주류문화 1 - 막걸리 누보

김철훈,Kim, Cheol-Hun 한국주류산업협회 2009 주류산업 Vol.29 No.4

O/W 에멀젼의 입자크기 및 상거동에 미치는 다양한 전상유화법의 효과

김철훈,박재길,허정림,유영태,박태욱,이치규 ( Cheol Hun Kim,Jae Kiel Park,Jung Rim Haw,Young Tai Yoo,Tae Wook Park,Chi Giu Lee ) 한국공업화학회 1995 공업화학 Vol.6 No.4

유화제는 polyoxyethylene(20)sorbitan monostearate와 sorbitan sesquioleate를 혼합 사용하고, 오일상으로는 liquid paraffin을 원료로 사용하여 다양한 전상유화 법으로 O/W 에멀젼을 제조하였다. 전상유화공정중에 오일상에 첨가되는 적량의 물은 가용화 되거나 유화되어 W/O 에멀젼으로 된다. 이 W/O 에멀젼은 분산상의 부피변화나(catastrophic inversion) 유화제의 오일과 물에 대한 친화도변화(transitional inversion)에 의해 O/W 에멀젼으로 전환된다. Direct 유화방법을 채택한 2단계 전상유화법의 공정에서는 잠정적인 (W/O)/W 이중에멀젼이 형성되었다 : 최종에멀젼이 W/O→(W/O)/W→O/W의 전환 단계를 거쳐서 생성되었다. 이 전환에서는 catastrophic inversion이 일어났다. 1단계 및 3단계 전상유화법은 W/O에서 pseudomicroemulsion gel상을 거쳐서 미세하고 균일한 O/W에멀젼입자가 얻어졌다 : W/O→pseudomicroem ulsion gel상→O/W. 이 전환에서는 연속상의 일정농도(5∼17wt%) 내에서 transitional inversion이 일어남을 알 수 있었고, 3단계 전상유화법이 2단계 전상유화법보다 더 미세하고 균일한 입자를 갖는 높은 점도의 에멀젼을 생성하였다. 본 연구에서 가장 미세하고 안정한 에멀젼입자가 형성되는 혼합유화제의 HLB 영역은 10.0∼10.8이었으며, 아울러 이 영역에서 오일상에 첨가되어 가용화되는 물의 양 또한 가장 많게 나타났다. O/W emulsions were prepared with the various phase inversion emulsification methods. The emulsifiers used were the polyoxyethylene(20)sorbitan monostearate and sorbitan sesquioleate, and the oil used was a liquid paraffin(dispersed phase). A portion of aqueous phase added during the phase inversion emulsification process is solubilized or emulsified into the oil phase to form a W/O primary emulsion. This primary emulsion eventually inverts to form an O/W final emulsion either by changing the dispersed phase volume(a catastrophic inversion) or by changing the surfactant`s affinity for the oil and water phases(a transitional inversion). A short-lived double emulsions of (W/O)/W type were formed in the process of the two-step phase inversion which adopted the direct emulsification method : O/W final emulsion was formed as follows, i.e., W/O→(W/O)/W double emulsion→O/W emulsion. Catastropic inversion occured in the two-step phase inversion emulsification method. In one-step phase inversion emulsification and three-step phase inversion emulsification, fine and homogeneous O/W emulsions were formed as follows, i.e., W/O→pseudomicroemulsion gel phase→O/W. In this method the transitional inversion occurred within constant concentration(5-17wt. %) of contineous phase. The more fine, homogeneous and viscous emulsion was prepared with the three-step phase inversion emulsification method than that of emulsions prepared with the two-step phase inversion emulsification method. The finest and most stable droplets were formed in 10.0∼10.8 HLB region of mixed surfactants and this HLB region had maximum amount of solubilizing water.

당뇨 유도 백서 경골에 매식한 티타늄 임플란트 주위에 지방조직 유래 줄기세포 적용 시 골치유에 미치는 영향

김민구(Min-Gu Kim),정인교(In-Kyo Jung),신상훈(Sang-Hun Shin),김철훈(Chul-Hoon Kim),김복주(Bok-Joo Kim),김정한(Jung-Han Kim),황영섭(Young-Sup Hwang),정유진(Eu-Gene Jung),김진우(Jin-Woo Kim),김욱규(Uk-Kyu Kim) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.5

