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돼지 관상동맥 스텐트 재협착에 대한 Endothelin 수용체 차단제 국소 전달요법의 효과
김진우(Jin Woo Kim),강정채(Jung Chaee Kang),박창수(Chang Soo Park),김완(Wan Kim),정명호(Myung Ho Jeong),김용록(Yong Rok Kim),조장현(Jang Hyun Cho),김주한(Ju Han Kim),김성희(Sung Hee Kim),배열,안영근(Young Keun Ahn),박주형(Joo Hyung Pa 대한내과학회 1999 대한내과학회지 Vol.56 No.6
Objectives : Coronary stent is one of the most effective currently available devices in the treatment of coronary artery diseases. But, coronary stent restenosis is one of major limitations in clinical stenting. Local drug delivery may be a new strategy for the prevention of stent restenosis. Endothelin receptor blocker is known to have vasodilatory and antiproliferative activities. To investigate the effects of local endothelin receptor blocker delivery on stent restenosis, local delivery was performed in the porcine model of coronary stent restenosis. Methods : Stent overdilation injury alone was performed in the control porcine coronary arteries (n=4, group A) and local delivery of endothelin receptor blocker prior to stenting was performed in the porcine coronary artery (n=9, group B). Endothelin receptor blocker (TAK-044, Takeda, Japan) was delivered at a rate of 1 ml/min (50 mg/10 ml) using the Dispatch Catheter. Follow-up quantitative coronary angiogram (QCA) and immunohistopathologic assessment were performed 4 weeks after stenting. Results : 1) On QCA, percent diameter stenosis was significantly higher in Group A than in Group B (29.4±6.1 % vs. 14.5±11.6%, p<0.05). 2) Area stenosis was higher in Group A than in Group B (63.5±23.2 % vs. 40.9±13.3 %) measured by histopathologic method (p<0.05). 3) Neointimal area was higher in Group A than in Group B (3.53±1.9 mm2 vs. 1.75±0.8 mm2, p=0.03). 4) By immunocytochemistry, proliferating cell nuclear antigen index was higher in Group A compared with Group B (46.8±5.2 % vs. 31.1±3.7 %, p<0.05). Conclusion : Local delivery of endothelin receptor blocker is effective in the prevention of stent restenosis in a porcine model, which may be related with the partial inhibition of cell proliferation of neointimal cells.
산화니켈-${\alpha}$ 형 산화철 상에서 이산화황의 산화 반응메카니즘
이규용,김용록,이성한,Kyu Yong Lee,Yong Rok Kim,Sung Han Lee 대한화학회 1983 대한화학회지 Vol.27 No.3
이산화황의 산화반응을 10 mol % $Ni-doped\;{\alpha}-Fe_2O_3$를 촉매로 하여 반응온도 범위 $320{\sim}440{\circ}C$에서 여러 산소 및 이산화황의 부분압으로서 반응속도를 측정하였다. 위 온도 영역에서 $SO_2$ 산화반응의 활성화에너지 값은 13.8 $kcal{\cdot}mol^{-1}$로서 얻어졌다. 반응속도 데이타는 산소에 대해서 0.5차, 이산화황에 대해서는 1차로서 전반응차수는 1.5차를 나타내었다. 이산화황과 산소를 여러 압력으로서 도입하여 전기전도도를 측정하였다. 반응속도 데이타와 전기전도도 데이타로 부터 반응기체들의 산화물계상에서 흡착메카니즘을 제안하였고, 촉매상에서 $SO_2$의 산화반응 메카니즘을 제안하였다. 산소와 이산화황은 이온상태로서 흡착하며, 산소는 니켈 dope로 인해 형성된 산소공위에 이산화황은 격자 산소에 흡착하였다. 반응속도 데이타와 전기전도도 데이타로부터 이산화황의 산화반응속도를 결정짓는 단계는 이산화황이 격자산소에 흡착하는 과정임을 알았다. The catalytic oxidation of $SO_2$ has been investigated in the presence of vacuum-activated 10 mol % Ni-doped ${\alpha}-Fe_2O_3$ under various partial pressures of $SO_2\;and\;O_2$ at temperatures from 320 to $440{\circ}C$. Over the temperature range $320{\sim}440{\circ}C$, the activation energy is 13.8 $kcal{\cdot}mol^{-1}$. The oxidation rates have been correlated with 1.5 order kinetics; first order with respect to $SO_2$ and 0.5 order with respect to $O_2$. From the kinetic data and conductivity measurements, the adsorption, oxidation mechanism of $SO_2$ and the defect structure of vacuum-activated 10 mol % Ni-doped {\alpha}-Fe_2O_3$ are suggested. $O_2\;and\;SO_2$ appear to be adsorbed essentially as ionic species. Two surface sites, probably an $O^{2-}$ lattice and an oxygen vacancy which is induced by Ni-doping, might be required to adsorb $SO_2\;and\;O_2$. The conductivity measurements and kinetic data indicate that the adsorption process of $SO_2\;{(SO_2+O^{2-}}_{(latt)}{\rightleftharpoons}{{SO_3}^-}_{(ads)}+e')$ is the rate-determining step.
