모든 군에서 매우 낮았고, 젖을 떼면서 효소활성은 증가하기 시작하였는데 쇠기름군은 급격한 증가를 보인 반면, 고등어유, 들깨유, 대두유군에서의 활성증가는 완만하고, 세 군간의 차이는 별로 없었다. 그러나 12주의 식이를 거친 고등어유군에서의 두 효소의 활성은 다른 식이군에 비하여 현저히 낮았다. 또한, 대두유군과 들깨유군도 쇠기름군보다 낮았는데, 이러한 현상은 숫쥐에서 더 뚜렷하였다. 간장의 중성지방과 인지질의 지방산 조성을 보면, 고등어유군에서 $C_{20:5}$, $C_{22:6}$(n-3)가, 대두유군은 $C_{18:2}$, $C_{20:4}$(n-6)가, 들깨유군은 $C_{18:3}$, $C_{20:5}$(n-3)가, 쇠기름군에서는 $C_{16:0}$, $C_{18:0}$ 지방산들이 각각 타군에 비하여 높았다. 고등어유군의 $C_{20-22}$(n-3)의 증가가 들깨유군의 $C_{18-20}$(n-3)의 증가보다 높은 것이 주목할만 하였다. 이러한 조직 지방산의 함량변화가 G6PDH와 ME 활성에 영향을 주는 요인으로 간주된다.
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서미영,조성희,Suh, Mi-Young,Cho, Sung-Hee 생화학분자생물학회 1986 한국생화학회지 Vol.19 No.2
식이 지방산 성분이 생체막 지질구성에 미치는 영향을 조사하고자 실험동물에게 고등어유, 대두유, 들깨유 및 고등어유+대두유(3 : 1)의 배합유를 식이중에 각 10%로 한 먹이를 24일간 섭취하게 한후 심장조직 미로콘드리아 내막의 지질구성에 미치는 변화를 조사하고 또 이런 구조의 변화가 생체막 기능에 영향을 미치는가를 보기 위하여 미토콘드리아의 호흡계 기능을 측정 하였다. 미토콘드리아 내막 인지질 구성은 고등어유군이 타군에 비해 phosphatidylcholine이 훨씬 높고 따라서 phosphatidylethanolamine은 낮았다. Cardiolipin도 고등어유군은 대두유군, 들깨유군보다 높았고 고둥어유와 대두유의 배합군도 고둥어유 단일군보다는 낮았으나 역시 식물유 단일군 보다는 높았다. 인지질 구성지방산의 조사결과, 고등어유군에서는 monounsaturated fatty acids 및 $C_{20-22}$의 ${\omega}3$ 지방산의 함량이, 대두유군에서는 $C_{18:2}$ (${\omega}6$)와 $C_{20:4}$ (${\omega}6$) 지방산의 함량이 타군들에 비해 각각 높았으나, 들깨유군에서는 $C_{18:3}$ (${\omega}3$) 및 총 ${\omega}3$ 지방산함량이 별로 높지 않았다. 들깨유군의 결과는, $C_{18:3}$ (${\omega}3$) 지방산의 elongation을 통해 $C_{20-22}$의 ($\omega3$) 지방산생성이 활발하지 않은 것으로 해석된다. 이러한 미토콘드리아 내막의 지질구성변화에도 불구하고, 식이지방에 따른 미토콘드리아의 state 3와 state 4 respiration율, P/O비, respiration control ratio, 그리고 ATP 합성에는 차이가 없었다. To examine the effect of dietary ${\omega}3$ fatty acids on cardiac mitochondrial inner membrane lipid composition and respiration, rats were fed diet containing 10% (w/w) mackerel oil and perilla oil for 24 days. The other two groups of rats were fed soybean oil and mackerel oil plus soybean oil (3:1) mix to compare the effect. Mitochondrial inner membrane phospholipid of mackerel oil group had higher content of phosphatidylcholine than phosphatidylethanolamine, the phenomena of which was reverse in vegetable oil groups. The amount of cardiolipin was the highest in mackerel oil group. Fatty acid composition of phospholipid was characteristic in each group, i.e., monounsaturated fatty acids and $C_{20-22}$ (${\omega}3$) fatty acids were higher in mackerel oil group, while $C_{18:2}$ (${\omega}6$) and $C_{20:4}$ (${\omega}6$) fatty acids were higher in soybean oil group, but neither $C_{18:3}$ (${\omega}3$) nor $C_{20-22}$ (${\omega}3$) fatty acids were significantly high in rats fed perilla oil, in which $C_{18:3}$ (${\omega}3$) comprises 60% of total fatty acids. This result suggests that elongation of $C_{18:3}$ (${\omega}3$) to $C_{20-22}$ (${\omega}3$) was not very active. These changes in the structure of mitochondrial inner membrane were not accompanied by any notable alteration in respiratory function of heart mitochondria.
