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한국인 사회공포증 환자에서 도파민 D2 수용체 TaqI A 유전자 다형성 : 예비적 연구
김범조,임세원,신동원,오강섭,이민수,Kim, Bum-Jo,Lim, Se-Won,Shin, Dong-Won,Oh, Kang-Seob,Lee, Min-Soo 대한생물정신의학회 2007 생물정신의학 Vol.14 No.2
Objective : It is suggested that disturbance of dopaminergic system might be related to the possible mechanism of social phobia. The aim of this study was to investigate the possible association of DRD2 TaqI polymorphism and social phobia. Method : Fifty-one patients with social phobia and 200 comparison subjects were tested for DRD2 TaqI A polymorphism. The severity of social phobic symptoms was measured by self-report version of the Liebowitz Social Anxiety Scale(LSAS-SR) and Hamilton anxiety scale(HAM-A). Results : There was no signigicant difference in the genotype, allele frequency, A1 carrier frequency, and heterozygote frequency DRD2 TaqI A polymorphism between the social phobia patients and the control groups. However, we found significant decrease in somatic anxiety of the HAM-A in the patients having A2A2 homozygotes(p=0.014). In addition, patients having A1A2 heterozygotes showed more anxiety in two subscales (p=0.042 in anxiety, p=0.019 in performance) of the LSAS-SR. Conclusion : These results suggest that DRD2 A2 homozygote might have a protective role against somatic anxiety, and molecular heterosis of DRD2 TaqI A polymorphism might be related with more severe anxiety in social phobia.
공황장애와 도파민 D2 수용체 TaqI A 다형성의 관련
임세원,김범조,오강섭,이민수,Lim, Se-Won,Kim, Bum-Jo,Oh, Kang-Seob,Lee, Min-Soo 대한불안의학회 2006 대한불안의학회지 Vol.2 No.1
Puropse : Disturbances of dopaminergic system might be related to the possible mechanism of panic disorder. This study was aimed to examine the association of DRD2 Taq 1 polymorphism and panic disorder. Methods : One hundred and fourteen patients with panic disorder (62 male (54.4%), mean age $40.96{\pm}0.11$ years) and 200 comparison subjects (114 male (57.0%), mean age $35.57{\pm}8.81$ years)were tested for DRD2 TaqI A polymorphism. We excluded panic patients with comorbid alcohol related disorders, bipolar disorders, and any kinds of psychotic disorders because there have been some reports about association of these disease and DRD2 TaqI A polymorphism. Results : There was significant difference in the frequency of the genotype in DRD2 polymorphism between patients and controls (${\chi}^2$=6.09, df=2, p=0.048). The A1+ allele (A1A1 and A1A2) frequency analysis also showed significant association (${\chi}^2$=4.08, df=1, p=0.043). In addition, we observed a more strong and specific association between panic disorder and the A1+ allele of the DRD2 TaqI polymorphism for men (${\chi}^2$=4.71, df=1, p=0.03), but not for women (${\chi}^2$=0.45, df=1, p=0.50). Conclusion : These results in our Korean sample suggest that the DRD2 TaqI A polymorphism may be associated with panic disorder. Furthermore, we found sex-specific association of DRD2 A1 allele with panic disorder.
안영균(Young Kyun Ahn),신영철(Young Chul Shin),고복자(Bok Ja Koh),심진현(Jin Hyun Shim),김범조(Bum Jo Kim),이승민(Seung Min Lee),이길홍(Kil Hong Lee) 한국중독정신의학회 2005 중독정신의학 Vol.9 No.1
This study was conducted to investigate the differences in psychopathology and coping strategies among internet addictors, over users and non addictors in high school students. Subjects were 273 high school students in Seoul city. Self rating questionnaires included demographic data, Young’s Internet Addiction Scale, SCL-90-R, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory, and The Way of Coping Strategy. Subjects were classified into 3 groups (addiction, over use, non addiction) by Internet Addiction Scale score. Prevalence of internet addiction was 4.3% and male adolescents were more addictive than female. Students who were mainly involved with internet chatting or game showed higher internet addiction score. The addiction group and over use group showed higher level of somatization, obsession, interpersonal sensitivity, depression, anxiety, hostility, and paranoia than non-addicted group. Addiction group and over use group used passive coping strategies more frequently in the stressful situation than nonaddicted group. Also, the regression analysis for finding out causal factors that predicts internet addiction showed that emotion relieving strategy were important variable which predict internet addiction. Interpersonal sensitivity and emotion relieving coping strategy was important to predict addiction. This study showed that problematic internet use was closely associated with psychopathology and psychiatric comorbidity. And high interpersonal sensitivity and emotion relieving coping strategy were related with internet addiction in adolescence.
도시 쉼터 남성 노숙자에서 병적 도박의 실태와 심리사회적 특성
최삼욱(Sam-Wook Choi),신영철(Young-Chul Shin),신은정(Eun-Jung Shin),김현수(Hyun-Soo Kim),이재헌(Jae-Hun Lee),김범조(Bum-Jo Kim) 한국중독정신의학회 2007 중독정신의학 Vol.11 No.1
Objectives:This study was to assess the prevalence of pathological gambling in homeless men living in a city shelter in Seoul and to investigate the comparative characteristics of home-less people with and without probable pathological gambling. Methods:The subjects were 119 homeless men living in a city shelter in Seoul. Questionnaires on socio-demographic and psychiatric data were administrated to the subjects. Probable pathological gambling was assessed with Korean South Oaks Gambling Screen (K-SOGS) and probable alcohol dependence was evaluated by CAGE questionnaire. Results:The rate of lifetime probable pathological gambling was 34.5% (41 of 119) and the rate of probable alcohol dependence was 37.8% (45 of 119). The homeless in this study with probable pathological gambling were significantly more likely to have longer times of homelessness, more counseling experiences about gambling, more suicide at-tempts related to gambling problem, more gambling problems with parents, more frequent drinking per given week and higher CAGE scores than the homeless without probable pathological gambling. Conclusion:These results should encourage clinicians working with homeless people to screen for pathological gambling and alcohol use disorder as well. And the plans to approach and treat homeless people with addiction disorder should be made.