Introduction: Diabetes mellitus, as a major health problem for the elderly has been shown to alter the properties of the bone and impair bone healing around a titanium implant in both humans and animals. The aim of this study was to examine the effect of adipose-derived stem cells on the healing process around a titanium implant in streptozotocin-induced diabetic rats. Materials and Methods: Thirteen rats were divided into two groups: adipose-derived stem cells injected group and a control group. A titanium screw implant (diameter: 2.0 mm, length: 3.5 mm) was placed into both tibia of 13 rats: 13 right tibia as the control group and 13 left tibia as the experimental group. The rats were sacrificed at different intervals (1, 2, and 4 weeks) after implantation for histopathology observations and immunohistochemistric analysis. Results: The histopathological findings revealed earlier new formed bone in the experimental group than the control group. In particular, at 1 week after implantation, the experimental group showed more newly formed bone and collagen around the implant than the control group. In immunohistochemistric analysis, osteoprotegerin (OPG) expression in the experimental group increased early compared to that of the control group until 2 weeks after implantation. However, after 2 weeks, OPG expression in the experimental group was similar to OPG expression in the control group. The receptor activator of nuclear factor κB ligand (RANKL) expression in the experimental group increased early compared to that of the control group, and then decreased at 2 weeks. After 2 weeks, the level of RANKL expression was similar in both groups. Conclusion: These results suggest that adipose-derived stem cells in implantation can promote bone healing around titanium, particularly in diabetes mellitus induced animals.

A retrospective randomized study of success rates according to abutment selection in DENTIS submerged implant with an internal hex connection

Eun-Hee Kim(김은희),Joeng-Eun Lee(이정은),Hee-Seong Hwang(황희성),Chul-Hoon Kim(김철훈),Jung-Han Kim(김정한),Bok-Joo Kim(김복주) 대한치과의사협회 2018 대한치과의사협회지 Vol.56 No.11

PURPOSE. The purpose of this study is to determine the efficacy of the DENTIS submerged-type implant with an internal hex connection and to build corresponding abutment-selection criteria. MATERIAL AND METHODS. A total of 204 patients received submerged implant fixtures with an internal hex connection at the Dong-A University Hospital Dental clinic in Busan from January 2013 and May 2016. Three specific abutments, UCLA abutments, customized abutments, ready-made abutments, were randomly selected. Implant success was defined as the basis of the International Congress of Oral Implantologists(ICOI, 2007) criteria. The relationship between the implant success rate and the abutment factor was analyzed using the Kruskal-Wallis test(P<.05). RESULTS. A total of 508 implants were placed in 204 patients. After a mean observation period of 38.6 months, 493 out of 508 implants were in normal function, yielding an overall success rate of 97.05%. A total of 15 implants failed: 10 in the maxillary molar area, 4 in the mandibular molar area, and 1 in the mandibular incisal area. All of the implant failures occurred in a singleimplant prosthesis, especially high in the maxillary molar area. The Kruskal-Wallis analysis showed that abutment selection has no significant correlation with implant failure(P>.05). CONCLUSION. DENTIS submerged implants with an internal hex connection showed predictable results with a success rate of 97.05%. It is no influence on the success rate in the selection of submerged implant abutment with an internal hex connection.

Le Fort I 골절단술에서 posterior impaction의 양과 occlusal plane angle, incisor inclination의 변화 관계에 관한 연구

김복주(Bok-Joo Kim),김민구(Min-Gu Kim),김정한(Jung-Han Kim),김철훈(Chul-Hoon Kim) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.5

Introduction: In the management of dentofacial deformities, variable movement of the maxilla can be made possible by a Le Fort I osteotomy. Posterior impaction of the maxilla necessary for rotation of the maxillomandibular complex enhances the functions and esthetic results. In cases of posterior impaction of the maxilla, an increase in the figure of the occlusal plane angle and incisor inclination can occur. This study reports the relationship between the amount of posterior impaction and the change in the occlusal plane angle and incisor inclination in a Le Fort I osteotomy by preoperative and postoperative lateral cephalograms. Materials and Methods: Twenty patients who had undergone orthognathic surgery in Dong-A University Medical Center participated in this study. Lateral cephalometrics, within 3 weeks prior to surgery and 3 days after surgery, were used for analysis. Pre and postoperative measurements of the occlusal plane angle and incisal inclination based on the Frankfort horizontal (FH) plane were performed. X and Y were defined as the amount of vertical change in the upper incisor tip and the amount of vertical change in the upper first molar mesial cup tip through the operation. The amount of final posterior maxillary impaction was determined by subtracting Y from X, which is the difference in vertical height. According to the amount of posterior maxillary impaction, the change in the occlusal plane angle and incisal inclination was measured. Results: The average posterior maxillary impaction was 2.91 mm and the average change in the occlusal plane angle and incisal inclination was 6.54after surgery. As a result, each mm of posterior maxillary impaction changed the occlusal plane angle and incisal inclination by 2.25. Statistically, there was high significance. Two cases were observed: one with the same amount of posterior maxillary impaction performed on both the right and left showing 2.20, and the other with a different amount of posterior maxillary impaction performed showing 2.35. In this case, there was no significance difference between the two cases. Conclusion: Each mm of posterior maxillary impaction changes the occlusal plane angle and incisal inclination by an average of 2.25. In posterior maxillary impaction, there was no significant difference in the amount of change in the occlusal plane angle and incisal inclination regardless of whether there was an equal amount of posterior maxillary impaction on both sides. This study is expected to help in the presurgical orthodontic preparation and presurgical treatment planning.

