알코올리즘으로 일 지역 상담 센터에 방문한 환자의 특성에 대한 연구

민은정(Eun Jeong Min),김성곤(Sung Gon Kim),김현경(Hyeun-Kyeung Kim),정봉주(Bong Joo Jung) 한국중독정신의학회 2016 중독정신의학 Vol.20 No.2

Objectives : The therapeutic approach for a patient with alcohol dependence should match the patient’s characteristics, determined before treatment initiation. However, most services provided for these patient by hospitals and community counsel-ing centers do not usually differ. We conducted this study to evaluate drinking history and cognitive function of patients with-in each institution, in order to design an effective treatment ap-proach. Methods : Alcohol-dependent patients visiting at a com-munity counseling center and a university hospital were included as study subjects and investigated for demographics and drink-ing history. In addition, we performed neuropsychological test-ing to evaluate IQ, memory, and executive function. Results :TSignificant differences were found in terms of duration of drink-ing and blackout detected for drinking and blackout duration between the patients visiting at community counseling center and a university hospital (drinking duration, 22.74±13.47 vs. 33.14± 13.75, p<0.05 and blackout duration, 9.79±9.41 vs. 18.43±13.21, p<0.05). Patients visiting at community counseling center start-ed drinking at an earlier age than the patients visiting at univer-sity hospital (11% vs. 32%, p<0.10). The patients visiting a com-munity counseling center had an executive function disability for IQ (χ=2.95, p=0.08). In addition, the patients visiting a com-munity counseling center started drinking at an earlier age than the patients visiting a university hospital (11% vs. 32%, p<0.10). Conclusion : These findings suggested that the patients visiting at a community counseling center started drinking earlier, had been drinking longer, and had poorer cognitive function than patients visiting at university hospital. Therefore, different ther-apeutic services should be offered based on these characteristics.

한국 여성의 임신 중 음주 행동

민은정(Eun Jeong Min),김성곤(Sung Gon Kim),이진성(Jin-Seong Lee),정우영(Woo Young Jung),이동형(Dong Hyung Lee),김희진(Hee Jin Kim),서재원(Jae Won Seo) 한국중독정신의학회 2012 중독정신의학 Vol.16 No.2

Objective : Drinking alcohol during pregnancy can result in various negative consequences. Several studies have been conducted in Korea in order to investigate alcohol consumption in pregnant women; yet, no study has investigated as to whether drinking habits of Korean pregnant women have changed overtime. There-fore, we compared the results of two surveys conducted in 1997 and 2008, investigating whether pregnant women drank alcohol before and during pregnancy. Method : Pregnant women who were <30 days before their expected delivery date and those who visited a specialized hospital for obstetrics in 1997 and 2008 were asked to complete a self-report questionnaire. Demographic and obstetric characteristics as well as the drinking history of pregnant women were investigated. Results : 1) Comparing the 2008 survey (n=478, group B) with the 1997 survey (n=731, group A), the average age and education level of group B were significantly ol-der and higher than those in group A (30.6±3.7 vs. 28.0±3.4 years, p<0.001 ; 14.6±1.8 vs. 13.5±2.1 years, p<0.001). Moreover, the proportions of women who had positive results on the CAGE test or who had a blackout history were significantly greater in group B than those in group A (17.8% vs. 11.8%, p<0.01 ; 27.6% vs. 8.9% ; p<0.001). 2) The rate of women who consumed alcohol before their last menstrual period (LMP) in group B was significantly higher than that in group A (83.3% vs. 78.5%, p=0.045). In contrast, the rate of women who consumed alcohol after LMP was significantly lower in group B than in group A (40.0% vs. 57.6%, p<0.001). Conclusion : Over a span of 11 years, pregnant women were older and had more alcohol-related problems ; yet, more pregnant women intended not to drink alcohol during their preg-nancy. These results suggest that an appropriate anti-drinking educational strategy for pregnant women might be needed in order to affect these changes.

