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- 저자 : 노수인(Su In Roh) (검색결과 19 건)
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최익수,노수인,곽철호,김상은,이찬우,Choi, Ik-Su,Roh, Su-In,Kwak, Cheol-Ho,Kim, Sang-Eun,Lee, Chan-Woo 대한족부족관절학회 2004 대한족부족관절학회지 Vol.8 No.1
1993년 3월부터 2003년 4월까지 성분도 병원 정형외과에서 족부 및 족관절 결절종의 진단으로 수술적 치료를 받은 17예의 경우에서 추적 관찰한 결과 다음의 결론을 얻을 수 있었다. 1. 위치는 족배측(Zone III)이 가장 많았고 수술 적응증은 동통 12예(70.6%)로 가장 많으며 외관상의 문제 4예 (23.5%), 신경학적 증상과 동통이 동반된 경우 1예 (5.9%)였다. 2. 족부 및 족관절의 결절종은 재발률이 비교적 높다. 따라서 술전에 환자에게 이에 대한 충분한 설명이 필요하다. 3. 족부 결절종의 수술은 관절낭의 연결 부위와 종괴의 완전한 적출이 재발을 낮추는데 도움이 될 수 있으나 해부학적인 특성상 어려움이 있어 시술전 정확한 종괴에 대한 평가와 수술시 결절종의 완전한 제거에 노력해야 할 것이다. Purpose: To evaluate the results of surgical treatment and relationship between the recurrence and characteristics of ganglions in foot and ankle. Materials and Methods: Seventeen cases of ganglions located in foot and ankle, excised at St. Benedict Hospital from Mar. 1993 to Apr. 2003, were included in the study. All of cases were analyzed retrospectively in terms of age, sex of the patients, location and size of the ganglion, symptom, operative method as well as recurrence rate were evaluated. The mean follow up was 1.8 years (11 months${\sim}$6.5 years). Results: The size of ganglion ranged from 0.5 cm to 5.0 cm with mean size of 2.5 cm. The most common area of ganglion was the dorsum of foot and pain was the primary chief complain. The recurrence was found in 4 cases (23.5%): 1 of them occurred among 8 cases the diameter of which was less than 2.5 cm and other 3 occurred among 9 cases larger than 2.5 cm. 12 cases were completely excised mass with no recurrence. But 5 cases were incompletely excised & ligated stalk of mass and 4 cases of them were recurred. A correlation was only observed between complete excision and low recurrence rate. Conclusion: Recurrence rate of ganglions in foot and ankle was high and the correlation was obtained between complete excision and low recurrence rate.
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이근일,노수인,최익수,Lee, Keun-Il,Roh, Su-In,Choi, Ik-Su 대한족부족관절학회 2001 대한족부족관절학회지 Vol.5 No.1
Purpose: To find out the priority of which procedure has had a better outcome both clinically and radiographically between the two groups, one is treated by primary repair and the other by modified Brostr$\ddot{o}$m's procedure, by comparing the postoperative ankle joint stability and the patient's degree of satisfaction. Material and methods: 16 cases were taken into consideration whose number of severed ligaments were at least two or more of the lateral collateral ligaments of the ankle, and also were confirmed intraoperatively. Among them, 8 cases were treated with primary repair and the other 8 cases were treated with primary repair and the other 8 cases by modified Brostr$\ddot{o}$m's procedure. Results: There was no distinguishable difference for the patient's degree of satisfaction between the two procedures above mentioned. In 3 cases treated with primary repair, functional instability was observed. In case of postoperative ankle joint stability, 7 of 8 cases treated by modified Brostr$\ddot{o}$m's procedure has revealed increased joint stability. And 3 of 8 cases which were treated by primary repair have showed postoperative residual instability. Conclusion: Actually, the severed ligament can not maintain its normal strength though several months has elapsed, and possible residual instability could be remained. Therefore, it can be expected that modified Brostr$\ddot{o}$m's procedure also would be a .good method in obtaining suitable ankle joint stability as well as subtalar joint stability because of its reinforcement using extensor retinaculum.
