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류마티스 관절염 환자에서 조기에 병발한 2차성 유전분증에 의한 난치성 설사 1례
노성민 ( Sung Min Noh ),김채규 ( Chae Kyu Kim ),송용호 ( Yong Ho Song ),정자헌 ( Ja Hun Jung ),장현규 ( Hyun Kyu Chang ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.3
Amyloidosis is a disease that characterized by accumulation of an amorphous, proteinaceous materials in the various tissues and organs, but its origin is unknown. Recent clinical study showed that incidence of amyloidosis in rheumatoid arthritis was near 10% to 21%. Secondary amyloidosis is caused by accumulation of serum amyloid. A which is doing the acute phase behavior faster than C reactive protein. Symptoms of amyloidosis are various according to the involved organ. Gastrointestinal symptoms are obstruction, ulcer, malabsorption, and bleeding. Diarrhea is very intractable with the conventional antidiarrheal agent, the mechanism of that is infiltration of amyloid material in the intestinal myenteric plexus, sympathetic nerve and ganglion. We report a case of 65 years old woman with rheumatoid arthritis presented with abdominal pain, intractable diarrhea which was not controlled by antidiarrheal agents. Duration of arthritis is only 2 years. Immunohistochemical stain showed AA type which meant secondary form. We treated with Octreotide analogue and total parenteral nutrition for chronic diarrhea.
Latanoprost 사용 후 임상적 호전을 보인 백반증 3예
노성민 ( Seongmin Noh ),김태균 ( Tae Gyun Kim ),오상호 ( Sang Ho Oh ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.4
Vitiligo, which is characterized by depigmentation of skin and mucosa is a common skin disease, affecting 1-4 % of population. Although the pathogenesis is not clear, the basic defect lies in a decrease or absence of melanocytes. Vitiligo causes cosmetic disfiguration and exerts negative effects on quality of life. Phototherapy and topical agents such as corticosteroids, calcineurin inhibitors, and vitamin-D derivatives are basic treatment modalities. Recently, prostaglandin analogues have been reported to be effective on pigmentation of vitiligo lesions. We present three patients with periorbital vitiligo, who did not respond to established treatments such as tacrolimus and excimer laser, responding to application of latanoprost, a prostaglandin F2α analogue. (Korean J Dermatol 2010;48(4):350~353)
콤팩트 안테나 테스트 레인지용 경면수정 오프셋 복반사경 시스템의 설계
노성민(Sung-Min Noh),최학근(Hak-Keun Choi),임성빈(Sung-Bin Lim) 한국전자파학회 2008 한국전자파학회논문지 Vol.19 No.4
경면수정 오프셋 그레고리안 반사경 안테나는 고이득, 저 사이드로브 특성 때문에 위성 통신 시스템에 널리 사용되고 있다. 그러나 본 논문에서는 CATR(Compact Antenna Test Region)을 위한 반사경 시스템으로 설계하고 그 근접 전계 특성을 조사하였다. CATR은 시험 영역에 진폭과 위상 리플이 작고 교차 편파가 낮은 균일 평면파를 제공하여야 한다. 따라서 근접 전계를 개구면의 전력 분포, 급전 혼의 복사 패턴, 개구면과 시험 영역까지의 거리 변화에 따라 계산하여 나타냈다. 또한, 30 ㎓에서 동작하는 경면수정 오프셋 복반사경을 제작하고 근접전계를 측정하였다. 그 결과, 측정치와 계산치가 비슷하게 나타났다. 이로서 본 논문에서 설계된 경면수정 오프셋 복반사경은 콤팩트 안테나 테스트 레인지로 사용될 수 있을 것으로 생각된다. Gregorian offset dual-shaped reflector antennas have been widely used in the satellite communication systems for their high gain and low sidelobe characteristics. However, in this paper, it is designed as the CATR(Compact Antenna Test Range) reflector system, and its near-field characteristics are investigated. The CATR facility needs to provide an uniform plane wave with the minimum amplitude and phase ripple and the low cross polarization to the test region. Therefore, the reflector near-field patterns are calculated and presented with the variations of the aperture power distribution, the feed horn pattern, and the distance from the aperture to the test zone. Also, the offset dual-shaped reflector is fabricated at 30 ㎓, and its near-field patterns are measured. The measured results are in good agreement with the calculated results. From theses results, we confirm that the designed offset dual-shaped reflector can be used as the reflector system for the compact antenna test range.
