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신규 세파로스로린 항생제 DWC-751 합성과 물성연구
이재호,정종근,김명구,안상근,최영기,문치장,오세한,성무제,윤길중,신종만,김학형,김영도,박준우 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.1
The synthesis and physicochemical properties of a novel cephalosporin, DWC-751 are described. DWC-751, (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(1-methylbenzotriazol-3-ium)methyl]-ceph-3-em-4-carboxylate monosulfate(IV_a) was conveniently obtained by the conversion of compound(IV) into the crystalline monosulfate. Adjusting pH 4.8-5.2 in aqeous solution of the crude crystalline, compound(IV) in the form of a crystalline pentahydrate was prepared with a high degree of purity. The influence of the various organic and inorganic acids on the solubility of compoud(IV) and its salts, was examined. Particularly, the solubility of DWC-751 was 92 ㎎/㎖ at pH 1.7 and 233 ㎎/㎖ at pH 3.0. DWC-751 showed a broad antimicrobial spectrum against gram-positive and negative bacteria.