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뇌졸중 환자 음성언어의 Spectral times 연구
노혜미(Hye Mi Noh),강은영(Eun yeong Kang),김현기(Hyun Gi Kim) 한국언어치료학회 2016 한국언어치료학회 학술발표대회 논문집 Vol.2016 No.12
Purpose: Cerebrovascular accident(CVA) is caused by a lesion blocking an artery. The aim of this study is delineate the Acoustic characteristics in Basal ganglia intracerebral hemorrhage (BG) and Middle cerebral artery infarction (MCA) patients. Methods: Seven Basal ganglia intracerebral hemorrhages and seven Middle cerebral artery infarctions participated in this study. Average age is 54.2±8.4 years old. Fourteen control group were selected random by average 49.7±9.9 years old. The collection of speech and analysis of acoustics Praat was done for acoustic analysis. The test words were composed meaningful words. Results: 1) Spectral times of all the consonsnts in patients with the BG and the MCA patients were longer than control group. 2) The VOT of the stop consonants in BG and MCA patients showed a meaningful difference in the bilabial fortis stops and aspirated stops, alveolar fortis stops, and velar fortis stops and aspirated stops.
투과전자현미경을 이용하여 관찰한 건성안 유발 마우스 눈물샘 선세포의 변화
서유리,여아름,노혜미,정동룡,김태임,서경률,김응권,이형근,Yu Ri Seo,A Reum Yeo,Hye Mi Noh,Dong Yong Chung,Tae Im Kim,Kyoung Yul Seo,Eung Kweon Kim,Hyung Keun Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.8
Purpose: To determine the change in lacrimal gland (LG) acinar cells induced by in vivo dry eye (DE). Methods: Six to 8-week-old (C57BL/6) mice were placed in a controlled environment chamber at <20% humidity for 2 weeks, and a control group was bred in a normal environment. After these 2 weeks of dry eye (DE) induction, the mice were sacrificed and their LGs were collected. Lacrimal gland acinar cell organelle structures were observed with Transmission Electron Microscopy (TEM). TEM images were analyzed using the Image J program. Results: The size of the LGs of DE-induced mice decreased compared to those of normal mice. Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) staining was negative in DE-induced LGs. Under the TEM, the endoplasmic reticulum (ER) lumen was dilated and the lumen density increased in DE-induced mice. Additionally, cell organelles were surrounded by elongated ER lumens. The mitochondrial structure was destroyed and the number of vacuoles increased in the LGs of DE-induced mice. Conclusions: Structural changes of the LG developed due to DE induction. This suggests that the detailed mechanisms of these changes were ER stress and autophagy. However, there were no definite signs of apoptosis in the acinar cells of the DE-induced LGs. These findings are regarded as an important clue of the pathogenesis of non-Sjogren-type dry eye. J Korean Ophthalmol Soc 2014;55(8):1187-1194