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주혜영 ( Hye Young Ju ),김혜성 ( Hye Seung Kim ),임숙희 ( Sook Hee Lim ),이승동 ( Seung Dong Lee ),강훈 ( Hoon Kang ),김형옥 ( Hyung Ok Kim ),박영민 ( Young Min Park ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.9
Background: A recent survey on dermatology outpatients, which assessed their knowledge and behavior for topical steroid use, showed that topical steroids were often used without sufficient information or guidelines. Objective: Our study aimed to evaluate the general pattern of which dermatologists prescribe topical steroids, the prevalence of topical steroid phobia among the dermatology outpatients and the way dermatologists managed such patients. Methods: 236 dermatologists, including those in private clinics and those in the secondary and tertiary hospitals, were asked via mail or e-mail to fill in a questionnaire on their topical steroid prescription. Results: About sixty percent of the total respondents answered that they prescribed topical steroid to more than half of their outpatients, with excluding those patients who came to the office for cosmetic purposes. Most respondents informed their patients about their prescription of topical steroids (85.61%), they explained the mechanism of its action and the clinical effects (65%), the potency and duration of application (70%), and the side effects (82%). But most respondents forgot or did not tell their patients about their steroid formulation (46%), the optimal amount to apply (74%) and the means and duration of optimal storage (82%). 45% of the respondents assumed that more than half of the outpatients to have topical steroid phobia. Yet 80% of the respondents replied that less than 10% of their outpatients had experienced side effects of topical steroids. 73% of the respondents in private clinics and 62% in secondary and tertiary hospitals were influenced by the patients` negative attitude on topical steroid prescription. Conclusion: The results show that the information on topical steroids, in terms of formulation, the optimal amounts to apply and the means and duration of optimal storage, were not sufficiently provided by dermatologists. The topical steroid phobia of patients has been exaggerated despite the low incidence of side effects. (Korean J Dermatol 2009;47(9):1004∼1011)
논문 : IG-11 원자로용 흑연의 열방사 특성에 미치는 표면 거칠기의 영향
노재승 ( Jae Seung Roh ),서승국 ( Seung Kuk Seo ),김석환 ( Suk Hwan Kim ),지세환 ( Se Hwan Chi ),김응선 ( Eung Seon Kim ),김혜성 ( Hye Sung Kim ) 대한금속재료학회(구 대한금속학회) 2011 대한금속·재료학회지 Vol.49 No.7
This paper reports the relationship between the surface roughness and thermal emissivity of graphite (IG-11) in nuclear reactors. The roughness was controlled by changing the oxidization time, resulting in 0, 6, and 11% losses of mass. The levels of roughness were 0.40, 0.72 and 1.09㎛ for the weight loss of 0, 6 and 11%, respectively. The binders and graphite fillers were found to have sequentially oxidized with a higher thermal emission for the highly oxidized sample, but with a lower emission when measured at a higher temperature. Our study suggests a method for predicting the thermal emission rate of graphite in a nuclear reactor based on roughness measurement.