아토피피부염 환자에서 APDDR-0801 보습 제품의 병용을 통한 스테로이드 외용제제의 사용 절감 효능
노성민 ( Seong Min Noh ),정진영 ( Jin Young Jung ),박원석 ( Won Seok Park ),고현주 ( Hyun Ju Koh ),이광훈 ( Kwang Hoon Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.3
Background: Defective skin barrier function is a well recognized feature in atopic dermatitis (AD) and causes symptoms such as xerosis, pruritus and erythematous lesions. Since moisturizers can strengthen a defective skin barrier and reduce the usage of corticosteroid cream, the choice of moisturizer is very significant for AD patients. Objective: This study was done to compare the steroid-sparing effects of a ceramide-containing moisturizer, APDDR-0801, with a control moisturizer without ceramide, for relieving symptoms associated with AD. Methods: A randomized, controlled, double-blinded 6-week study was conducted. Patients with mild to moderate AD topically applied APDDR-0801 or the control moisturizer on the whole body for 6 weeks. They also applied corticosteroid cream (Zemaderm(R)) on the lesion twice daily for 6 weeks. The amount of corticosteroid used was measured by weighing the tubes. Disease severity was evaluated by eczema severity, area index (EASI), and investigator global assessment (IGA). Transepidermal water loss (TEWL) and skin capacitance were also measured. Results: Of the 40 patients enrolled, 32 completed the protocol. The mean age was (12.95±1.92) and the average baseline EASI score was (10.45±1.17). EASI score, IGA, TEWL and skin capacitance improved in both groups at 3 weeks and 6 weeks. Compared to the control group, the amount of steroid cream used at 3 weeks and 6 weeks decreased by 0.14 g (-18.78%) and 0.76 g (-7.46%), respectively, in the test group. The difference was larger in patients with moderate AD. The consumption of steroids was lower in the test group at 3 weeks [2.65 g (-34.64%)] and at 6 weeks [2.60 g (-19.38%)], respectively. Conclusion: The moisturizer APDDR-0801 (Atobarrier cream(R)) which contains physiologic lipid granules including ceramide, has superior steroid-sparing effects than moisturizers without ceramide. (Korean J Dermatol 2011;49(3): 227∼233)
외인성 아토피피부염과 내인성 아토피피부염 환자의 말초혈액 단핵세포와 피부 병변에서 IL-3와 FcεRI 발현의 차이
김산 ( Shan Jin ),노성민 ( Seong Min Noh ),배병기 ( Byung Gi Bae ),박창욱 ( Chang Ook Park ),이광훈 ( Kwang Hoon Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.6
Background: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed ``intrinsic`` AD (IAD) as compared to its counterpart ``extrinsic`` AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. Objective: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. Methods: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcεRI and FcεRII from the PBMCs and lesional skin of patients with IAD and EAD. Results: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcεRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. Conclusion: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcεRI which was previously shown to be highly expressed in EAD patients. (Korean J Dermatol 2011;49(6):491∼498)
Chloroquine 내성 유입 말라리아 14 예에 대한 Halofantrine 의 치료효과
조현장(Hyun Jang Cho),노성민(Sung Min Noh),이상도(Sang Do Lee),부철수(Cheol Su Poo),김성일(Sung Il Kim),김두형(Du Hyeong Kim),김승영(Seung Young Kim),박병엽(Byeung Yeub Park) 대한내과학회 1997 대한내과학회지 Vol.53 No.4
N/A Objectives: The prevalence of malaria is increasing in recent years and also multidrug resistant malaria is increasing around the world and there is an increasing concern about imported malaria in nonendemic areas. Now many drugs are tried to find out effect on multidrug resistant malaria. We performed this study to investigate the thrapeutic effect of halofantrine in the treatment of chloroquine resistant imported malaria. Methods: From Feb. 1992 to May 1995, we experienced 35 patients infected with malaria and treated 14 patients among 35 patients with halofantrine. Results: 1) All 14 patients were sailor with a mean age of 39.4 years and infected with malaria. 2) The majority of patients were infected with malaria at Africa. 3) 10 patients were infected with Plasmodium falciparum and the remainder were undetermined. 4) In the 11 cases of chloroquine resistant malaria treated with quinine plus tetracycline combination therapy or Fansidar, 4 cases could not be tolerable due to side effects and resistance to the therapy, we substituted halofantrine for above regimens. 5) In the 10 cases, treated after May 1994, halofantrine was the first choice of treatment because they were the cases of malaria infected in the mid-Africa where the prevalence of chloroquine resistant malaria is high. 6) With halofantrine, all 14 cases were treated with minimal side effects suc4 as nausea, vomiting, anorexia, abdominal pain and fatigue. Conclusion: We think halofantrine is a simple and effective regimen against chloroquine resistant malaria and consider this agent as an alternative therapeutic regimen on chloroquine resistant malaria.