http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오미자칠해목 추출물의 과산화수소로 유발된 PC12뇌세포 사멸과 스코폴라민으로 유발된 렛드 동물모델에 대한 개선 효과
박은국,한경훈,허재혁,김남기,배문형,서영하,용윤중,정선용,최춘환,Park, Eun-kuk,Han, Kyung-Hoon,Heo, Jae-Hyeok,Kim, Nam-Ki,Bae, Mun-Hyoung,Seo, Young-Ha,Yong, Yoon-joong,Jeong, Seon-Yong,Choi, Chun-Whan 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.3
Cognitive impairment is considered to be key research topics in the field of neurodegenerative diseases and in understanding of learning and memory. In the present study, we investigated neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts in hydrogen peroxide-induced neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley<sup>®</sup> (SD) rat in vivo. Apoptotic cell death in neuroblastic PC12 cell line was induced by hydrogen peroxide for 1 hour at 100 μM. However, mixture of SC and RF treatment prevented peroxide induced PC12 cell death with no neurotoxic effects. For in vivo experiment, the effect of SC and RF extracts on scopolamine-induced cognitive impairment in SD rat was evaluated by spontaneous alternation behavior in Y-Maze test. After 30 min scopolamine injection, the scopolamine-induced rats presented significantly decreased % spontaneous alteration and acetylcholine level, compared to non-induced group. However, treatment of SC+RF extracts rescued the reduced % spontaneous alteration with acetylcholine concentration from hippocampus in scopolamine-induced rats. These results suggested that mixture of SC and RF extract may be a potential natural therapeutic agent for the prevention of cognitive impairment.
과산화수소로 유도된 SH-SY5Y 신경세포 사멸에 대한 오미자·칠해목 추출혼합물의 보호효과
박은국,한경훈,이승희,김남기,배문형,서영하,용윤중,정선용,최춘환,Park, Eun-kuk,Han, Kyung-Hoon,Lee, Seung-Hee,Kim, Nam-Ki,Bae, Mun-Hyoung,Seo, Young-Ha,Yong, Yoon-joong,Jeong, Seon-Yong,Choi, Chun-Whan 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.6
In neuronal cell deaths, oxidative stress is normally implicated with a most of these deaths occurring in neurodegenerative disorders such as the Alzheimer's and Parkinson's diseases. In this study, the neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts on hydrogen peroxide ($H_2O_2$)-induced oxidative stress in neuroblastic cell line were investigated. For an hour, hydrogen peroxide of $100{\mu}M$ concentration, was induced on neuroblastic cells, causing apoptic cell death. For the neuroprotection, a sample of neuroblastic cells had been pre-treated with SC and RF extracts for 24 hours before application of the hydrogen peroxide. No neurotoxic effects were observed in the cells that had been treated by SC and RF. This prove that the treatment of SC and RF extract prevented apoptotic cell death of neuroblastic cell line exposed to oxidative injury. In addition, applying both SC and RF extracts at a 7:3 ratio increased the neuronal cell survival rate, compared to individual treatments of SC and RF extract. This study suggests that SC and RF extracts may be potential therapeutic agents for the prevention of neuronal cell death.
아밀로이드 베타로 유도된 신경세포 사멸에 대한 PineXol<sup>®</sup>의 보호효과
한경훈 ( Kyung-hoon Han ),이승희 ( Seung-hee Lee ),박광성 ( Kwang-sung Park ),송관영 ( Kwan-young Song ),김정희 ( Jung-hee Kim ),박은국 ( Eun-kuk Park ),한성희 ( Sung-hee Han ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.6
Amyloid-β protein (Aβ) is known to increase free radical production in neuronal cells, leading to cell death by oxidative stress. The purpose of this study was to evaluate the protective effects of PineXol<sup>®</sup> on Aβ<sub>25-35</sub> induced neuronal cell death. Rat pheochromocytoma (PC-12) cells were pre-treated with 100 μg/mL of PineXol<sup>®</sup> for 2 h. The cells were exposed to single dose of 30 μM Aβ<sub>25-35</sub> for 24 h. Cell death was assessed by a cell count kit-8 (CCK-8) assay, lactate and dehydrogenase (LDH) release assay. An Apoptotic process was analyzed by a protein expression of the Bcl-2 family using western blotting. Cell viability increased in PC-12 cells treated with both Aβ<sub>25-35</sub> and PineXol<sup>®</sup>, compared to the control group. PineXol<sup>®</sup> induced a decrease of the Bcl-2 protein expression (p<0.05), while Bax and Sod1 increased (p<0.05), indicating attenuation of Aβ<sub>25-35</sub> induced apoptosis. These results suggest that PineXol<sup>®</sup> may be a good candidate for the prevention of Alzheimer’s disease(AD).