오믹스 자료를 이용한 정준방법 비교

이승수,민은정,Seungsoo Lee,Eun Jeong Min 한국통계학회 2024 응용통계연구 Vol.37 No.2

Integrative analysis for better understanding of complex biological systems gains more attention. Observing subjects from various perspectives and conducting integrative analysis of those multiple datasets enables a deeper understanding of the subject. In this paper, we compared two methods that simultaneously consider two datasets gathered from the same objects, canonical correlation analysis (CCA) and co-inertia analysis (CIA). Since CCA cannot handle the case when the data exhibit high-dimensionality, two strategies were considered instead: Utilization of a ridge constant (CCA-ridge) and substitution of covariance matrices of each data to identity matrix and then applying penalized singular value decomposition (CCA-PMD). To illustrate CIA and CCA, both extensions of CCA and CIA were applied to NCI60 cell line data. It is shown that both methods yield biologically meaningful and significant results by identifying important genes that enhance our comprehension of the data. Their results shows some dissimilarities arisen from the different criteria used to measure the relationship between two sets of data in each method. Additionally, CIA exhibits variations dependent on the weight matrices employed.

알코올사용장애가 있는 숙고 전 단계 쪽방 노숙인에서 Rapport 형성을 강조한 통합사례관리 접근법 효과성에 관한 연구

나은경(Eun-Kyoung Na),김성곤(Sung-Gon Kim),정재현(Jae-Hyun Jung),이덕기(Duk-Ki, Lee),민은정(Eun-Jeong Min) 한국중독정신의학회 2017 중독정신의학 Vol.21 No.1

Objective : This study aimed to find the effectiveness of the integrated case management program, focused on sharing a rapport at precontemplation stage, in the Jjok-bang (small single room) homeless suffering from alcohol use disorder. Methods : A total of 19 subjects at the Jjok-bang (small single room) homeless, having alcohol use disorder at the precontemplation stage, were included if the study. Case management, group therapy, and network services focused on the rapport provided to them for 18 months (8 months for phase I, 10 months for phase II). Results : During phase I, 7 of the 19 homeless dropped out of the study, and the remaining 12 subjects maintained abstinence or reduced drinking at the end of phase I. In phase II, 8 subjects who desired admission enrolled in the study, and 7 (87.5%) of them reduced drinking, or kept abstinence at the end of phase II. Overall, of the subjects who participated in phase I, 42.1% completed phase II ; 7 subjects (36.8%) reduced daily drinking or maintained abstinence. Conclusion : These findings suggested that a program which emphasize on sharing a good rapport between the therapist and subject is effective for the homeless who suffer from alcohol use disorder at the precon-templation stage.

자폐스펙트럼장애 아동의 치료개입시기에 영향을 미치는 요인 : 후향적 분석

유은라(Yu, Eun-ra),김지훈(Kim, Ji-hoon),민은정(Min, Eun-jeong),서비아(Seo, Bi-A),최진혁(Choi, Jin-Hyeok),최범성(Choi, Bum-Sung) 한국자폐학회 2020 자폐성 장애연구 Vol.20 No.1

본 연구의 목적은 자폐스펙트럼장애 아동의 부모가 자폐증상을 인지한 이후, 보다 빠른 치료적 개입시작에 영향을 미치는 요인을 파악하는 데 있다. 연구대상은 B 대학병원에 내원한 만 2세부터 만 6세 사이의 자폐스펙트럼장애 아동 170명을 대상으로 하였다. 연구방법은 빈도 및 기술통계분석, 독립표본 t-검정, 상관관계분석, 다중회귀분석을 실시하였다. 연구결과, 아동이 다른 아이들과 다름을 인지한 시기는 평균 생후 20개월 시점인 것으로 확인되었고, 치료를 처음 시작한 연령은 35.5개월로 아동의 증상을 인지하고 치료시작까지 걸리는 시간은 평균 14.5개월 소요되는 것으로 확인되었다. 영향요인 분석 결과, 아동의 일상생활능력 중 사회성과 부모상호작용 중 지시성이 낮고, 상동행동적인 문제가 심하며, 모의 학력이 더 높을수록 치료적 개입이 보다 조기에 이뤄지는 것을 확인하였다. 이에 영향을 미치는 요인들이 자폐스펙트럼장애 아동의 원활한 치료를 위해 활용되도록 제언하였다. The purpose of this study was to investigate the factors that affect the initiation of therapeutic intervention after parental awareness of autism symptom in children with autism spectrum disorder(ASD). We studied 170 children with ASD from 2 to 6 years old who visited B National University Hospital. The research methods were frequency, descriptive statistical analysis, independent sample t-test, correlation analysis, and multiple regression analysis. According to the results, when the average age child was about 20.8 months, the parents recognized the child s autism symptoms and the average age of starting intervention was 35.5 months. The average time to start therapeutic intervention after parents recognized the child s autism was 14.5 months on average. The timing of intervention for children with ASD was faster as the less sociality in the daily life area of the children, the lower the direction among the parent interactive behavior scale, the more severe the symptoms of stereotypic behavior patterns and the higher the mother s educational background of the children. It was suggested that the factors affecting the initiation of therapeutic intervention be used for the early intervention of children with ASD.

