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김흥덕,정경훈,정운주,김상룡 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.4
Parkinson’s disease (PD) is a chronic and progressive movement disorder, resulting from the degeneration of the nigrostriatal dopaminergic (DA) pathway. The cause of DA neuronal loss in PD is still unclear; however, accumulating evidence suggests that treatment with certain flavonoids can induce neuroprotective properties, such as activation of mammalian target of rapamycin complex 1 (mTORC1) and anti-inflammatory activities in animal models of PD. The bioflavonoid myricitrin is well known for its anti-inflammatory and antioxidant properties. However, it is unclear whether systemic treatment with myricitrin can protect neurons against neurotoxin-induced DA degeneration in vivo via the preservation of tyrosine hydroxylase (TH) activity and the induction of mTORC1 activation. Our results found no significant neuroprotective effect of 30 mg/kg myricitrin on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in the substantia nigra (SN) of mice. However, myricitrin treatment with 60 mg/kg protected DA neurons against 6-OHDA-induced neurotoxicity. Moreover, myricitrin treatment preserved TH enzyme activity and mTORC1 activation in nigral DA neurons in the SN of 6-OHDAtreated mice, and its treatment suppressed an increase in tumor necrosis factor-α expression in activated microglia. These results suggest that myricitrin may have neuroprotective properties linked to mTORC1 activation, preservation of TH enzyme activity, and anti-neuroinflammation for preventing DA neuronal degeneration in vivo.
김정숙,김흥덕,박정림,Kim, Jeoung-Sook,Kim, Hung-Deuk,Pack, Jung-Rim 대한치과기공학회 2005 대한치과기공학회지 Vol.27 No.1
The market of dental materials industry in Korea will over 10 bilians $. If think concern of world market, we can know the possibility of market growth. In Korea, the technique of dental materials industry is low status. Then, special items income advanced countries. But advanced countries had been developed dental materials industry into high beneficial. Otherwise, Daegu Kyungbuk have several good points in dental materials industry. 1st, national dentisty university and three dental lab. college supplies abilitable human resources. 2nd, the possibility of support on basic industrial technology. Finally, the possibility of selection & attraction from many dental company. Then if Daegu Kyungbuk would be select & supported of dental materials Industrial special region, it can be think that will empower local economy, further national constitutional power. So we propose following three points, 1st. the deeper study on righteous of Daegu Kyungbuk dental materials industrial specialization. 2nd. investment on R & D of the region dental materials industrial. final, the support of venture circle.
정경훈,전민태,김흥덕,정운주,장민철,주진우,양승준,최일윤,최명숙,김상룡 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4
This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson’s disease (PD). 1-Methyl-4-phenylpyridinium (MPP+) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP+ -treated rats. In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.