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튜머로이드-혈관신생 상호작용의 가시화를 위한 개방형 구조 미세유체 칩 개발
김승규(Seunggyu Kim),김지원(Jiwon Kim),박준하(Joonha Park),오상윤(Sangyoon Oh),신현정(Jennifer H. Shin),전성윤(Jessie S. Jeon) 한국가시화정보학회 2020 한국가시화정보학회지 Vol.18 No.3
Cancer cells secrete angiogenic factors, and nearby vasculatures make new blood vessels essential for cancer development and metastasis in response to these soluble factors. Many efforts have been made to elucidate cancer-endothelial cell interactions in vitro. However, not much is known due to the lack of a suitable co-culture platform. Here, we introduce a 3D printing-based microfluidic system that mimics the in vivo-like cancer-endothelial cell interactions. The tumoroids and endothelial cells are co-cultured, physically separated by porous fibrin gel, allowing communication between two cell types through soluble factors. Using this microfluidic system, we were able to visualize new vessel formation induced by tumoroids of different origins, including liver, breast, and ovary. We confirmed that the ovarian tumoroids most induced angiogenesis while the other two cancer types suppressed it. Utilization of the proposed co-culture platform will help the researchers unveil the underlying mechanisms of the dynamic interplay between tumor and angiogenesis.
클러치 드럼허브 프리폼의 딥드로잉 공정에서 금형의 소재도입부 형상이 두께 분포에 미치는 영향
김승규(S. G. Kim),박준홍(J. H. Park),서성열(S. Y. Seo),박건형(G. H. Park),강정호(J. H. Kang),박영철(Y. C. Park) 한국기계가공학회 2008 한국기계가공학회 춘추계학술대회 논문집 Vol.2008 No.-
Deep Drawing Process is used often in Forming Clutch Drum hub Preform. Optimizing die design and the process variables such as die shoulder shape influences Thickness Variation of Drum-hub preform. Using FE-simulation, examine their relation. To find the optimum conditions for improving deep drawing, a series of the experiments are preformed. From the results of this propose die shoulder shape and optimum measure. And the optimum values of process variables are examined and discussed.