광학단층기법 기반의 바이오/의료영상 및 정밀계측 기술

이병하,김영호,민은정,Lee, Byeong-Ha,Kim, Yeong-Ho,Min, Eun-Jeong 한국광학회 2013 광학과 기술 Vol.17 No.1

알코올리즘 가족력이 있는 한국인 사회적 음주자에서 심리적 스트레스가 타액 코티졸 농도에 미치는 영향

서유나(Yuna Seo),김성곤(Sung-Gon Kim),민은정(Eun-Jeong Min),김진미(Jinmi Kim),박문일(Moon-Il Park),김수연(Soo-Yeon Kim),김대욱(Dae-Wook Kim),변원탄(Won-Tan Byun),김지훈(Ji-Hoon Kim) 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.2

Objectives:A number of studies have shown dysregulation of the hypothalamus-pituitary-adrenal axis in alcoholics. The aim of the present study was to determine whether there are differences in salivary cortisol responses to a psychological stressor between nonalcoholic offspring from families with a history of alcoholism and those without a family history of alcoholism in Korea. Methods:We studied 45 healthy social drinkers, who were medical students aged≥18 years. The participants completed a baseline assessment and, salivary cortisol levels were obtained. All subjects were exposed to almost 15 minutes of stress. Immediately following completion of the stress exposure, four additional salivary specimens were obtained for cortisol levels at 15 minute intervals. The subjects were divided into two groups those who reported a history of alcoholism in either parent(FHP, n=9) and those who reported no alcoholism in their family for three generations(FHN, n=30). Results:A significant difference in salivary cortisol by family history group(p<.001), and by time was discovered (p=.005) with a repeated-measures ANOVA. Basal salivary cortisol levels in FHP subjects were significantly higher than those in FHN subjects(p=.003). After stress exposure, salivary cortisol levels decreased significantly over time in the FHN group, whereas they did not in the FHP group. Conclusion:FHP subjects had higher baseline salivary cortisol concentrations than those of FHN subjects and maintained the levels after stress. This finding suggests that social drinkers with a history of alcoholism in a parent have increased vulnerability to stress and difficulty coping with stress effectively.

유지 혈액투석치료를 받는 만성신부전에 수반된 우울증에서 항우울제 치료에 따른 우울증상 및 영양지표의 변화

정연순 ( Yeon Soon Jung ),박시성 ( Si Sung Park ),민은정 ( Eun Jeong Min ),한병호 ( Byung Ho Han ),엄은아 ( Eun A Eum ),임학 ( Hark Rim ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.1