피부전이를 동반한 외투막세포(Mantle Cell) 림프종 1예
주혜영 ( Hye Young Ju ),김혜성 ( Hye Seung Kim ),이준영 ( Jun Young Lee ),김형옥 ( Hyung Ok Kim ),박영민 ( Young Min Park ) 大韓皮膚科學會 2010 大韓皮膚科學會誌 Vol.48 No.2
Mantle cell lymphoma is a malignant lymphoma derived from a subset of B-cells that are localized in the mantle area of the lymphoid follicle. Extranodal involvement is frequent, and especially in the bone marrow, spleen, gastrointestinal tract and Waldeyer`s ring, but skin is rarely affected. A 47-year-old male presented with a 40 day history a nodule on the abdomen on the abdomen. The histopathologic examination showed numerous atypical, small to medium sized lymphoid cells in the entire dermis. Immunohistochemically, the tumor cells were positive for CD20, CD5, CD79a and cyclin D. Our patient showed complete disappearance of his skin lesions and lymphadenopathy after combination chemotherapy. (Korean J Dermatol 2010;48(2):158∼160)
열성경련과 열성경련플러스(GEFS+)에서 인터루킨-1β 촉진자의 다형성
정승연(Seung Yun Chung),박양준(Yang Joon Park),김영훈(Young HOon Kim),이인구(In Goo Lee),황경태(Kyung Tai Whang),이준성(Joon Sung Lee),김혜성(Hye Sung Kim),이권행(Kweon Haeng Lee),임성빈(Sung Vin Yim) 대한소아신경학회 2006 대한소아신경학회지 Vol.14 No.1
목 적: 최근에 IL-1β 유전자 촉진자 부위의 위치 -511(IL1B -511)에서 단일염기다형성이 발견되었다. 그러나 열성경련에서 IL-1β 유전자 촉진자의 다형성 이 관여하는지에 대해서는 상반된 보고가 있다. 본 연구에서는 IL-1β 유전자의 위치 -31과 -511에 촉진자 부위의 기능과 관련이 있는 단일뉴클레오티드 염기 C/T대립 다형성이 열성경련의 감수성과 연관이 있는지 여부를 알기 위하여 단순열성경련, GEFS+ 및 건강한 대조군에서 IL1B-31과 -511 다형성의 빈도를 조사하였다. 방 법: 가톨릭대학교 의정부성모병원 및 성모자애병원 병원 소아과에서 진단받은 열성경련 환아 72명, GEFS+ 환아 23명 및 건강한 대조군 174명, 총 269명을 대상으로 하였다. IL1B -31 C/T 유전형과 IL1B -511 C/T 유전형은 PCR-제한절 편길이다형성으로 결정하였다. 결 과 : IL1B -31 유전자에 대한 유전형 분포와 대립유전자 빈도는 통계학적으로 유의한 차이가 없었다. C동형접합자, C/T이형접합자 및 T동형접합자의 분포는 열성경련 환아군에서 22.2%, 50.0% 및 27.8%이었고, GEFS+ 환아군에서 21.7%, 43.5% 및 34.8%이었으며, 건강한 대조군에서 27.6%, 49.3% 및 24.1%이었다. IL1B -511 유전자에 대한 유전형 분포와 대립유전자 빈도는 통계학적으로 유의한 차이가 없었다. C동형접합자, C/T이형접합자 및 T동형접합자의 분포는 열성경련 환아군에서 23.6%, 47.2% 및 29.2%이었고, GEFS+ 환아군에서 26.1%, 39.1% 및 34.8%이었으며, 건강한 대조군에서 27.6%, 49.3% 및 24.1%이었다. 결 론: 이러한 결과는 IL1B -31과 -511 유전자가 한국인 열성경련의 유력한 유전적 표지는 아니라는 것을 보여주는 것이다. Purpose : Studies gave conflicting results as to the association between febrile seizures(FSs) and IL1B promoter polymorphisms. In the present study, to determine whether or not the function-related two single nucleotide base C/T biallelic polymorphisms in the promoter region at positions -31 and -511 of the IL1B gene are associated with susceptibility to FSs, the frequencies of the polymorphisms were investigated in children with FSs and GEFS+, and normal control subjects. Methods : 72 FSs, 23 GEFS+ and 174 healthy control subjects were selected throughout a collaborative study of Catholic Child Neurology Research Group. IL1B promoter -31 C/T and -511 C/T genotyping was performed by means of PCR-restriction fragment length polymorphism. Results : The distribution of IL1B -31 genotypes and the frequencies of allele in children with FSs and GEFS+, nd healthy control subjects were not significantly different. The distributions of IL1B -31 genotypes(CC, CT, TT) are 22.2%, 50%, and 27.8% in children with FSs, 21.7%, 43.5% and 34.8% in children with GEFS+, and 27.6%, 49.3% and 24.1% in healthy control subjects. The distribution of IL1B -511 genotypes and the frequencies of allele in children with FSs and GEFS+, and healthy control subjects were not significantly different. The distributions of IL1B -511 genotypes(CC, CT, TT) are 23.6%, 47.2%, and 29.2% in children with FSs, 26.1%, 39.1% and 34.8% in children with GEFS+, and 27.6%, 49.3% and 24.1% in healthy control subjects. Concl usi on : Theses data suggest that genomic variations of IL1B promoter might not be one of the susceptibility factors for FSs in the Korean population.
