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신종 인플루엔자 A 유행 시 발열 시작과 신속 항원 검사 시행 사이의 시간 간격에 따른 민감도
박근화,박순빈,김성원 대한 소아알레르기 호흡기학회 2012 Allergy Asthma & Respiratory Disease Vol.22 No.1
Purpose:Rapid antigen test (RAT) is used to screen influenza rapidly. The clinical sensitivity of RAT was poor for 2009 H1N1 influenza. The aim of this study was to identify the correlation of time gap (TG) between fever onset and the sensitivity of RAT for 2009 H1N1 influenza. Methods:Data were collected retrospectively during the pandemic H1N1 2009 influenza season between October 2009 and February 2010. The RAT was done by using SD Bioline influenza antigen (Standard Diagnostics Inc.) in nasopharyngeal swab. The 2009 H1N1 influenza was confirmed by real- time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens were categorized according to the TG between fever onset and performance of RAT. They were classified into <24 hours (TG1), 24 to 48 hours (TG2), 48 to 72 hours (TG3), 72 to 96 hours (TG4), 96 to 120 hours (TG5), ˃120 hours (TG6). Results:The overall sensitivity of RAT was 69.9%. The TG dependent sensitivity of RAT at TG1, TG2, TG3, TG4, TG5, and TG6 was 64.3%, 73.3%, 61.1%, 88.9%, 83.3%, and 61.1% respectively. The sensitivity of RAT was the highest when the TG was 72 to 96 hours. But this result was not statistically significant. Conclusion:Correlation of TG between fever onset and the sensitivity of RAT for 2009 H1N1 influenza was not statistically significant. But our study suggested that 72 to 96 hours after fever onset is the most sensitive time of RAT. Timely optimal performance of the RAT could have a significant impact on improving results. Further evaluation for better sensitivity would be needed. 목 적:인플루엔자 신속 항원 검사(rapid antigen test, RAT)는 인플루엔자를 빠르게 선별하는 검사로 많이 사용되고 있다. 저자들은 신종 인플루엔자 A 유행 시 소아에서 RAT의 민감도와 발열 시작과 RAT 시행 사이의 시간 간격에 따른 민감도의 차이를 알아보았다. 방 법:2009 H1N1 인플루엔자 유행시기인 2009년 10월에서 2010년 2월까지 신종 인플루엔자 A 감염으로 입원한 환아를 대상으로 하였다. RAT는 비인두 면봉 검체(nasopharyngeal swab)를 이용하여 SD 바이오라인 인플루엔자 항원(Standard diagnostics Inc., Yongin, Korea)으로 시행하였다. 신종 인플루엔자 A는 RAT와 같은 시기에 시행한 동일한 검체를 이용하여 실시간 역전사 종합효소연쇄반응 검사 real-time reverse transcriptase polymerase chain reaction)로 확진하였다. 검체는 발열 시작과 RAT 시행 시기의 시간 간격에 따라 6개의 그룹으로 분류하였다. 시간 간격이 24시간 이내인 경우 TG1, 24-48시간인 경우 TG2, 48-72시간인 경우 TG3, 72-96시간인 경우 TG4, 96-120시간인 경우 TG5, 120시간 이후인 경우 TG6로 분류하였다. 각각의 그룹에서 RAT의 민감도를 계산하여 시간 간격에 따른 차이를 비교하였다. 결 과:채취한 모든 검체에 대한 RAT의 민감도는 69.9 %였다. 시간 간격에 따른 RAT의 민감도는 TG1 64.3%, TG2 73.3%, TG3 61.1%, TG4 88.9%, TG5 83.3%, 그리고 TG6 61.1%였으며 통계학적으로 차이가 없었다. 결 론:본 연구에서 신종 인플루엔자 A 유행 시 발열 시작과 RAT 시행까지의 시간 간격에 따른 RAT 민감도가 통계학적으로는 의미가 없었으나, RAT를 발열 시작 후 72-96시간에 시행하였을 경우 민감도가 가장 높았다. 소아에서 언제 RAT를 시행할 경우 민감도를 높일 수 있을지에 대한 추가적인 연구가 필요할 것이다.
박영진,박순빈,김성미,채유진,김종덕,정채림 대한신생아학회 2014 Neonatal medicine Vol.21 No.4
Microdeletion of 9q22.3 is a rare chromosomal disorder characterized by bodyovergrowth, facial dysmorphic features and psychomotor delay. The presence ofgenomic microdeletion or microdu-plication can not be identified by the conventionalchromosomal analysis. Microarray comparative genomic hybridization(CGH)is a newly developed molecular cytogenetic technique that enables the identificationof minute copy number variation (CNV) in the human genome. Here, we report acase of microdeletion in the 9q22.31-q22.33 region, which includeda patchedhomolog 1 (PTCH1) gene, as detected by CGH and confirmed by fluorescencein situhybridization (FISH) analyses in a neonate with prenatal onset of macrosomia,dysmorphism, and muscle hypotonia. To the best of our knowledge, this is the firstcase report of 9q22.3 microdeletion detected by CGH in Korea.
모형 가스터빈 연소기에서 NOx 배출량에 미치는 압력 및 비혼합도 효과 분석
왕위엔강,박순빈,손채훈 한국연소학회 2023 한국연소학회지 Vol.28 No.3
Pressure effects on NOx emission in a gas turbine combustor are numerically investigated in the present study. Initially, fully premixed flame condition with air and fuel injection at the combustor inlet is examined. Increasing pressure leads to a 0.08% rise in flame temperature and a significant 30% increase in NOx emissions. Technically premixed flame condition is then conducted. NOx emissions rise from 1.3 to 3 bar but decline beyond 3 bar due to combined pressure and mixing effects. Applying the NOx emission calibration formula, which accounts for pressure-induced changes while eliminating mixing influence, reveals a direct link between increased pressure and higher NOx emissions.
신종 인플루엔자 A 유행 시 발열 시작과 신속 항원 검사 시행 사이의 시간 간격에 따른 민감도
박근화 ( Geun Hwa Park ),박순빈 ( Sun Bin Park ),김성원 ( Sung Won Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.1
Purpose: Rapid antigen test (RAT) is used to screen influenza rapidly. The clinical sensitivity of RAT was poor for 2009 H1N1 influenza. The aim of this study was to identify the correlation of time gap (TG) between fever onset and the sensitivity of RAT for 2009 H1N1 influenza. Methods: Data were collected retrospectively during the pandemic H1N1 2009 influenza season between October 2009 and February 2010. The RAT was done by using SD Bioline influenza antigen (Standard Diagnostics Inc.) in nasopharyngeal swab. The 2009 H1N1 influenza was confirmed by real- time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens were categorized according to the TG between fever onset and performance of RAT. They were classified into <24 hours (TG1), 24 to 48 hours (TG2), 48 to 72 hours (TG3), 72 to 96 hours (TG4), 96 to 120 hours (TG5), >120 hours (TG6). Results: The overall sensitivity of RAT was 69.9%. The TG dependent sensitivity of RAT at TG1, TG2, TG3, TG4, TG5, and TG6 was 64.3%, 73.3%, 61.1%, 88.9%, 83.3%, and 61.1% respectively. The sensitivity of RAT was the highest when the TG was 72 to 96 hours. But this result was not statistically significant. Conclusion: Correlation of TG between fever onset and the sensitivity of RAT for 2009 H1N1 influenza was not statistically significant. But our study suggested that 72 to 96 hours after fever onset is the most sensitive time of RAT. Timely optimal performance of the RAT could have a significant impact on improving results. Further evaluation for better sensitivity would be needed.