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골육종과 연골육종에서 Hypoxia-Inducible Factor-1과 Vascular Endothelial Growth Factor 유전자 발현
최익수(Ik Su Choi),노수인(Su In Roh),김재도(Jae Do Kim),장희경(Hee Kyung Chang),류형철(Hyeong Cheol Ryu) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.7
목적: 골육종과 연골육종에서 Vascular Endothelial Growth Factor (VEGF)와 Hypoxia-Inducible Factor-1 (HIF-l)의 발현을 조사하고, 병리 및 임상적 의의를 찾고자 한다. 대상 및 방법: 골육종 35예와 연골육종 9예의 조직에 단클론 항체를 이용한 면역 조직 화학 염색을 시행하였다. 병리학적 종양 악성도 분류는 WHO 분류법을 이용하였다. 결과: HIF-l은 35예의 골육종 중 19예(54.3%)에서, 연골육종에서는 9예 중 8예(88.9%)에서 발현되었다. 그런데 골육종에서만 HIF-l의 발현이 폐전이(p=0.020) 및 종양 악성도(p=0.016)와 유의한 상관성을 보였다. VEGF는 골육종 35예 중 24예(68.6%)에서, 연골육종 9예 중 6예(66.7%)에서 발현을 보였으며, VEGF의 발현도 골육종에서만 발현의 범위가 넓을수록 폐전이가 증가하는 상관관계를 보였다(p=0.024). 결론: HIF-l과 VEGF의 발현은 골육종과 연골육종 모두에서 높은 발현을 나타내어 두 종양의 발생과 진행에 중요한 역할을 할 것으로 사료되며, 특히 골육종에서 HIF-l의 발현은 높은 악성도와 폐전이를 예측할 수 있었고, 또한 VEGF의 발현 범위가 많은 골육종은 폐전이 빈도가 높다고 할 수 있겠다. 그러나 연골육종에서는 두 혈관 신생 인자의 예후 인자로서의 의미는 밝힐 수 없었다. Purpose: The purpose of this study is to investigate the impact of the vascular endothelial growth factor (VEGF) and the hypoxia-inducible factor-1 (HIF-1) expression on clinicopathologic factors in osteosarcomas and chondrosarcomas. Materials and Methods: Thirty-five osteosarcomas and 9 chondrosarcomas were assessed for HIF-1 and VEGF expressions with monoclonal antibodies using immunohistochemistry. The pathologic tumor grades are followed the WHO classification. Results: Nineteen out of 35 osteosarcomas (54.3%) and 8 out of 9 chondrosarcomas (88.9%) showed HIF-1 expressions. The HIF-1 expressions increased with the pulmonary metastasis (p=0.020) and the tumor grades (p=0.016) in only osteosarcomas. Twenty-four out of 35 osteosarcomas (68.6%) and 6 out of 9 chondrosarcomas (66.7%) showed VEGF expressions. The extents of VEGF expression in only osteosarcomas showed positive correlation with the pulmonary metastasis (p=0.024). Conclusion: The HIF-1 and VEGF appear to be an important role for the development and progression of these two tumors. The HIF-1 expression in osteosarcomas seems to be poor prognostic value including aggressive tumor grades and pulmonary metastasis. The extents of VEGF immunostaining might indicate the possibility of pulmonary metastasis in osteosarcomas. However, the two gene expressions could not indicate the significant prognostic value in chondrosarcomas.
