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배도환,서대원 中央醫學社 1995 中央醫學 Vol.60 No.4
Unfortunately, some specific material therapeutic intervention, e.g., diethylstilbestrol or thalidomide, prescribed for problems associated with pregnancy (threatened abortion and nausea of pregnancy, respectively) have had many adverse effect on the conceptus. Given simplified presentations, the general public was convinced that the causes of congenital malformations were well understood and the defects preventable, that parents could be informed with certainty of the risks they would run in future pregnancy. Many published reports associated drugs or other agents with congenital malformations. Since it is impossible for anyone to know or remember everything about teratoloty, appropriate literature must be consulted. If the counselor dose so, the patient can be further reassured about the accuracy of the advice. During pregnancy, it would appear wise to avoid the administration of any drug which carries a suspicion of teratogenicity unless that drug is specially indicated. These recommendations would also apply to any woman of childbearing age in whom conception is likely.
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박선영,이영일,박형무,허민,서대원 대한폐경학회 1998 대한폐경학회지 Vol.4 No.1
"Estrogen deficiency is an important contributing cause of osteoporosis, and the resulting disabilities associated with vertebral and hip fractures. Hormone replacement therapy(HRT) at the time of the menopause has been shown to be effective in preventing menopause-related loss of mineral. However, estrogen therapy is not commonly recommended for older postmenopausal women because esttogens do not increase bone mass and are therefore ineffective in the treatment of established osteoporosis. However, recent studies found significant increases in Bone Mineral Density(BMD) of the spine in response to estrogen in older women but not in BMD of the femur. In this study, changes in BMD of the femur(neck, Ward's triangle and trochanter) in response to 1 year of HRT were evaluated by dual energy X-ray absorptiometry(DEXA) in postmenopausal women. One hundred seven women, naturally menopaused, received HRT with estrogen alone or in combination with progesterone, The purpose of this study is to analyze the effect of HRT on BMD of the femur in postmenopausal women in relation with years since menopause and initial bone mass. The results wete as follows; 1. Percentile increases in BMD of the femur(neck, 3.2%/year; Wards triangle, 1.7%/year; trochanter, 5.6%/year) occurred in response to HRT. 2, There was no correlation between the effect of HRT on BMD of the femur and years since menopause. 3. The changes in BMD of the femur(neck, Wards triangle, trochanter) in response to HRT were significantly related to the initial bone mass(neck, r 0.32; Ward's triangle, r= 0.41; trochanter, r 0.40). These results suggest that HRT significantly increases bone mass of the proximal femur as well as the lumbar spine and the response to HRT on BMD of the femur was greater in those had lower bone mass. Therefore, HRT may be effective in preventing osteoporotic fractures of the femur in older postmenopausal, osteopenic women. "
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