서울지역의 개와 고양이에서 분리한 Staphylococcus aureus의 항생제 감수성 및 multiplex PCR을 이용한 장독소의 검출

김능희 ( Neung Hee Kim ),채희선 ( Hee Sun Chae ),손홍락 ( Hong Rak Son ),김창기 ( Chang Ki Kim ),김선흥 ( Sun Heung Kim ),이정학 ( Jung Hark Lee ),김철훈 ( Chul Hun Kim ) 한국가축위생학회 2010 韓國家畜衛生學會誌 Vol.33 No.3

The antimicrobial susceptibility of 73 strains of Staphylococcus aureus isolated from dogs and cats was determined against 16 antimicrobial agents. All isolates were susceptible to cephalothin (CF), vancomycin (VA), rifampin (RA), quinupristin-dalfopristin (SYN) and linezolid (LZD), whereas more than 86.3% of the isolates were resistant to penicillin (P). In the case of enterotoxin production, 8.2% of 73 strains produced enterotoxin A and 1 strain produced enterotoxin C. Appropriate protocols for antimicrobial agents and strategies to reduce antimicrobial resistance will need to be investigated in the future.

서울지역 길고양이의 Toxoplasma 감염증 실태조사

김능희 ( Neung Hee Kim ),채희선 ( Hee Sun Chae ),한혜진 ( Hye Jin Han ),손홍락 ( Hong Rak Son ),김창기 ( Chang Ki Kim ),김선흥 ( Sun Heung Kim ),이정학 ( Jung Hark Lee ),김철훈 ( Chul Hun Kim ) 한국가축위생학회 2009 韓國家畜衛生學會誌 Vol.32 No.3

Toxoplasma gondii is one of the most common protozoa parasites of human and other warm-blooded animals. Cats and wild felidae play crucial roles in the epidemiology of toxoplasmosis. This study was performed to survey the prevalence of T. gondii infection among stray cats in the Seoul. A total of 422 stray cat blood samples were collected from Seoul area. Positive sera for T. gondii were identified in 56 samples (13.3%) exclusively via the latex agglutination test and the detection no antigen particles among seropositive samples by PCR. The overall infection rate of male stray cats (14.4%) presented as higher than that of female cats (10.7%). This study suggested that T. gondii is widespread in stray cats of Seoul area. It is needed to control urban stray cat population and to reduced the risk of zoonotic transmission of toxolasmosis to other animals and humans.

이하선 천엽에 발생한 지방종의 치험례

김정한(Jung-Han Kim),김철훈(Chul-Hoon Kim),김민구(Min-Gu Kim),송진우(Jin-Woo Song),정유진(Eu-Gene Jung),김복주(Bok-Joo Kim) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.5

A lipoma is a benign tumor of matured adipose tissue that usually occurs at the shoulder, back, and abdomen. 13% of lipomas occur in the head and neck area. However, the incidence of lipoma in the parotid gland is very low, approximately 2.5%. A conservational surgical excision is recommended in cases of lipoma of the parotid gland, with only 1-2% of lipomas recurring. We report a case of a lipoma in the parotid gland that was removed by conservational surgical excision. The lesion was exposed by the pre-auricular approach and the tissue was detached. After the parotid gland envelop was exposed, a yellowish mass is observed that was easy to remove due to capsulation. Most authors recommend a surgical excision of the superficial lobe of the parotid gland as the treatment for a lipoma in the parotid gland. However, enucleation only may be a sufficient treatment when a lipoma occurs in the superficial lobe or around the parotid gland. A patidectomy is not needed when a lipoma is located at the superficial lobe of the parotid gland, and a conservational surgical excision is suitable. Therefore, a clinical diagnosis is important for reducing the damage to the facial nerve.

일 지역 여성의 결혼 전 건강검진에 대한 인지, 의도 및 이행정도

김철훈(Kim, Chul-Hoon),신유정(Shin, You-Joung),김명수(Kim, Myoung-Soo) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.7