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최갑승,곽철호,김상은,노수인,최익수,Choi, Kab-Seung,Kwak, Cheol-Ho,Kim, Sang-Eun,Roh, Su-In,Choi, Ik-Su 대한족부족관절학회 2004 대한족부족관절학회지 Vol.8 No.2
Purpose: To compare clinical characteristics of ganglions in hand & Foot. Materials and Methods: Seventeen cases of ganglions located in foot and fifty-five cases in hand. Excised from Mar.1988 to Apr.2003, were included in the study. The clinical characteristics and recurrence ratio were evaluated Results: The mean size of 2.2 cm in hand and 2.5 cm in foot. The most common area of ganglions are dorsum of foot and wrist. The cosmetic problem of palpable mass is the primary chief complaint of ganglions on hand and the pain is that of foot. The recurrence was found in 5 cases in hand and 4 cases in foot. The recurrence was related to incomplete excision of ganglion in foot and the large size of ganglion and incomplete excision of ganglion in hand. Conclusion: recurrence ratio in the cases of foot is higher than that of hand. The ganglions in foot and hand need to treated by meticulous surgical excision to prevent the recurrence.
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악성 근골격계 종양세서 CD117[c-kit]과 Her-2/neu 유전자 발현
정진규(Jin Gyu Jeong),최익수(Ik Su Choi),노수인(Su In Roh),곽철호(Cheol Ho Kwak),김상은(Sang Eun Kim),장희경(Hee Kyung Chang),김재도(Jae Do Kim) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.6
목적: 본 연구는 악성 근골격계 종양에서 c-kit (CD117) 유전자 단백질 발현과 Her-2/neu 발현의 양상을 조사하고, 임상 예후와 치료의 측면에서 발현의 의의를 연구하였다. 대상 및 방법: 파라핀 포매 조직이 보관된 32예의 악성 골종양(골 육종 23예, 연골 육종 9예)과 8예의 활막 육종을 대상으로 후향적 연구를 시행하였다. 유전자의 발현은 면역조직화학 염색방법을 이용하여 조사하였다. 결과: c-kit 발현은 골 육종에서 56.5% (13/23), 연골 육종에서 44.4% (4/9), 활막 육종에서 50.0% (4/8)의 발현율을 보였다. 23예의 골 육종에서 c-kit의 발현은 여자에서(p=0.044), 폐로의 전이가 있는 증례에서(p=0.044), 종양 세포의 악성도가 높을수록(p=0.023) 통계적으로 의미있는 높은 발현율을 보였다. Her-2/neu는 악성 골종양 32예와 활막 육종 8예 모두에서 발현되지 않았다. 결론: 악성 골종양과 활막 육종의 발생에 c-kit 유전자의 발현이 중요한 역할을 할 것으로 추정할 수 있으며, 특히 폐 전이된 골 육종에서 높은 발현율을 보였다. 이로써 이 종양들의 치료에 c-kit 유전자를 겨냥한 tyrosine kinase억제제의 사용을 고려할 수 있겠다. 그러나 Her-2/neu 유전지는 악성 골종양과 활막 육종 발생과 치료에 중요한 역할을 하는 것 같지 않다. Purpose: The aim of this study was to determine the prevalence of c-kit (CD117) and Her-2/neu expressions in malignant bone and soft tissue tumors and to identify a possible predictive role in patients with these malignancies. Materials and Methods: A retrospective study was conducted on 40 archival paraffin-embedded tissue specimens of patients with 32 malignant bone tumors (23 osteosarcomas, 9 chondrosarcomas) and 8 synovial sarcomas. The gene expressions levels were evaluated by immunohistochemistry. Results: C-kit expression was observed in 13 out of 23 osteosarcoma patients (56.5%), 4 out of 9 chon-drosarcoma patients (44.4%) and 4 of 8 synovial sarcoma patients (50.0%). In particular, the relationship between c-kit expression and gender (p=0.044), a pulmonary metastasis (p=0.044), and the tumor cell grade (p=0.023) in osteosarcoma were found to be statistically significant. On the other hand, Her-2/neu expression was not found in any of the 40 cases under study. Conclusion: These results suggest that the c-kit expression appears to play an important role in the development of a malignant bone tumor and synovial sarcoma. In particular, it should be noted that c-kit expression is found frequently in an osteosarcoma with a pulmonary metastasis. In this respect, the tyrosine kinase inhibitors can be considered to be significant in the treatment of a malignant bone tumor and a synovial sarcoma. However, Her-2/neu does not appear to play any significant role in these malignancies.
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