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葦莖湯·加味葦莖湯의 A549에 對한 細胞毒性과 S-180에 對한 抗癌效果
김성훈,박정휘,박경식,김동희 대한동의병리학회 1995 동의생리병리학회지 Vol.9 No.2
연구배경 : 폐암은 최근 암사망률 중 17%로 위암과 간암에 이어 3위를 차지하고 있어 이의 치료와 연구는 중요한 과제로 등장하고 있다. 따라서 한의학적 측면에서 폐암에 해당되는 문헌을 찾아보아 이중 폐옹에 사용되는 길경탕과 최근에 각종 암에 다용되는 어성초, 白花蛇설초를 가미한 가미길경탕의 항암 효과 및 항암제와의 병용효과등을 현대적인 실험을 통하여 규명, 폐암에 대한 치료법을 제시하고자 함 방법 : in vitro에서 사람의 肺癌株인 A549에 對한 抗腫瘍效果와 cyclophosphamide(CPM), cisplatin(CPT), adriamycin(ARM), 5-fluorouracil(5-FU) 등의 4種 抗癌劑와의, 相乘作用을 살펴보고, ICR생쥐에 S-180을 腹腔 注射한 後 實驗 藥物을 口腔 投與하여, 生命延長率, 體重變化 및 血液檢査 등을 실시하였다. 결과 : 葦莖湯, 葦莖湯加魚腥草, 葦莖湯家伯花蛇舌草는 모두 肺癌에 對한 抗腫瘍效果가 認定되며, cyclophosphamide나 cisplatind을 倂用하거나 魚腥草나 白花蛇舌草를 加味하였을 경우 보다 效果的인 것으로 나타났다. In order to prove the antitumor effect of Wekyungtang(WKT) that was originated in Bigeubchunkeumyobang(備急千金要方), Wekyungtang with Houttuyniae Herba(WKT-I) and Wekyungtang with Oldenlandiae diffusae Herba(WKT-Ⅱ) on human pulmonary tumor cells experimentally, the studies were done. We evaluated the cytotoxic activity against A549 as well as the synergistic effects with anticancer drugs such as cyclophophamide(CPM), cisplatin (CPT), adriamycin (ARM) and 5-fluorouracil(5-FU) in vitro, and measured body weight, survival time, hematological changes in ICR bearing S-180. The results were obtained as follows: 1. IC50 against A549 was 16.24ug/ml in cyclophophamide (CPM), 8.01ug/ml in cisplatin(CPT), 8.39ug/ml in adriamycin(ARM) and 3.13 in 5-fluorouracil (5-FU) respectively. 2. Inhibitory effect on the adhesion of A549, the ratio of No. of antiadhesive cells to adhesive cells was 26.8/73.2 in WKT, 30.42/69.58 in WKT-Ⅰ and 35.12/64.88 in WKT-Ⅱ at the concentrations of 10-³g/ml, which indicates that antiadhesive effect was shown in the order of WKT-Ⅱ, WKT-Ⅰ, WKT. 3. In vitro the concentrations showing inhibitory growth rate below 55% of control against A549 was recognized in concentration of 10-³g/ml of WKT, the synergistic effect with CPM was shown in the concentration of 10-5 g/ml above of WKT, concentrations of WKT-Ⅰ, 10-³g/ml of WKT-Ⅱ, the syneristic effect with CPT was shown in the concentration of 10-5 g/ml above of WKT-Ⅱ, the synergistic effect with ARM was shown in concen -tration of 10-³g/ml of WKT-Ⅰ, WKT-Ⅱ, the synergistic effect with 5-FU was shown in concentration of 10-³g/ml WKT, WKT-Ⅰ, which indicated that CPT, CPM had the synergistic action with WKT. 4. In vivo, the gaining of body weight was significantly suppressed in all groups as compared with control group bearing S-180 and ILS was 10.45% in WKT, 16.43% in WKT-Ⅰ, 21.82% in WKT-Ⅱ respectively. 5. The number of platelet was significantly increased in WKT, WKT-Ⅰ and platelet aggregation was significantly increased in all roup as compared with control group. From the above results it was concluded that Wekyungtang and Kami-Wekyungtang had antitumor effect against A549 and wekyungtang combined with Houttuyniae Herba or Oldenlandiae difusae Herba was more effective than wekyungtang only, also cyclophophamide(CPM), cisplatin(CPT) exerted the more synergistic effect in the anticancer drugs.
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