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노명주,한미아,박종,류소연 한국병원약사회 2017 병원약사회지 Vol.34 No.4
Background : When nurses do not perform injections properly, it can cause fatal complications for patients depending upon the nature of the drug. The aim of this study was to investigate nurses’ performances related to infection control during injection protocols and related procedures. Methods : The study subjects were 391 nurses working in one of 3 general hospitals in“ D”and“ G” metropolitan cities. The data were collected using a self-report questionnaire data which was composed of general characteristics, work-related characteristics, health-related characteristics, infection- related characteristics, and performance of infection control during injections. The collected data were analyzed using the Statistical Package for Social Sciences (SPSS) software. Statistical analyses included descriptive analysis, t-tests, and analyses of variance (ANOVAs). A multiple linear regression was used to investigate the factors associated with the performance of infection control during injections after controlling for several covariates. Results : The overall performance score of infection control during injections was 4.56±0.38. The performance score of hand hygiene and infection control during administration were 4.45±0.47 and 4.62±0.38, respectively. The performance of infection control during injection was related to age, working unit, perceived importance of infection control for injection use, and experience of infection control education in a multiple linear regression analysis. Conclusion : The performance of infection control for injection was significantly associated with the nurses’experiences with infection control education. Therefore, in order to improve the performance of infection control during injections, it is necessary to develop a training program and continuously evaluate and monitor the training according to the changes in the infection control instruction.
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요골동맥을 이용한 관상동맥 조영술시 Tiger Catheter의 임상적 유용성
조용찬,반재성,김종태,노명주,정안덕,조상철,강원유,황선호,김완,김원 대한심장학회 2009 Korean Circulation Journal Vol.39 No.1
The most important complications of the transradial coronary approach during coronary artery angiography are occlusion of the radial artery and arterial spasm which are known to be influenced by catheter size, procedure time, and repeat procedures. The purpose of this study was to evaluate the usefulness of a Tiger catheter (TC) which was designed for the selection of right and left coronary artery ostia simultaneously, compared with the Judgkins catheter (JC) during transradial coronary angiography (CAG). Subjects and Methods: One hundred forty-four patients were randomized between groups who underwent CAG with a standard 5F JC or a TC. The procedure time and vasospasm of the radial artery, which were expressed as stenosis of the vessel diameter, were examined using a transradial approach. Four parts of the blood vessel diameter were measured at baseline, during injection of the vasodilator, and at the end of the procedure. Results: There were no significant differences in gender, age, weight, or other cardiovascular risk factors between the two groups of patients. CAG was successfully performed using a TC in 89% of the patients. A TC was associated with a significantly shorter total procedure time than the JC for diagnostic CAG (451±120.4 vs. 542.3±180.5 sec, p=0.001), respectively. There was no significant difference in stenosis between the two groups (36% vs. 41% in TC and JC, respectively, p= 0.358). There were no angiographic or clinical complications in each group. Conclusion: This study showed that the TC is associated with decreased total CAG procedure time compared with the JC. 배경 및 목적 시술 후 중요한 합병증으로 요골동맥의 폐쇄가 보고되고 있으며, 이는 카테터의 크기, 시술시간, 요골동맥의 반복시 술이 영향을 미치는 것으로 알려져 있다. TC는 좌우 관상 동맥을 하나의 카테터로 조영할 수 있게 도안되었다. 본 연 구는 진단적 관상동맥 조영술시 기존의 2개의 JC와 TC의 단 독 사용시 시술시간 및 요골동맥의 혈관확장과 연축의 유무 에 미치는 영향을 비교, 분석하고자 하였다. 방 법 요골동맥을 이용하여 관상동맥 조영술을 시행한 환자 144 명을 JC와 TC를 사용한 두 군으로 나누었다. 도관의 크기는 5 Fr로 일정하게 하였으며, 요골동맥의 연축여부는 요골동맥 의 근위부와 중간분절에서 총 4곳의 혈관 직경을 혈관확장 제 투여후와 검사 종료시 각각 측정하여 비교하였다. 시술시 간은 요골동맥을 통하여 Judgkins 카테터 또는 Tiger 카테 터 삽입 시점부터 관상동맥 조영술 후 도관 제거 바로 전까지 의 시간으로 정의하였다. 일차종결점은 시술시간으로 하였다. 결 과 양 군 간의 성별, 나이, 신장, 체중, 체질량지수, 관상동맥질 환의 위험인자의 차이는 없었다. Tiger 도자 사용시 약 89% 의 환자에서 좌우 관상동맥 조영술이 가능하였다. 각 군간 의 시술시간은 TC군이 451.0±120.4초, JC군이 542.3± 180.5초로서 TC군에서 JC군과 비교하여 유의하게 짧은 시 술시간을 보였다 (p=0.01). 또한 TC군이 시술종료 때까지 혈관확장 및 연축발생 비율도 양호한 경향을 보였지만, 유 Yong Chan Cho, et al.·15 의한 차이는 없었다. 결 론 TC를 사용한 요골동맥 관상동맥 조영술시 시술시간을 감 소시킬 수 있었으며, 양호한 성공률을 보였다.
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이재철,Periasamy Anbu,김원호,노명주,이수진,서정우,허병기 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.5
The Δ9-elongase isolated from Thraustochytrium aureum, which contains a high level of polyunsaturated fatty acids (PU-FAs), was demonstrated to be associated with the synthesis of C20 PUFAs. The TaELO gene contains a 825 bp ORF that encodes a protein of 274 amino acids that shares a high similarity with other PUFA elongases. The expression of the TaELO gene in Pichia pastoris resulted in the elongation of linoleic acid (LA, C18:2; n-6) and α-linolenic acid (ALA, C18:3; n-3) to ei-cosadienoic acid (EDA, C20:2; n-6) and eicosatrienoic acid (ETrA, C20:3; n-3), respectively. The endogenous conversion rate of LA and ALA to EDA and ETrA was 32.68 and 38.57%, respectively. In addition, TaELO was also able to synthesize eicosenoic acid (C20:1; n-9) from oleic acid (OA, C18:1; n-9), even though the conversion level was low (2.81%). Further-more, TaELO was able to carry out the Δ6-elongation of γ-linolenic acid (GLA, C18:3; n-6) to dihomo-γ-linolenic acid (DGLA, C20:3; n-6) and Δ5-elongation of eicosapentaenoic acid (EPA, C20:5; n-3) to docosapentaenoic acid (DPA, C22:5; n-3). The conversion rate of GLA to DGLA and EPA to DPA were 93 and 28.36%, respectively. The TaELO protein was confirmed to have multifunctional activities, such as Δ9, Δ6, and Δ5-elongations as well as the elongation of monounsaturated fatty acid.
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