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까마귀쪽나무(Litsea japonica)의 HL-60 백혈병 세포 Apoptosis 유도효과
김엘비라,부혜진,현재희,김상철,강정일,김민경,유은숙,강희경,Kim, Elvira,Boo, Hye-Jin,Hyun, Jae-Hee,Kim, Sang-Cheol,Kang, Jung-Il,Kim, Min-Kyoung,Yoo, Eun-Sook,Kang, Hee-Kyoung 대한약학회 2009 약학회지 Vol.53 No.1
This study investigated the antiproliferative effect of the EtOH extract from Litsea japonica. The extract markedly inhibited the growth of HL-60 cells. When treated with the extract, several apoptosis events like as DNA fragmentation, chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. The extract decreased the Bcl-2 expression, whereas the Bax expression was increased. Caspase-9 and -3 were activated and poly (ADP-ribose) polymerase was cleaved. The results suggest that the antiproliferative effect of L. japonica in HL-60 appears to arise from apoptosis induction via the down-regulation of Bcl-2 and the activation of caspases.
까마귀쪽나무(Litsea japonica)의 HL-60/ADR 세포 Apoptosis 유도효과
김엘비라,현재희,김상철,강정일,김민경,유은숙,부혜진,강희경 한국생약학회 2009 생약학회지 Vol.40 No.1
The present study investigated the antiproliferative effect of Litsea japonica in HL-60/ADR, adriamycin resistant human promyelocytic leukemia cells. The 80 % ethanol extract of L. japonica markedly inhibited the growth of HL-60/ADR cells. When HL-60/ADR cells were treated with the extract, several apoptosis events like as DNA fragmentation, chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. In the mechanism of apoptosis induction by L. japonica, we examined the changes of Bcl-2 and Bax protein expression levels, and activation of caspases. After the HL-60/ADR cells were treated with the extract, the Bcl-2 expression was decreased, whereas the expression of Bax was increased in a time-dependent manner compared to the control. In addition, the active forms of caspase-9 and -3 were increased and the cleavage of poly (ADP-ribose) polymerase, a vital substrate of effector caspase, was observed. The results suggest that the inhibitory effect of L. japonica on the growth of the HL-60/ADR appears to arise from the induction of apoptosis via the down-regulation of Bcl-2 and the activation of caspases.
문주란 추출물의 HL-60 백혈병 세포 Apoptosis 유도 효과
현재희,김엘비라,강정일,김상철,유은숙,강희경,Hyun, Jae-Hee,Kim, El-Vi-Ra,Kang, Jung-Il,Kim, Sang-Cheol,Yoo, Eun-Sook,Kang, Hee-Kyoung 대한약학회 2008 약학회지 Vol.52 No.1
The present study investigated the antiproliferative effects of Crnum asiaticum var. japonicum against HL-60 human leukemia cells. The 80% MeOH extract or several solvent fractions from the C. asiaticum inhibited the growth of HL-60 cells, whereas the growth of HEL-299 cells, human embryonic lung fibroblast, was scarcely inhibited. When the HL-60 cells were treated with the $CHCl_3$ fraction, the BuOH fraction, the EtOAc fraction and the $H_2O$ fraction, DNA ladder, chromatin condensation and increase of sub-G1 hypodiploid cells were observed. Furthermore, the $CHCl_3$ fraction and the BuOH fraction reduced Bc1-2 mRNA level, whereas Bax mRNA level was increased. These results suggest that the inhibitory effect of C. asiaticum on the growth of the HL-60 cell might be mediated through the induction of apoptosis via the down-regulation of Bc1-2. Taken together, components of C. asiaticum might have a therapeutic potential for the treatment of human leukemia.