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식이 n - 3 지방이 흰 쥐 간장의 Glucose - 6 - Phosphate Dehydrogenase 와 Malic Enzyme 활성에 미치는 영향
서미영,김혜명,나혜경,조성희 ( Mi Young Suh,Hae Myung Kim,Hae Kyung Na,Sung Hee Cho ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.3
To examine the effects of dietary n-3 fats on activities of hepatic glucose-6-phosphate dehydrogenase (G6PDH) and malic enzyme(ME), mackerel oil(MO) and perilla oil(PO) were fed to two groups of Sprague-Dawley rats of both sexes weighing 65-75 gm at the levels of 10%(w/w) in synthetic diets. Two other groups of rats were given soybean oil(SO) and beef tallow(BT) at the same level as dietary fats. After three weeks of feeding, male and female rats on same diet were mated and the effects of dietary fats were studied in their offsprings during early growth. Sex difference was also evaluated. Activities of G6PDH and ME increased steadily during growth of rats fed MO, SO and PO in the ascending order, while rapidly in BT group. After twelve weeks of feeding, the two enzyme activities were lowest in MO group, which was followed by SO, PO groups and highest in BT group. As dietary fat varied, differences in enzyme activities were more distinctive in male than in female. Fatty acid compositions of liver triglyceride and phospholipid showed that levels of C_(20:5), C_(22:6)(n-3) increased in MO group, those of C_(18:2), C_(20:4)(n-6), in SO group, C_(18:3), C_(20:5)(n-3) in PO group, and C_(16:0), C_(18:0) did in BT group. However, increases in C_(20-22)(n-3) of MO group were much higher than those in C_(18-20)(n-3) of PO group. It is suggested that the changes in tissue fatty acid pools modulate the activities of G6PDH and ME via several possible mechanisms.
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중년기 급성심근경색증 환자의 죽음불안과 사전연명의료의향서에 대한 지식 및 태도 간의 관계
서미영(Suh, Mi Young),김정선(Kim, Jeong Sun) 한국노인간호학회 2021 노인간호학회지 Vol.23 No.3
Purpose: This study aimed to identify the relationship between death anxiety, knowledge, and attitudes toward advance directives in middle-aged patients with acute myocardial infarction. Methods: Data were collected through a survey of 142 middle-aged adults from August 27th to October 4th, 2019 in G city. Data analysis was performed using descriptive statistics, t-test, one-way ANOVA, Scheffé test, and Pearson correlation coefficient. Results: The average score of participants’ death anxiety and attitudes toward advance directives was 44.14±6.71 and 43.61±3.53, respectively, and the average correct rate in knowledge of advance directives was 57.1%. Participants showed significant differences in death anxiety (F=3.75, p=.013), knowledge of advance directives (F=3.02, p=.033), and attitudes toward advance directives (t=2.31, p=.022) depending on the presence or absence of an object to discuss their health status. Also, there were significant differences in knowledge of advance directives (t=3.43, p=.001) and attitude toward advance directives (t=2.23, p=.027) depending on whether participants perceived the meaning of advance directives. There were positive correlations (r=.38, p=<.001) between knowledge of advance directives and attitudes toward advance directives in middle-aged patients with acute myocardial infarction. Conclusion: Active information-provision and promotional strategies are needed to enhance a correct understanding of advance directives for middle-aged acute myocardial infarction patients with a high probability of sudden death to recognize the need for an advance directive and reinforce a positive attitude.
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