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혈청학석조사를 통한 한국 양돈장에서의Mycoplasma hyopneumonae 감염 시점의 분석
김혜권,김은미,문형준,김태융,임종성,이양호,박봉균,Kim, Hye-kwon,Kim, Eun-mi,Moon, Hyoung-joon,Kim, Tae-yung,Lim, Jong-sung,Lee, Yang-ho,Park, Bong-kyun 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4
Blood samples from 622 pigs of 44 farms which were sero-positive to Mycoplasma hyopneumoniae (M. hyo) by ELISA method were collected from May 2003 to July 2004. And they were divided into 2 categories : M. hyo-vaccinated group (7 swine farms) and M. hyo-non-vaccinated group (37 swine farms). Then, each swine farm was analysed by sero-positive percentage per weeks of age. It was observed that the sero-positive percentage to M. hyo is directly proportional to weeks of age in the 44 swine farms that were selected. This meant that there has been a chronic infection of M. hyo in Korean swine herds and control of M. hyo infection did not have worked efficiently. In 7 M. hyo-vaccinated swine farms, there were no reliable patterns between sero-positive percentage to M. hyo and weeks of age. Although the swine farms have been used M. hyo vaccine, they had only little sero-positive percentage that was less than 50% at 6 to 11 weeks of age. This means a present vaccination program does not induce sufficiently a seroconversion expected. In 37 M. hyo-non-vaccinated swine farms, it was observed that sero-positive percentage was higher at above 15 weeks of age. This result showed that infection of M. hyo occurred commonly at between 7 and 12 weeks of age, at which pigs moved to the growing house. Because a risk of natural infection is severe at growing stage as well as nursery stage, it suggested that M. hyo vaccination at several weeks prior to the growing stage will give efficient effect to control the enzootic pneumonia.
Recent outbreaks of highly pathogenic avian influenza viruses in South Korea
김혜권,정대균,윤선우 대한백신학회 2017 Clinical and Experimental Vaccine Research Vol.6 No.2
Outbreaks of H5 highly pathogenic avian influenza viruses (HPAIVs) have caused economic loss for the poultry industry and posed a threat to public health. In South Korea, novel reassortants of HPAIVs such as H5N6 and H5N8 had been circulating in poultry. Here, we will discuss the identity of recent novel reassortants of Korean H5 HPAIVs and the recent advances in vaccine development, which will be useful for controlling HPAIV transmission in poultry and for effectively preventing future epidemics and pandemics.
김혜권,유광수,Thi My Le Huynh,문형준,Van Giap Nguyen,박봉균 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.2
There are high levels of co-incidence of porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in porcine tissue. This study established a duplex nested reverse transcriptase polymerase chain reaction (RT-PCR) method that targets the genomic RNA of type 2 PRRSV and the mRNA of PCV2 in infected tissues. The method amplified discriminative bands of 347 bp and 265 bp specific for type 2 PRRSV and PCV2, respectively. The limits of detection of the duplex nested RT-PCR were 101.5 TCID50/mL for type 2 PRRSV and 102 infected cells/mL for PCV2. The kappa statistic, which measures agreement between methods, was 0.867, indicating a good level of agreement. This RNA-based duplex RT-PCR approach can be another way to detect type 2 PRRSV and PCV2 simultaneously and with improved convenience.
