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ICR 신생마우스에서 N-2-Fluorenylacetamide의 발암현상
김무철,강상균 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.4
This experiment was carried out to evaluate the tumor incidence in ICR newborn mice using N-2- fluorenylacetamide (FAA). FAA in 1% aquous gelatin was injected subcutaneously on the subscapular region of ICR newborn mice once daily during the first five days of life. Gross examination of viscerae was performed immediately after being sacrificed at 68th week of birth. Following results were obtained. 1. The weaning rates of 1% aquous gelatin control group and FAA-treated group were 97.5% and 83.6%, respectively. In refer to gelatin control group, weaning rate of FAA-treated group was decreased by 9%. 2. Survival rate at 68th week showed 55% in normal control group and 52% in gelatin-treated group, while in FAA-treated group showed 69%. 3. The statistical analysis of body weight of FAA-treated animal does not show significant deviation from the non-treated controls. However, FAA-treated male mice showed a slight increment in weight at 34th week of birth as a result of enhanced development of hepatoma and lung adenoma. 4. There were no significant difference of organ weight between control and FAA-treated groups except liver and lung, Increased weighs of liver and lung was seen in FAA-treated group due to development of hepatoma and adenoma. 5. Pulmonary adenoma and hepatoma were seen in FAA-treated mice at 68th week of birth. The incidence of pulmonary adenoma was 1% in normal and 11% in gelatin-treated groups, while FAA-treated group showed 18%. No hepatoma development was identified in normal, gelatin-treated group and in female mice 'th FAA-treated group. On the other hand, hepatoma developed in male FAA-treated mice with wi incidence of 64%.
김무철(Mucheol Kim) 한국전자거래학회 2016 한국전자거래학회지 Vol.21 No.1
웹의 발달과 함께 많은 정보들이 쏟아지기 시작했다. 그에 따라서 사회 이슈들을 소셜 데이터로부터 추출하고, 이에 대한 해결 방법을 모색하는 연구에 대한 관심이 많아지고 있다. 이에 본 연구에서는 과학기술문헌들을 수집하고, 분석해서 이슈 토픽 별로 군집화 하는 연구를 수행한다. 이를 위해서 보건분야의 주요 용어들을 중심으로 수집하고, 효과적인 분석을 위한 데이터 처리 및 토픽들을 중심으로 군집화 연구를 수행한다. 그 결과, 연구 이슈들을 도출하고 사회 현상에 대한 해결 방안을 마련할 수 있는 토대를 구축하고자 한다. With the development of web, amount of information are generated in social web. Then many researchers are focused on the extracting and analyzing social issues from various social data. The proposed approach performed gathering the science data and analyzing with LDA algorithm. It generated the clusters which represent the social topics related to ‘health’. As a result, we could deduce the relationship between science data and social issues.
Levamisole에 의한 Ehrlich 腹水癌 生存率 延長에 關하여
康相均,金武哲 중앙대학교 의과대학 의과학연구소 1979 中央醫大誌 Vol.4 No.1
Since B.C.G. was introduced into immune therapy of cancer several biologic as well as chemical immune therapy was established. The mechanisms of anticancerous effect by these agents were still unproved, however, many authors believe that immune system stimulation plays major role. Levamisole is one of antiparasitic drug which showed anticancerous effect in experimental animal by way of immune stimulation. Ehrlich ascites tumor was implanted into the mouse peritoneal cavity, then Levamisole effect was observed in this experiment. Levamisole was administered intraperitoneally and subcutaneouslly to the experimental animals. Single, three, four and seven times of doses were given to each animal group respectively. Survival day to experimental animal is compared with control group, and survival rate was observed. Obtained results were follows; 1. Mean survival days of control group was 10.8 days, while Levamisole administered prolongation. Increment of survival rate was range of 31.5-42.6% in the experimental groups. 2. The most prolonged survival days were seen in intraperitoneal single doses of Levamisole administered group. 3. The difference of dose or method of Levamisole administration showed no significant difference of survival day and rate of the experimental animal groups. The above results suggest anticancerous effect of Levamisole upon the Ehrlich ascites tumor cells by chemical stimulation.
대학 전산망에서의 외부 침입에 적합한 대응을 위한 보안관제 기술 연구
강병관,김무철 한국산업보안연구학회 2014 한국산업보안연구 Vol.4 No.1
정보의 양이 급격히 증가함에 따라 정보에 대한 관리 및 보안 취약점들이 다 양하게 존재하게 되었다. 뿐만 아니라 대학의 경우 다수의 IT자원에 대비하여 관 리 인력이 부족함에 따라서 외부의 위협에 대처할 수 있는 방안이 부족한 실정 이다. 따라서 본 연구에서는 보안 에이전트 도입을 통해서 소수의 보안 담당자 만으로도 효과적으로 보안 관제를 수행할 수 있는 환경을 마련한다. 또, 좀비 PC의 발생에 대처하기 위한 좀비PC탐지 기법과 외부 침입 탐지 및 방지 기술을 조합하여 대학 환경에 적합한 보안관제 방안을 제시한다. 주제어: 보안관제, With the rapid increase of information, the security vulnerability are emerging issue in information management. In addition, coverage of security monitoring services in university is so large, but they have the problem of the lack of administrative staff. This paper suggests the appropriate solutions against external cyber-attacks. They are anti-virus solutions, detections of zombie PC and the intruder detections and preventions.