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RISS 인기검색어
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- 저자 : 노정우(Jung Woo Noe) (검색결과 2 건)
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임인서(In Seo Lim),이건웅(Gun Young Lee),전상현(Sang Hyun Chun),김근호(Gheun Ho Kim),구자룡(Ja Ryong Goo),전노원(Rho Won Chun),채동완(Dong Wan Chae),김형직(Hyung Jik Kim),노정우(Jung Woo Noe) 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: Several factors have been raised as contributing to morbidity and mortality among patients with end-stage renal disease treated with hemodialysis. We performed this study to evaluate morbidity and the factors contributing to them in chronic hemodialysis patients. Methods. We analyzed retrospectively the demo- graphic chracteristics, regularly tested laboratory findings (CBC, blood chemistry, chest X-ray, ECG), hospitalization rate, and gross mortality among 84patients in the Hallym University Medical Center from February I, 1992 to January 31, 1994. Results: 1) Age distribution of the patients was 54±13(mean±SD) years (range, 23-79 years); 41 patients were men, 43patients were women: 30patients(35.7%) had diabetes. The duration of hemodialysis was 33±30 months (range, 3-125 months). 2) Forty four patieints(52.4%) required hospitalization during the 2-year follow-up period, and the most common causes of hospitalization were infection and cardiovascular disease. 3) A total of 1H(21.4%) of the patients died the 2-year follow-up period, and cardiovascular disease was commonest cause of death. 4) The factors such as advancing age, the duration of hemodialysis, and diabetes were neither associated with the risk hospitalization nor with that of death. The serum albumin concentration in dead patients(3.4±0.4g/d1) was lower(p<0.001) than that in survived patients(3.8±0.4g/dL). As compared with patients who had serum albumin concentration ≥3.5g/dL, patients with serum albumin concentration <3.5g/dL had increased odds ratio(8.14) for death. The serum creatinine concentration in dead patients (9.5+3.0g/dL) was lower(p<0.%! than that in survived patients(11.8±3.1g/dL). Conclusion: We concluded that regularly tested serum albumin concentration was the most important predictive factor for death in chronic hemodialysis patients.
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독성 표피 괴사융해증과 동반된 급속 진행성 사구체신염 1 예
김진철,최영희,김훈,구자룡,채동완,김근호,원남희,전노원,김형직,노정우,윤동석,구대원 대한내과학회 1998 대한내과학회지 Vol.54 No.5
RPGN is a catastrophic form of acute glomerulone-phritis characterized by an abrupt onset and rapid deterioration of renal function resulting in o1iguria within weeks or months, BPGN is seen in a variety of systemic disorders, including systemic lupus erythematosus, poly arteritis nodosa, Wegener's granulomatosis and subacute bacterial endocarditis. In addition, RPGN is seen in association with a variety of primary renal diseases such as poststreptacoccal glomrulonephritis, merrkranoproli-ferative glomerulonephritis, and IgA nephropathy, Good-pasture's syndrome. Toxic epidermal necrolysis (TEN) is a drug induced life threatening disease characterized by extensive epidermal detachment, necrosis, and mucosal erosion. TEN may involve liver, lung, intestine, and kidney. But renal involvement has seldom been reported. We report on a 63-year-old patient who developed a RPGN with a TEN. Renal biopsy showed pauci-immune crescentric glomerulonephritis and skin biopsy showed edematous change with extravasated erytkvcytes in upper dermis and several individually necrotic keratinocytes. ANCA and FANA test was negative. Our patient recovered renal function with steroid pulse therapy. The pathophysiology of TEN is unresolved but abnormal cytokine release (e.g., tumor necrosis factor) has been implicated in pathogenesis of TEN. Because various cytokines have direct toxic effect on kidney structure, the tubular and glomerular damage may be related to the cytokines involved in TEN. To our knowledge, this is the first documenting the presence of RPGN in patients with TEN. And there maybe some relations between PRGN and TEN which require further study. a
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