김혜권,김정기,송호영,최정아,심병식,강보규,문형준,염민주,김상현,송대섭,송만기 한국미생물학회 2014 The journal of microbiology Vol.52 No.9
Sublingual (SL) administration of influenza vaccine would benon-invasive and effective way to give human populationsprotective immunity against the virus, especially when pandemicinfluenza outbreaks. In this study, the efficacy of pandemicinfluenza virus-based subunit vaccines was tested aftersublingual (SL) adjuvant administration in pigs. Eight specificpathogen-free Yucatan pigs were divided into 4 groups: nonvaccinatedbut challenged (A) and vaccinated and challenged(B, C, and D). The vaccinated groups were subdivided by vaccinetype and inoculation route: SL subunit vaccine (hemagglutininantigen 1 [HA1] + wild-type cholera toxin [wtCT],B); IM subunit vaccine (HA1 + aluminum hydroxide, C); andIM inactivated vaccine (+ aluminum hydroxide, D). The vaccineswere administered twice at a 2-week interval. All pigswere challenged with pandemic influenza virus (A/swine/GCVP-KS01/2009 [H1N1]) and monitored for clinical signs,serology, viral shedding, and histopathology. After vaccination,hemagglutination inhibition titre was higher in groupD (320) than in the other vaccinated groups (40–80) at thetime of challenge. The mobility and feed intake were reducedin group C. Both viral shedding and histopathological lesionswere reduced in groups B and D. Although this study haslimitation due to the limited number of pigs (2 pigs per agroup), the preliminary data in this study provided the protectivepotential of SL administration of bacteria-expressedpandemic H1N1 influenza vaccine in pigs. There should beadditional animal studies about effective adjuvant systemand vaccine types for the use of SL influenza vaccination.
김혜권,Jeong Sun Yang,문형준,Seong Jun Park,Yuzi Luo,송대섭,Dae Sub Song,강보규,Soo Kyung Ann,Chan Hyuk Jun,박봉균 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.2
The 23 open reading frame (ORF) 5 sequences of Korean type II porcine reproductive and respiratory syndrome virus (PRRSV) were collected from viremic sera from the (modified live vaccine) MLV-vaccinating and non-vaccinating farms from 2007 to 2008. The samples were phylogenetically analyzed with previous ORF5 sequences, including type I Korean PRRSV, and previously reported or collected sequences from 1997 to 2008. A MN184-like subgroup of type II Korean PRRSV was newly identified in the viremic sera collected from 2007 to 2008. And of the type I PRRSVs, one subgroup had 87.2∼88.9% similarity with the Lelystad virus, showing a close relationship with the 27∼2003 strain of Spain. The maximum parsimony tree of type II PRRSV from 1997 to 2008 showed that they had evolved to four lineages, subgroups 1, 2, 3 and 4. Most of the recently collected type II PRRSVs belonged to subgroup 4 (48%). The region of three B-cell epitopes and two T-cell epitopes of ORF5 amino acids sequences was considerably different from the MLV in subgroups 3 and 4. In conclusion, the existence of type I PRRSV, which was genetically different from Lelystad virus (Prototype of type I PRRSV), and heterologous type II PRRSVs of viremic pigs detected even in the MLV-vaccinating farms indicated the need for new vaccine approaches for the control of PRRSV in Korea.
우리나라 양돈장에서 Mycoplasma hyopneumoniae 유병율 조사
김혜권,김태융,임종성,이양호,박봉균,Kim, Hye-kwon,Kim, Tae-yung,Lim, Jong-sung,Lee, Yang-ho,Park, Bong-kyun 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.1
Serum samples of 1,175 pigs from 148 Korean swine farms not using Mycoplasma hyopneumoniae (M. hyo) vaccines were collected for seroepidemiological study of M. hyo infection by indirect ELISA method. Informations of each farm were provided about province where the farm was located and season when blood samples were collected. Then, the selected farms were divided into farm units which had 5 serum samples according to production stages : sow, suckling piglet (<30 days old), nursery pig (30-70 days old), and growing pig (>70 days old). Seroprevalence of M. hyo infection according to production stages, province, and season was investigated by using ELISA-positve rate of the selected samples for each study. This study showed that 85.34% (78.94-91.78%, 95% CI) of farms were positive to M. hyo infection and 34.81% (32.09-37.53%, 95% CI) among pigs were sero-positive to M. hyo infection in Korean swine farms. In the study of seroprevalence by production stage, most farms had sows and growing pigs which were sero-positive to M. hyo infection (sow: 83.05%, growing pigs: 87.72%) and most pigs seemed to be naturally infected by M. hyo at 8-10 weeks of age. Also, M. hyo infection showed seasonal pattern that most pigs were infected in late fall to early winter. However, in the study of seroprevalence by province, there was no significant correlation between province and M. hyo sero-positive rate.
