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가속도계를 이용한 진전현상의 분석을 통한 파킨슨병과 본태성 진전의 판별
이홍지,이웅우,전효선,김상경,김한별,전범석,박광석,Lee, Hongji,Lee, Woongwoo,Jeon, Hyoseon,Kim, Sangkyong,Kim, Hanbyul,Jeon, Beom S.,Park, Kwangsuk 대한의용생체공학회 2015 의공학회지 Vol.36 No.4
Discrimination of Parkinson's disease (PD) from Essential tremor (ET) is often misdiagnosed in clinical practice. Since tremor is time-varying signal, and dominant and harmonic frequencies are shown in tremor only with moderate or severe symptom, there are some limitations to use frequency related features. Moreover, patients with PD or ET can suffer from both resting tremor and postural tremor. In this study, 28 patients with PD and 17 patients with ET were enrolled. Tremor was measured with accelerations on the more affected hand during resting and postural conditions. The ratio of root mean square (RMS) of resting tremor to RMS of postural tremor, the mean coefficients of autocorrelation function (ACF), and the mean of differences of two adjacent coefficients of ACF at resting and postural were calculated and compared between PD and ET. The performance showed 98% accuracy with support vector machine and leave-one-out cross validation. In addition, the method accurately differentiated the patients with tremor-dominant PD from patients with ET, with 100% accuracy. Therefore, the developed algorithm can assist clinicians in diagnosing and categorizing patients with tremor, especially, patients with mild symptom or the early stage of a disease, for proper treatment.
양손에서 웨어러블 시스템을 이용한 파킨슨병의 정량적 진전 평가
이홍지,김상경,김한별,전효선,박혜영,정유진,김정환,전범석,박광석,Lee, Hongji,Kim, Sangkyong,Kim, Hanbyul,Jeon, Hyoseon,Park, Hyeyoung,Jung, Yujin,Kim, Jeonghwan,Jeon, Beomseok,Park, Kwangsuk 대한의용생체공학회 2014 의공학회지 Vol.35 No.4
One of the methods for Parkinson's disease(PD) tremor evaluation is the Clinical Tremor Rating Scale(CTRS). However, the method has some limitations that clinician ratings can vary because the scores are subjectively rated. In addition, most researches usually collected data measured on the more affected arm. In this study, we developed a portable wearable system(SNUMAP system) for measuring PD tremor. The SNUMAP system captures 3-dimensional motion using tri-accelerometer and tri-gyroscope on finger and wrist. 40 PD patients participated in resting tremor and postural tremor tasks, while wearing the system on both hands simultaneously. Estimated tremor scores from Leave-One-Out Cross Validation for regression were highly correlated to the average clinician CTRS scores for rest tremor($r^2$ = 0.87, RMSE = 0.48) and postural tremor($r^2$ = 0.82, RMSE = 0.48). Therefore, the quantitative assessment model can improve treatment of PD patients.