CdO-${\alpha}-Fe_2O_3$촉매상에서 일산화탄소의 산화반응에 대한 CdO의 첨가 효과
이성한,김용록,김규홍,최재시,Sung Han Lee,Yong Rok Kim,Keu Hong Kim,Jae Shi Choi 대한화학회 1985 대한화학회지 Vol.29 No.2
4 mol% Cd-doped ${\alpha}-Fe_2O_3$, 8 mol% Cd-doped ${\alpha}-Fe_2O_3$ 및 12 mol% Cd-doped ${\alpha}-Fe_2O_3$상에서 CO 산화반응이 각기 연구되었다. Cd의 doping level에 관계없이 반응차수는 1.5차이며 CO에 대하여 1차, $O_2$에 대하여 O.5차이다. 350∼$460^{\circ}C$의 반응온도 범위에서 CO산화반응의 활성화 에너지는 10.10∼11.30Kcal/$mol^{-1}$ 이며 Cd-doped${\alpha}-Fe_2O_3$의 전기전도도 데이타와 반응속도 데이타로부터 CO산화반응 메카니즘이 규명되었다. 특히 Cd doping 효과로부터 ${\alpha}-Fe_2O_3$의 촉매활성이 격자산소의 공위에 포획되어 있는 전자의 여기(excitation)에 기인된다는 사실이 밝혀졌으며 반응분자들의 흡착자리를 알게 되었다. The oxidation reaction of CO on the catalysts 4 mol%, 8 mol%, and 12 mol% Cd-doped ${\alpha}-Fe_2O_3$ is individually investigated. Regardless of Cd doping level, over-all reaction order for the oxidation of CO is 1.5; the first order with respect to CO and the one-half order with respect to $O_2$. Over the temperature range of 350∼$460^{\circ}C$, the activation energy for CO oxidation is 10.10∼11.30Kcal/mol. From the agreement between the kinetic data and conductivity measurements, the reaction mechanism is suggested. Especially from the effect of Cd doping, the fact that catalytic activity of ${\alpha}-Fe_2O_3$ is due to the excitation of electrons which are traped on oxygen vacancy is found, and the adsorption sites for reactant molecules are found.
김완(Wan Kim),김용록(Yong Rok Kim),염형렬(Houng Roul Youm),백종철(Jong Cheol Baek),이형우(Hyoung Woo Lee),고향미(Hyang Mee Ko),강헌석(Heon Seok Kang),임종철(Jong Cheol Lim),류형선(Heong Seon Rheu),명재일(Jae Il Myung) 대한내과학회 1999 대한내과학회지 Vol.56 No.6
Cutaneous metastases from gastric carcinoma are uncommon. The frequency of metastses to the skin from gastric carcinoma have ranged from 0.3% to 0.4%. Carcinoma en cuirasse, first described by Velpeau in 1838, is marked sclerodermatous change and characterized by a difffuse morphea-like induration of the skin and represents a rare manifestations of breast carcinoma metastatic to the chest wall. It is vary rarely seen in lung, stomach, kidney and other metastasizing malignancies. We report a case of carcinoma en cuirase and nodular carcinoma from gastric carcinoma in a 36-year-old male who complained chiefly of multiple cutaneous nodules. He had mixed lesions of an erythematous morphea-like induration on the neck and multiple erythematous nodules on the chest and abdomen. Gastroscopy finding showed a Borrmann type Ⅳ advanced gastric carcinoma. Histopathologic examination of skin and stomach showed atypical cells with pleomorpic, hyperchromatic nuclei and scanty, eosinophilic cytoplasm, which are consistent with poorly differentiated adenocarcinoma. Immunohistochemical stainings showed positive reaction for cytokeratin. He died three months after the appearance of cutaneous lesions.