콘크리트 압출 노즐의 요구사항 분석을 위한 비정형 패널 제작 실험
김혜권 ( Kim Hye-kwon ),윤종영 ( Youn Jong-young ),이동훈 ( Lee Donghoon ) 한국건축시공학회 2023 한국건축시공학회 학술발표대회 논문집 Vol.23 No.1
With the development of technology, interest in the implementation of free-form buildings is increasing, and research on producing free-form panels is being conducted accordingly. Since free-form buildings are curved and consist of geometric shapes, there are many problems with the production technology of free-form panels that implement them. Due to the inability to reuse molds, the cost of disposal of construction waste and waste of manpower for assembly increase the construction period and construction cost. To improve these limitations, a 3D printed concrete nozzle for FCP production was developed. However, this technology is not quantitatively extruded according to the shape of the panel, and there is a problem that residues are generated. Therefore, an free-form panel extrusion experiment was conducted to analyze the limitations of existing nozzles and to analyze the requirements for the development of new concrete extrusion nozzles. Existing nozzles were unable to be quantitatively extruded, resulting in errors. Due to the weak pressure of the screw and the inability to adjust the internal pressure, detailed extrusion speed control was impossible, and residue generation in the opening and closing device seemed to be the cause. Therefore, a pump capable of quantitative concrete pressure transfer and a pressure control device for easy extrusion of concrete are required. In addition, it is judged that it is necessary to develop an opening and closing device and an extrusion device that do not generate residues. The results of this study are expected to provide information for FCP production and production and to be a basic study of technologies necessary for the production of free-form building panels.
김혜권 ( Kim Hye-kwon ),김지혜 ( Kim Ji-hye ),김성진 ( Kim Sungjin ),이동훈 ( Lee Donghoon ) 한국건축시공학회 2023 한국건축시공학회 학술발표대회 논문집 Vol.23 No.2
Free-form buildings have a curved shape and are composed of geometric shapes, which require high precision. Therefore, this study proposed a new extrusion method, a piston method, that improves the precision of FCP by automatically extruding a predetermined amount of concrete by improving the aforementioned limitations. The technology to extrude a predetermined amount of concrete by applying pistons is expected to shorten construction period and increase economic efficiency by improving the precision and productivity of free-form panels.
Comparison of the age-related porcine endogenous retrovirus (PERV) expression using duplex RT-PCR
문형준,김혜권,Seong Jun Park,Chul Seung Lee,Dae Sub Song,Bo Kyu Kang,박봉균 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.4
Porcine endogenous retroviruses (PERVs) are members of family Retroviridae, genus Gamma retrovirus, and transmitted by both horizontally and vertically like other endogenous retroviruses (ERVs). PERV was initially described in the 1970s having inserted its gene in the host genome of different pig breeds, and three classes, PERV-A, PERV-B, and PERV-C are known. The therapeutic use of living cells, tissues, and organs from animals called xenotransplantation might relieve the limited supply of allografts in the treatment of organ dysfunction. Because of ethical considerations, compatible organ sizes, and physiology, the pig has been regarded as an alternative source for xenotransplantation. Sensitive duplex reverse transcription-polymerase chain reaction protocols for simultaneously detecting PERV gag mRNA and porcine glyceraldehydes 3-phosphate dehydrogenase mRNA in one tube was established. To compare the age-related PERV expression patterns of the lung, liver, spleen, kidney, heart, and pancreas in commercial pigs, 20 pigs from four age groups (5 heads each in 10 days-, 40 days-, 70 days-, and 110 days-old, respectively) were used in this study. The expression patterns of PERV were statistically different among age groups in lung, liver, and kidney (ANOVA, p < 0.05). These data may support in the selection of appropriate donor pigs expressing low levels of PERV mRNA.