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구강 편평세포암종, 백반증 및 유두종에서 Human Papillomavirus(HPV) 유형 16/18의 분포에 관한 면역조직화학적 연구
민우석(Woo Seok Min),이의웅(Eui Wung Lee),김진(Jin Kim) 대한구강악안면외과학회 1993 대한구강악안면외과학회지 Vol.19 No.4
There have been many reports on the etiological role of HPV in various oral diseases including carcinomas. Present study was performed to elucidate the distribution of HPV 16/18 in oral squamous cell carcinomas, leukoplakias and papillomas of Koreans. 24 cases of squamous cell carcinomas, 7 cases of leukoplakias and 6 cases of papillomas were reviewed through immunohistochemical staining using anti-HPV 16/18 E6 monoclonal antibody. Obtained results were as follows: 1. Positive reactions were observed in 6 cases out of 24 squamous cell carcinomas, Among the 6 positive cases 3 cases showed positive reaction both in the tumor cells and the adjacent epithelial cells, whereas the remaining 3 cases only in the adjacent epithelial cells. 2. 4 cases out of 7 leukoplakias reacted positively, all of which showed no dysplasia. 3. Positive stainings were observed in 4 cases out of 6 papillomas. These results confirm HPV involvement in oral papilloma, leukoplakia an squamous cell carcinoma, and support the hypothesis of HPV as an etiological agent in oral carcinogenesis. However, the frequency of positive reaction was much higher in benign lesions such as papillomas and leukoplakias, than in malignant lesions like squamous cell carcinomas. Therefore, HPV may be thought to be a co-factor in oral carcinogenesis together with chemical factor, rather than a single factor. And further studies will be needed to elucidate the role of HPV in oral carcinogenesis.
최근 6년간 연세의료원에서 경험한 한국인 안면골 골절에 대한 임상적 연구
권준호,이충국,이의웅,민우석,윤중호,박형식 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1
This is a series of continuing research on facial bone fractures of Koreans worked by Dept. of Oral and Maxillofacial surgery, Dental College of Yonsei University, Seoul, Korea, since 1972. The study was based on a series of 630 patients with facial bone fractures treated as in patient at Yonsei Medical Center, Yonsei University, during the period of Jan. 1982 through Dec, 1987. The results obtained are as follows: 1. The ratio of Men to Women was 4.3 : 1, and admissions for facial bone fractures have been increased year after 1984. 2. The age frequency was highest in the third decade(38.3%). and fourth, second, fifth decade in orders. 3. The traffic accident was the most frequent cause of facial bone fractures(51.3%). 4. The most common location of facial bone fractures was the Mandible(35.3%), and Zygoma complex(29.8%), Nasal bone(15.0%), Maxilla(11.0%) were next in order of frequency. 5. In 291 patients of Mandible fractures, 226(77.7%) had fractures only in Mandible and 65(22.3%) had another facial bone fractures. The most frequent fracture site of mandible was the Symphysis(43.0%) and Angle(22.4%), and Simple fracture was the most frequent in type of fracture(66.9%). Intermaxillarty fixatin & Open reduction was major method of treatment(36.9%). 6. In 394 patients of Midface fractures 323(82.0%) had fractures only in Midface and 71(18.0%) had another facial bone fractures. The most frequent site of Midface fractures was zygoma complex & zygomatic arch(42.7%), and Simple fracture was the most common type of fractures. Observation(Maxilla :44.2%, Zygoma :51.0%) and Open Reduction(Maxilla :20.0%. Zygoma :23.5%) were the major method of treatment. 7. The frequency of Nasal bone fracture was about 1/5 of Midface fractures, and Closed Reduction(42.2%) was the major method of treatment. 8. The complication was reported in only 16 patients, and Malunion was the major complication. 9. Head(44.4%), Lower extrimities(14.5%) and Eye(12.3%) were injured commonly with facial bone fractures. 10. The elapsed time from injury to hospital was within 24 hours in 73.8% of patients, however 15.5% of patients arrived the hospital 72 hours after injury.