본 연구의 목적은 일 지역 여성의 결혼 전 건강검진에 대한 인지, 의도, 이행정도를 파악하고, 미혼여성의 검진의도 및 기혼여성의 검진이행을 예측하는 요인을 규명하기 위한 연구로 총 257명의 연구대상자를 대상으로 하였 다. 자료는 결혼 전 건강검진에 대한 인지(인식, 태도, 주관적 규범, 행동통제인식), 의도, 이행정도를 묻는 질문지를 이용하여 조사하였고, 분석은 SPSSWIN 12.0 프로그램을 활용하여 평균, 표준편차, χ²-test, t-test, 다중회귀분석 (multiple Logistic regression)을 이용하였다. 결혼 전 건강검진을 수행한 정도를 살펴본 결과 28.4%의 기혼여성이 수 행한 것으로 나타났고, 35%의 미혼여성과 71.6%의 기혼 여성이 결혼전 건강검진에 대해 들어본 적이 있는 것으로 나타났다. 결혼 전 건강검진에 대한 태도는 미혼과 기혼여성에게서 각각 23.04점, 22.55점(t=1.39, p=.16), 주관적 규범 은 각각 14.49점과 14.46점 (t=.13, p=.90)으로 미혼여성이 기혼여성에 비해 긍정적이었으나 통계적으로 유의한 차이가 없었다. 하지만, 행동통제인식에서는 미혼여성이 15.46점, 기혼여성이 16.79점(t=5.32, p<.001)로 두 군간 유의한 차이 가 있었다. 미혼여성의 검진의도에 영향을 미치는 요인은 검진의 필요성(OR=14.186, t=.001)이었고, 기혼여성의 검진 이행에 영향을 미치는 요인은 검진에 대해 들은 경험(OR=7.765, p=.012)과 행동통제인식(OR=1.423, p=.025)이었다. 이 결과는 여성의 결혼 전 건강검진의 의도 및 실천을 증진시키기 위해서는 검진의 필요성에 대한 인지강화, 행동통제인 식의 강화가 필요하며 이를 위한 프로그램의 개발이 지역사회를 중심으로 이루어져야 함을 제시해준다. The objectives of this study were to identify recognition, intention and practice to premarital examination of women and to define the predictors of intention and compliance to examination. The subjects for this study were 257 women at a university, college, a bank worker and health clinic visitor in Busan city. The date for this study was collected from August 25th to September 24th 2006 by structured questionaries, and were analyzed mean, standard deviations(SD), χ²-test, t-test and multiple Logistic regression using SPSS/WIN 12.0. The mean performance of the premarital examination was 28.4%. Thirty-five point five percent of unmarried women and 71.6 percent of married women had experience of heard premarital examination. The score of attitude toward premarital examination were that single women was 23.04 and married women was 22.55, respectively. The scores of behavioral control cognition between unmarried women and married women were statistically significant different. The predictor of premarital examination intention was necessity of premarital examination, and the predictors of examination compliance were experience of hearing examination and behavioral control cognition. Based on the results of this study, promoting recognition and behavioral control cognition by community healthcare organization and health professionals for empowering the premarital examination of women were needed.

측두하악장애환자에서 악관절 세척술후 관절활액의 전구염증성 Cytokines의 발현

김철훈(Cheol-Hun Kim),황희성(Hie-Sung Hwang),신상훈(Sang-Hoon Shin),정인교(In-Kyo Chung),황태호(Tae-Ho Hwang) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.5

The purpose of this study is that evaluate the distribution and biological roles of TNF-a, interleukin-1β(IL-1β), interleukin-6(IL-6) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the synovial fliud of patients with non-inflammatory chronic temporomandibular joint(TMJ) disorders in relation to pain during joint movements and magnetic resonance imaging(MRI) findings. TMJ synovial fluids aspirates were obtained from 36 patients (36 joints) with chronic TMJ disorders and from 8 controls(8 joints). Patients were divided to four groups. The control group was from healthy volunteers(8 joints), group I(18 joints) was patients with anterior disc displacement with reduction, group II(5 joints) was patients with disc displacement without reduction and group III (5 joints) was osteoarthritis. The TNF-α, IL-1βand IL-6 levels in the aspirates were determined by using an enzyme-linked immunosorbent assay and the TIMP-1 level was measured by an enzyme immunoassay. Following examinations for pain during joint movements and MRI observations, these cytokines’level and frequencies of detection were compared. The level of IL-1βwas not significant different in all groups. but the level of TNF-α, IL-6 and TIMP-1 were significant different among groups. The level of IL-6 and TIMP-1 were correlated to pain during movement(p〈0.01) and the level of TNF-a(p〈0.05). Also, the level of IL-6 was correlated to the level of TIMP-1(p〈0.01). Especially, The level of the TIMP-1 level was significantly correlated to the pain during movement and showed very high levle of Pearson’s correlation coefficient (r=0.833)(p〈0.001). The results indicated that the TNF-α, IL-6 and TIMP-1 levels in the TMJ aspirates of patients with chronic TMJ disorders have been raised. Especially, IL-6 and TIMP-1 were very high levels in the patients who were degraded in the TMJ. Also, TNF-α, IL-6 and TIMP-1 showed the significant correlation in the chronic temporomandibular joint disorders. Therefore I suggest that these cytokines were also correlated to the pain during movement in the chronic temporomandibular joint disorders