목적: 유지 혈액투석치료를 받고 있는 만성신부전 환자에서 수반되는 우울증과 우울증상의 특성 및 정도를 조사하고, 항우울제 치료 전후의 우울증상 및 영양지표의 변화를 측정하여, 우울증과 우울증상의 치료가 유지 혈액투석치료를 받고 있는 만성신부전 환자에게 미치는 임상적 영향을 살펴보고자 하였다. 방법: 고신대학교 복음병원 인공신장실에서 6개월 이상 동안 유지 혈액투석치료를 받고 있는 만성신부전 환자 64명을 대상으로 우울증 및 우울정도와 영양상태 지표들을 조사하였다. 주요우울증의 진단은 반구조화된 면담을 통하여 DSM-IV TR 기준을 사용하였다. 우울증상의 정도는 17문항의 Hamilton Rating Scale for Depression (HRSD)을 사용하여 측정하였다. Subjective global assessment (SGA), body mass index (BMI), triceps skin fold thickness (TSF), mid-arm muscle circimference (MAMC)와 handgrip strength를 측정하였으며 KT/V, normalized protein catabolic rate (nPCR), 혈청 알부민 농도 등과 같은 영양지표도 측정하였다. 우울증이 있는 경우 8주간의 항우울제 약물치료를 시행하였고, 치료 이후 우울증상과 영양상태의 항목들을 재평가하였다. 결과: 만성신부전으로 유지 혈액투석치료를 받고 있는 환자들 중 우울증으로 진단된 환자는 19명으로 42.2% (주요 우울장애 11명 24.4%, 기분부전장애 8명 17.8%)였다. 우울증이 있는 경우 우울한 기분, 죄책감, 자살사고, 수면장애, 일과 활동의 저하, 정신운동의 지연, 정신적 불안 및 신체 불안, 전반적인 신체증상 및 건강염려 등이 유의하게 높았다. 항우울제 약물치료 후 우울한 기분과 정신적 불안, 죄책감, 자살사고, 일과 활동, 수면장애 및 전반적인 신체증상 등이 유의하게 호전되었다. 치료 후 TSF (p<0.05), handgrip strength (p<0.01)와 hematocrit (p<0.05)이 개선되었다. 결론: 유지 혈액투석 중인 만성신부전 환자에서 우울증이 수반될 경우 우울증상에 대한 항우울제 치료는 수면과 신체증상 등을 포함하여 우울증상을 호전시킬 뿐만 아니라 삶의 질을 향상시킬 것으로 기대되므로 적극적인 항우울제 치료가 필요하다고 하겠다. Purpose: Depression is common in patients with chronic renal failure on maintenance hemodialysis, though success rate of treatment is low. This study aimed to investigate the features and severity of the depressive symptoms and nutritional indices, and significant changes after antidepressant treatment. Methods: The authors assessed 45 patients. Diagnosis of depression was made using DSM-IV-TR and the depressive symptoms were evaluated using Hamilton Rating Scale for Depression via semistructured interview. Subjective global assessment, anthropometric measurements and nutritional indices such as Kt/V, nPCR were examined. Depressive patients were treated for 8 weeks with SSRI (citalopram), and all the variables were examined again after the treatment. Results: 19 (42.2%) patients were diagnosed as depression. Nutritional status was not different between patients with depression and those without depression. Compared to non-depressed patients, depressed patients showed significantly higher depressed mood, guilty feeling, suicide idea, psychic and somatic anxiety, lower work and activities, psychomotor retardation, sleep disturbances, general somatic symptoms and hypochondriasis. After antidepressant treatment, depressed mood, guilty feeling, suicide idea, psychic anxiety, initial insomnia, middle insomnia, early awakening, work and activities and general somatic symptoms were improved significantly. TSF (p<0.05), handgrip strength (p<0.01) and hematocrit (p<0.05) were significantly increased. Conclusion: Antidepressant treatment is helpful not only for the improvement of depressive symptoms such as sleep and somatic symptoms but for the improvement of quality of life. Proper treatment should be more actively attempted for the hemodialytic patients with depression.

음주문제를 보이는 여자 대학생들의 기질적인 특성

정재훈(Jae-hoon Chung),김성곤(Sung-Gon Kim),민은정(Eun-Jeong Min),유희정(Hee-Jung Yu),서비아(BiA Seo),나은경(Eun-Kyoung Na),허성영(Sung-Young Huh) 한국중독정신의학회 2018 중독정신의학 Vol.22 No.2

Objectives : It is essential to determine the traits of female college students for early and effective prevention of any psychiatric or psychological disorder. Temperament is regarded as one of the important risk factors resulting in alcohol abuse. We investigated the differences in the scores of Temperament and Character Inventory (TCI) between female college students with and without alcohol abuse based on The Korean version of Alcohol Use Disorders Identification Test (AUDIT-K). Methods : The subjects included 127 female college students in Pusan, Korea. All subjects were assessed via alcohol-related questionnaires, AUDIT-K and TCI. Results : The subjects were divided into 2 groups based on the results obtained : alcohol use disorder group [N=33 (26.0%), score of AUDIT-K≥12] and control group [N=94 (74.0%)]. The mean scores of Harm-Avoidance (HA) behavior were significantly lower (t=-3.045, p=0.003), and Novelty- Seeking (NS) trait was significantly higher (t=1.883, p=0.062) in the group with alcohol use disorder than in the control group. Conclusion : It is likely that female college students with alcohol abuse manifest less HA and an increased level of NS temperament traits. In order to effectively prevent alcohol use disorder in female college students, it is imperative to determine the temperament traits using TCI.

알쯔하이머병과 5-HTTLPR 다형성

조득만 ( Deuk Man Cho ),박성우 ( Sung Woo Park ),주명진 ( Myung Jin Joo ),이봉주 ( Bong Ju Lee ),민은정 ( Eun Jeong Min ),남정숙 ( Jeong Sook Nam ),공보금 ( Bo Geum Kong ),김영훈 ( Young Hoon Kim ),김호찬 ( Ho Chan Kim ) 한국정신병리진단분류학회 2002 精神病理學 Vol.11 No.1