뇌졸중환자에서 개인 맞춤형 다중자극 뇌신경자극기의 안전성 및 마비측 상지기능 개선효과에 관한 연구
조윤주(Yun-Ju Jo),김혜성(Hye-Sung Kim),강승록(Seung-Rok Kang),김다솔(Da-Sol Kim),김기욱(Gi-Wook Kim),고명환(Myoung-Hwann Ko) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
The purpose of this study is to investigate the effect of improving upper extremity function in the treatment of stroke patients using an artificial intelligence-based personalized multi-mortal cranial nerve stimulation treatment device that can provide a neural feedback technique to control brain stimulation treatment by measuring real-time changes during treatment. The 96 subjects were randomly divided into 3 groups. Group 1 received sham tDCS and occupational therapy. Group 2 received real tDCS and occupational therapy. Group 3 receives treatment using a personalized multi-modal cranial nerve stimulation therapy device. The tDCS stimulation intensity is 2 mA, 30 minutes a day, 3 times a week, for a total of 8 weeks, the lesion side primary motor area is stimulated. The following evaluations are performed before treatment, immediately after 8 weeks of treatment, and 4 weeks after the end of treatment in order to investigate the safety and improvement of the paralyzed upper extremity function according to the treatment. Fugl-Meyer Upper Motor Score, Manual muscle test, Range of motion, Korean version modified bathel index, Modified Ashworth Scale, Motor evoked potential, K-MMSE, K-MOCA.
언어치료 솔루션의 재가치료 활용을 위한 사용적합성평가 및 만족도 조사 연구
조윤주(Yun-Ju Jo),김혜성(Hye-Seong Kim),강승록(Seung-Rok Kang),김기욱,고명환(Myoung-Hwan Ko) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
The purpose of this study is to investigate a usability assessment to evaluate the safety and satisfaction of ‘Smart speech’, a speech therapy solution program so that speech therapy can be easily performed at home. Smart speech program consists of software, laptop and microphone, and includes 59 training games for oral exercise, breathing training and voice training. We evaluated whether the events occurring in the process of using the product were properly performed when the product manual was provided to 5 ordinary people without experience in speech rehabilitation and allowed to use easily. In addition, we investigated the survey of safety and satisfaction in the product. As a result of the experiment, it showed a 100% success rate in 23 tasks with 3 scenarios. In addition, in the satisfaction survey result, we found that more than 80% of the 15 items were satisfied with the convenience of use, treatment utilization, and overall satisfaction with the program. In the future, we thought that a speech therapy programs could be used as basic data to develop speech therapy medical devices for the speech-impaired using the results.
언어치료 솔루션의 재가치료 활용을 위한 사용적합성평가 및 만족도 조사 연구
조윤주(Yun-Ju Jo),김혜성(Hye-Seong Kim),강승록(Seung-Rok Kang),김기욱,고명환(Myoung-Hwan Ko) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
The purpose of this study is to investigate a usability assessment to evaluate the safety and satisfaction of ‘Smart speech’, a speech therapy solution program so that speech therapy can be easily performed at home. Smart speech program consists of software, laptop and microphone, and includes 59 training games for oral exercise, breathing training and voice training. We evaluated whether the events occurring in the process of using the product were properly performed when the product manual was provided to 5 ordinary people without experience in speech rehabilitation and allowed to use easily. In addition, we investigated the survey of safety and satisfaction in the product. As a result of the experiment, it showed a 100% success rate in 23 tasks with 3 scenarios. In addition, in the satisfaction survey result, we found that more than 80% of the 15 items were satisfied with the convenience of use, treatment utilization, and overall satisfaction with the program. In the future, we thought that a speech therapy programs could be used as basic data to develop speech therapy medical devices for the speech-impaired using the results.